YAP drives cell competition by activating choline metabolism.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.07.101
Abstract: Cell competition is a phenomenon that eliminates unfit cells from cell society, a function vital for maintaining cellular and organismal homeostasis. We previously showed that Madin-Darby canine kidney (MDCK) epithelial cells expressing the active form… read more here.
Keywords: yap dependent; cell competition; competition; choline metabolism ... See more keywords
B Cell Competition for Restricted T Cell Help Suppresses Rare-Epitope Responses
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.09.029
Abstract: SUMMARY The immune system responds preferentially to particular antigenic-epitopes contained within complex immunogens, such as proteins or microbes. This poorly understood phenomenon, termed ‘‘immunodominance,’’ remains an obstacle to achieving polyvalent immune responses against multiple anti-genic-epitopes… read more here.
Keywords: protein; competition; restricted cell; competition restricted ... See more keywords
Cell Competition, the Kinetics of Thymopoiesis, and Thymus Cellularity Are Regulated by Double-Negative 2 to 3 Early Thymocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107910
Abstract: Cell competition in the thymus is a homeostatic process that drives turnover. If the process is impaired, thymopoiesis can be autonomously maintained for several weeks, but this causes leukemia. We aimed to understand the effect… read more here.
Keywords: cell competition; cell; kinetics thymopoiesis; double negative ... See more keywords
Engineering cell fitness: lessons for regenerative medicine.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2017.05.005
Abstract: Cell competition results in the loss of weaker cells and the dominance of stronger cells. So-called 'loser' cells are either removed by active elimination or by limiting their access to survival factors. Recently, competition has… read more here.
Keywords: medicine; fitness; cell competition; cell ... See more keywords
Ribosomal Protein S12e Has a Distinct Function in Cell Competition.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.12.007
Abstract: Wild-type Drosophila cells can remove cells heterozygous for ribosomal protein mutations (known as "Minute" mutant cells) from genetic mosaics, a process termed cell competition. The ribosomal protein S12 was unusual because cells heterozygous for rpS12… read more here.
Keywords: cell competition; competition; wild type; ribosomal protein ... See more keywords
Cell Competition Triggers Suicide by Autophagy.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.09.014
Abstract: Cell competition eradicates weaker cells from an epithelium and is important for organ homeostasis. In this issue of Developmental Cell, Nagata et al. (2019) uncover that eradication of loser cells depends on autophagy-mediated cell death. read more here.
Keywords: suicide autophagy; triggers suicide; competition triggers; cell competition ... See more keywords
Systemic Regulation of Local Cell Competition.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.04.020
Abstract: Somatic scribble mutant cells are selectively eliminated from the growing Drosophila tissue through cell competition, a tumor-suppressing mechanism that ensures tissue integrity. In this issue of Developmental Cell, Sanaki et al. demonstrate that organismal hyperinsulinemia promotes… read more here.
Keywords: regulation local; systemic regulation; cell competition; cell ... See more keywords
ZAK Inhibitor PLX4720 Promotes Extrusion of Transformed Cells via Cell Competition
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101327
Abstract: Summary Previous studies have revealed that, at the initial step of carcinogenesis, transformed cells are often eliminated from epithelia via cell competition with the surrounding normal cells. In this study, we performed cell competition-based high-throughput… read more here.
Keywords: transformed cells; via cell; cell competition; plx4720 ... See more keywords
Exploring MYC relevance to cancer biology from the perspective of cell competition.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2019.05.009
Abstract: Cancer has long been regarded and treated as a foreign body appearing by mistake inside a living organism. However, now we know that cancer cells communicate with neighbours, thereby creating modified environments able to support… read more here.
Keywords: cancer; cell competition; biology; myc ... See more keywords
Transcriptional versus metabolic control of cell fitness during cell competition
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in Cancer Biology"
DOI: 10.1016/j.semcancer.2019.05.010
Abstract: The maintenance of tissue homeostasis and health relies on the efficient removal of damaged or otherwise suboptimal cells. One way this is achieved is through cell competition, a fitness quality control mechanism that eliminates cells… read more here.
Keywords: control; fitness cell; cell competition; cell ... See more keywords
Mechanisms of oncogenic cell competition-Paths of victory.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2019.05.015
Abstract: Cancer is a multistep process. In the early phases of this disease, mutations in oncogenes and tumor suppressors are thought to promote clonal expansion. These mutations can increase cell competitiveness, allowing tumor cells to grow… read more here.
Keywords: mechanisms oncogenic; competition paths; oncogenic cell; cell competition ... See more keywords