Simulations reveal that different responses to cell crowding determine the expansion of p53 and Notch mutant clones in squamous epithelia
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2021.0607
Abstract: During ageing, normal epithelial tissues progressively accumulate clones carrying mutations that increase mutant cell fitness above that of wild-type cells. Such mutants spread widely through the tissues, yet despite this cellular homeostasis and functional integrity… read more here.
Keywords: mutant; cell crowding; p53; p53 notch ... See more keywords
How cell crowding causes cancer cells to spread
Sign Up to like & getrecommendations! Published in 2025 at "eLife"
DOI: 10.7554/elife.106768
Abstract: Cell crowding causes high-grade breast cancer cells to become more invasive by activating a molecular switch that causes the cells to shrink and spread. read more here.
Keywords: causes cancer; cancer cells; cell crowding; crowding causes ... See more keywords