The prolyl hydroxylase OGFOD1 promotes cancer cell proliferation by regulating the expression of cell cycle regulators
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14547
Abstract: OGFOD1, a prolyl‐hydroxylase, has been reported to translocate from the nucleus to the cytoplasm in response to cellular stress. Here, we demonstrate that OGFOD1 regulates the transcription and post‐transcriptional stabilization of cell cycle‐related genes. OGFOD1… read more here.
Keywords: cell; prolyl hydroxylase; cell cycle; cycle regulators ... See more keywords
Targeting of lactate dehydrogenase C dysregulates the cell cycle and sensitizes breast cancer cells to DNA damage response targeted therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13024
Abstract: The cancer testis antigen (CTA) lactate dehydrogenase C (LDHC) is a promising anti-cancer target with tumor-specific expression and immunogenicity. Interrogation of breast cancer patient cohorts from The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of… read more here.
Keywords: dna damage; cell cycle; breast cancer; ldhc ... See more keywords
Bone morphogenetic protein 4 regulates immortalized chicken preadipocyte proliferation by promoting G1/S cell cycle progression
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DOI: 10.1002/2211-5463.12640
Abstract: Bone morphogenetic protein 4 (BMP4) has been reported to regulate adipose development, but its role in preadipocyte proliferation has not been explored in vitro. Here, we investigated the effect of BMP4 on chicken preadipocyte proliferation… read more here.
Keywords: cell cycle; bmp4; preadipocyte proliferation; proliferation ... See more keywords
ETS transcription factor ELF3 (ESE‐1) is a cell cycle regulator in benign and malignant prostate
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DOI: 10.1002/2211-5463.13417
Abstract: This study aimed to elucidate the role of ELF3, an ETS family member in normal prostate growth and prostate cancer. Silencing ELF3 in both benign prostate (BPH‐1) and prostate cancer (PC3) cell lines resulted in… read more here.
Keywords: cycle regulator; prostate; cell cycle; cell ... See more keywords
Suppression of Lung Cancer Malignancy by Micellized siRNA through Cell Cycle Arrest
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202358
Abstract: UBA6‐specific E2 conjugation enzyme 1 (USE1) is frequently overexpressed in lung cancer patients. Moreover, the critical role of USE1 in the progression of human lung cancer is also indicated. As the next step, the authors… read more here.
Keywords: cycle arrest; lung cancer; cell cycle; cancer ... See more keywords
LncRNA UCA1 Antagonizes Arsenic‐Induced Cell Cycle Arrest through Destabilizing EZH2 and Facilitating NFATc2 Expression
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DOI: 10.1002/advs.201903630
Abstract: Abstract Arsenic (As) is a widespread metalloid contaminant, and its internal exposure is demonstrated to cause serious detrimental health problems. Albeit considerable studies are performed to interrogate the molecular mechanisms responsible for As‐induced toxicities, the… read more here.
Keywords: cycle arrest; induced cell; cell cycle; ezh2 ... See more keywords
Novel pyrazolopyrimidine urea derivatives: Synthesis, antiproliferative activity, VEGFR‐2 inhibition, and effects on the cell cycle profile
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DOI: 10.1002/ardp.201900319
Abstract: A series of novel diaryl urea pyrazolopyrimidine derivatives was designed and synthesized. All the synthesized compounds were evaluated for cytotoxic activity by the National Cancer Institute. A significant antiproliferative activity at a 10‐µM dose was… read more here.
Keywords: cell cycle; pyrazolopyrimidine; antiproliferative activity; vegfr ... See more keywords
CHRONOCRISIS: When Cell Cycle Asynchrony Generates DNA Damage in Polyploid Cells
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DOI: 10.1002/bies.202000105
Abstract: Polyploid cells contain multiple copies of all chromosomes. Polyploidization can be developmentally programmed to sustain tissue barrier function or to increase metabolic potential and cell size. Programmed polyploidy is normally associated with terminal differentiation and… read more here.
Keywords: polyploid; dna damage; cell cycle; polyploid cells ... See more keywords
Cell cycle regulators control stemness and differentiation
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DOI: 10.1002/bies.202100123
Abstract: Stem cell proliferation and cellular differentiation need to be tightly coordinated with the mitotic cell cycle. But how is this done at the mechanistic level? How do gene regulatory proteins, such as pluripotency factors and… read more here.
Keywords: stem cell; cell; differentiation; cell cycle ... See more keywords
Induction of endoplasmic reticulum stress is associated with the anti-tumor activity of monepantel across cancer types.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6021
Abstract: BACKGROUND Monepantel is an anti-helminthic drug that also has anti-cancer properties. Despite several studies over the years, the molecular target of monepantel in mammalian cells is still unknown, and its mechanism-of-action is not fully understood,… read more here.
Keywords: cell; monepantel; cell cycle; activity ... See more keywords
TCF19 contributes to cell proliferation of non‐small cell lung cancer by inhibiting FOXO1
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DOI: 10.1002/cbin.11189
Abstract: Transcription factor 19 (TCF19) harbors a forkhead association (FHA) domain, a proline‐rich region, a PHD or RING finger region, suggesting that TCF19 possesses a powerful function. However, its expression and function remains unknown in non‐small‐cell… read more here.
Keywords: cell cycle; proliferation; tcf19; cancer ... See more keywords