In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.70127
Abstract: Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to… read more here.
Keywords: cytotoxicity; vitro modeling; cell; natural killer ... See more keywords
Leucine rich repeats and calponin homology domain containing 1 inhibits NK-92 cell cytotoxicity through attenuating Src signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Immunobiology"
DOI: 10.1016/j.imbio.2020.151934
Abstract: NK-92 cell line has been used as anti-tumor cytotoxic effector cells in immunotherapy. Leucine-rich repeats and calponin homology domain containing 1 (LRCH1) is a novel gene of which the function is unclear. In the present… read more here.
Keywords: tumor; cytotoxicity; cell cytotoxicity; lrch1 knockout ... See more keywords
Comparative mammalian cell cytotoxicity of wastewater with elevated bromide and iodide after chlorination, chloramination, or ozonation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of environmental sciences"
DOI: 10.1016/j.jes.2017.03.030
Abstract: Recycling wastewater is becoming more common as communities around the world try to better control their water resources against an increased frequency of either prolonged droughts or intense flooding. For communities in coastal areas, wastewaters… read more here.
Keywords: chlorination; mammalian cell; cell cytotoxicity; wastewater ... See more keywords
Thiol Reactivity Analyses To Predict Mammalian Cell Cytotoxicity of Water Samples.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental science & technology"
DOI: 10.1021/acs.est.8b01675
Abstract: An in chemico high throughput assay based on N-acetylcysteine was developed and used in conjunction with previous and new mammalian cell cytotoxicity data. Our objective was to derive an empirical equation with confidence levels for… read more here.
Keywords: mammalian cell; water samples; cell cytotoxicity;
Deletion of the TMEM30A gene enables leukemic cell evasion of NK cell cytotoxicity
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2316447121
Abstract: Significance We used a genome-wide CRISPR screen to identify regulators of NK cell cytotoxicity. Deletion of TMEM30A was shown to provide protection to cancer cells from NK cell killing. The encoded protein is a subunit… read more here.
Keywords: gene; cell; deletion tmem30a; cell cytotoxicity ... See more keywords
Expression of KIR2DS1 does not significantly contribute to NK cell cytotoxicity in HLA-C1/C2 heterozygous haplotype B donors
Sign Up to like & getrecommendations! Published in 2017 at "International Immunology"
DOI: 10.1093/intimm/dxx052
Abstract: NK cells are functionally controlled by the killer immunoglobulin-like receptor (KIR) family that comprises inhibitory (iKIR) and activating (aKIR) members. Genetic association studies suggest that donors expressing aKIRs next to iKIRs will be superior donors… read more here.
Keywords: haplotype donors; cell cytotoxicity; significantly contribute; haplotype ... See more keywords
Detection of Free Toxin B in the Stool of Asymptomatic Clostridioides difficile Carriers by the Cell Cytotoxicity Neutralization Assay
Sign Up to like & getrecommendations! Published in 2021 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofab209
Abstract: Abstract Cell cytotoxicity neutralization assay (CCNA) is considered to be a gold standard to diagnose Clostridioides difficile infections. We performed CCNA on 77 consecutive admission screening rectal swabs from asymptomatic toxigenic C. difficile carriers. Thirty-nine… read more here.
Keywords: neutralization assay; clostridioides difficile; cell cytotoxicity; cytotoxicity neutralization ... See more keywords
Suppression of non-muscle myosin II boosts T cell cytotoxicity against tumors
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adp0631
Abstract: Increasing evidence highlights the importance of immune mechanoregulation in establishing and sustaining tumor-specific cytotoxicity required for desirable immunotherapeutic outcomes. However, the molecular connections between mechanobiological inputs and outputs and the designated immune activities remain largely… read more here.
Keywords: muscle myosin; cytotoxicity; cell cytotoxicity; cytotoxicity tumors ... See more keywords
GP73: the key to unlocking immunotherapies efficacy in solid tumors?
Sign Up to like & getrecommendations! Published in 2025 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2025-011989
Abstract: Resident Golgi protein 73 (GP73) is expressed in many healthy tissues, however overexpression is associated with both viral infections and cancer. As an oncoprotein, GP73 drives tumor progression and plays a fundamental role in immune… read more here.
Keywords: gp73; gp73 key; cell; unlocking immunotherapies ... See more keywords
Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/0008-5472.can-25-1890
Abstract: Single-cell phenoscaping of more than 1,000 γδ T-cell and patient-derived organoid cultures shows that cancer cells suppress anticancer γδ T-cell cytotoxicity but γδ T cells can use multimodal killing to overcome immunomodulation. read more here.
Keywords: phenoscaping reveals; cancer; immunomodulation; cell ... See more keywords
Abstract 911: Butyrophilin 3A2 expression plays a critical role in phosphoantigen-mediated γδ T cell cytotoxicity of neuroblastoma cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-911
Abstract: The clinical use of antibodies targeting the diaslganglioside GD2 improved survival and clearly identified a role for immunotherapy in the aggressive pediatric solid tumor neuroblastoma (NB). Even so, the 5-year survival rate for high risk… read more here.
Keywords: cell; role; bt3; cell cytotoxicity ... See more keywords