Association of Cutaneous Immune-Related Adverse Events With Increased Survival in Patients Treated With Anti-Programmed Cell Death 1 and Anti-Programmed Cell Death Ligand 1 Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2021.5476
Abstract: Importance Despite the efficacy of immune checkpoint inhibitors (ICIs), cutaneous immune-related adverse events (cirAEs) occur in 20% to 40% of all treated patients. To our knowledge, little is known about the predictive value of these… read more here.
Keywords: cell death; therapy; programmed cell; anti programmed ... See more keywords
Assessment of Capecitabine and Bevacizumab With or Without Atezolizumab for the Treatment of Refractory Metastatic Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.49040
Abstract: Key Points Question Does targeting programmed cell death 1 or programmed cell death ligand 1 enhance the clinical benefits of anti–vascular endothelial growth factor therapy in patients with refractory metastatic colorectal cancer (mCRC)? Findings In… read more here.
Keywords: programmed cell; capecitabine bevacizumab; cell death; capecitabine ... See more keywords
Identification and functional characterization of a bacterial homologue of Zeta toxin in Leishmania donovani
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13429
Abstract: Zeta‐toxin is a cognate toxin of epsilon antitoxin of prokaryotic Type II toxin‐antitoxin system (TA) and play an important role in cell death. An orthologue of bacterial‐zeta‐toxin (BzT) was identified in Leishmania donovani with similar… read more here.
Keywords: leishmania donovani; zeta toxin; toxin; cell death ... See more keywords
Selective induction of cancer cell death by VDAC1‐based peptides and their potential use in cancer therapy
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12313
Abstract: Mitochondrial VDAC1 mediates cross talk between the mitochondria and other parts of the cell by transporting anions, cations, ATP, Ca2+, and metabolites and serves as a key player in apoptosis. As such, VDAC1 is involved… read more here.
Keywords: cell death; vdac1 based; cancer cell; cancer ... See more keywords
Bcl‐2 inhibitors enhance FGFR inhibitor‐induced mitochondrial‐dependent cell death in FGFR2‐mutant endometrial cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12422
Abstract: Endometrial cancer is the most commonly diagnosed gynaecological malignancy. Unfortunately, 15–20% of women demonstrate persistent or recurrent tumours that are refractory to current chemotherapies. We previously identified activating mutations in fibroblast growth factor receptor 2… read more here.
Keywords: bcl; death; endometrial cancer; cell death ... See more keywords
Targeted inhibition of STAT3 induces immunogenic cell death of hepatocellular carcinoma cells via glycolysis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13263
Abstract: In hepatocellular carcinoma (HCC), the signal transducer and activator of transcription 3 (STAT3) is present in an overactive state that is closely related to tumour development and immune escape. STAT3 inhibition reshapes the tumour immune… read more here.
Keywords: cell death; cell; inhibition; hcc ... See more keywords
The antiviral drug telaprevir induces cell death by reducing FOXA1 expression in estrogen receptor α (ERα)‐positive breast cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13303
Abstract: Previously, we found that telaprevir (Tel), the inhibitor of hepatitis C virus NS3/4A serine protease, reduces estrogen receptor α (ERα) content at the transcriptional level without binding to the receptor, prevents ERα transcriptional activity, and… read more here.
Keywords: cell death; estrogen receptor; breast cancer; induces cell ... See more keywords
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular oncology"
DOI: 10.1002/1878-0261.70124
Abstract: Relapsed/refractory (R/R) disease is a major hurdle to long-term survival of acute myeloid leukemia (AML) patients treated with intensive cytarabine (AraC)-based chemotherapy. R/R AML salvage treatment with venetoclax (VEN) + azacitidine (AZA) results in overall response rates… read more here.
Keywords: cdk9; aml cell; arac; cell death ... See more keywords
Chorein deficiency promotes ferroptosis
Sign Up to like & getrecommendations! Published in 2024 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13870
Abstract: Ferroptosis is a type of programmed cell death owed to an intracellular accumulation of iron resulting in the generation reactive oxygen species, which in turn can cause peroxidation of plasma membrane lipids and ultimately result… read more here.
Keywords: vps13a; chorein deficiency; chorein; ferroptosis ... See more keywords
Polymersomal Poly(I:C) Self‐Magnifies Antitumor Immunity by Inducing Immunogenic Cell Death and Systemic Immune Activation
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202400784
Abstract: Immunotherapy has emerged as a powerful weapon against lung cancer, yet only a fraction of patients respond to the treatment. Poly(I:C) (PIC) effectively triggers both innate and adaptive immunity. It can also induce immunogenic cell… read more here.
Keywords: immunogenic cell; immunity; activation; tumor ... See more keywords
NIR-Triggered Metal-Polyphenol Nanoparticles Enhance HPV-Driven Cancer Immunotherapy via Immunogenic Cell Death and STING Sequential Activation.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202502884
Abstract: HPV-associated malignancies consistently express E6/E7 oncoproteins, making these viral antigens prime targets for therapeutic vaccination. However, insufficient antigen exposure and presentation remain major obstacles for potent immunotherapy. Here, a novel metal-polyphenol network-coated human serum albumin… read more here.
Keywords: polyphenol; metal polyphenol; immunogenic cell; cell death ... See more keywords