Modeling human pancreatic beta cell dedifferentiation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.02.002
Abstract: Objective Dedifferentiation could explain reduced functional pancreatic β-cell mass in type 2 diabetes (T2D). Methods Here we model human β-cell dedifferentiation using growth factor stimulation in the human β-cell line, EndoC-βH1, and human pancreatic islets.… read more here.
Keywords: fgf2; cell dedifferentiation; human pancreatic; expression ... See more keywords
Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2021 at "JCI insight"
DOI: 10.1172/jci.insight.143791
Abstract: Dedifferentiation has been implicated in β cell dysfunction and loss in rodent diabetes. However, the pathophysiological significance in humans remains unclear. To elucidate this, we analyzed surgically resected pancreatic tissues of 26 Japanese subjects with… read more here.
Keywords: cell dedifferentiation; dedifferentiation pathologic; progression; cell ... See more keywords
Virus-like infection induces human β cell dedifferentiation.
Sign Up to like & getrecommendations! Published in 2018 at "JCI insight"
DOI: 10.1172/jci.insight.97732
Abstract: Type 1 diabetes (T1D) is a chronic disease characterized by an autoimmune-mediated destruction of insulin-producing pancreatic β cells. Environmental factors such as viruses play an important role in the onset of T1D and interact with… read more here.
Keywords: virus like; infection; cell dedifferentiation; human cell ... See more keywords
Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in db/db Mice
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DOI: 10.2337/db16-1213
Abstract: β-Cell failure is a hallmark of type 2 diabetes. Among several cellular biological mechanisms of cellular dysfunction, we and others have recently proposed that dedifferentiation of β-cells can explain the slowly progressive onset and partial… read more here.
Keywords: insulin; cell dedifferentiation; pair feeding; dedifferentiation ... See more keywords
The Anna Karenina Model of β-Cell Maturation in Development and Their Dedifferentiation in Type 1 and Type 2 Diabetes
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DOI: 10.2337/db21-0211
Abstract: Loss of mature β-cell function and identity, or β-cell dedifferentiation, is seen in both type 1 and type 2 diabetes. Two competing models explain β-cell dedifferentiation in diabetes. In the first model, β-cells dedifferentiate in… read more here.
Keywords: dedifferentiation; cell dedifferentiation; type diabetes; model ... See more keywords
A Brief Review of the Mechanisms of β-Cell Dedifferentiation in Type 2 Diabetes
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DOI: 10.3390/nu13051593
Abstract: Diabetes is a metabolic disease characterized by hyperglycemia. Over 90% of patients with diabetes have type 2 diabetes. Pancreatic β-cells are endocrine cells that produce and secrete insulin, an essential endocrine hormone that regulates blood… read more here.
Keywords: type diabetes; cell; brief review; cell dedifferentiation ... See more keywords
VNN1 overexpression in pancreatic cancer cells inhibits paraneoplastic islet function by increasing oxidative stress and inducing β‑cell dedifferentiation
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DOI: 10.3892/or.2023.8557
Abstract: Vanin-1 (VNN1) may be a potential biomarker for the early screening of pancreatic cancer (PC)-associated diabetes (PCAD). A previous study by the authors reported that cysteamine secreted by VNN1-overexpressing PC cells induced the dysfunction of… read more here.
Keywords: pancreatic cancer; cell dedifferentiation; oxidative stress;