T cell‐dependent antigen adjuvanted with DOTAP‐CpG‐B but not DOTAP‐CpG‐A induces robust germinal center responses and high affinity antibodies in mice
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201747113
Abstract: The development of vaccines for infectious diseases for which we currently have none, including HIV, will likely require the use of adjuvants that strongly promote germinal center responses and somatic hypermutation to produce broadly neutralizing… read more here.
Keywords: germinal center; center responses; cell dependent; dotap cpg ... See more keywords
Granulomonocytapheresis as a cell‐dependent treatment option for patients with inflammatory bowel disease: Concepts and clinical features for better therapeutic outcomes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21670
Abstract: Ulcerative colitis (UC) and Crohn's disease (CD) are major phenotypes of the chronic inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world with debilitating symptoms. The chronic nature of IBD means that… read more here.
Keywords: bowel disease; inflammatory bowel; granulomonocytapheresis cell; cell dependent ... See more keywords
Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Neuroscience"
DOI: 10.1038/nrn.2017.110
Abstract: The final stage of brain development is associated with the generation and maturation of neuronal synapses. However, the same period is also associated with a peak in synapse elimination — a process known as synaptic… read more here.
Keywords: pruning; glial cell; cell dependent; synaptic pruning ... See more keywords
The roles of IL-17C in T cell-dependent and -independent inflammatory diseases
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34054-x
Abstract: IL-17C, which is a member of the IL-17 family of cytokines, is preferentially produced by epithelial cells in the lung, skin and colon, suggesting that IL-17C may be involved in not only host defense but… read more here.
Keywords: independent inflammatory; cell dependent; inflammatory diseases; roles 17c ... See more keywords
Novel B cell-dependent multiple sclerosis model using extracellular domains of myelin proteolipid protein
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61928-w
Abstract: Therapeutic success of B cell-targeting approaches in multiple sclerosis (MS) has intensified research into the pathogenic and regulatory roles these cells play in demyelinating disease. Dissecting the function of B cells in the MS mouse… read more here.
Keywords: protein; cell dependent; model; multiple sclerosis ... See more keywords
Regulatory B Cell‐Dependent Islet Transplant Tolerance Is Also Natural Killer Cell Dependent
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Transplantation"
DOI: 10.1111/ajt.14265
Abstract: Immunologic tolerance to solid organ and islet cell grafts has been achieved in various rodent models by using antibodies directed at CD45RB and Tim‐1. We have shown that this form of tolerance depends on regulatory… read more here.
Keywords: tolerance; islet; natural killer; cell dependent ... See more keywords
Innate IFN-γ Is Essential for Systemic Chlamydia muridarum Control in Mice, While CD4 T Cell-Dependent IFN-γ Production Is Highly Redundant in the Female Reproductive Tract
Sign Up to like & getrecommendations! Published in 2020 at "Infection and Immunity"
DOI: 10.1128/iai.00541-20
Abstract: Protective immunity against the obligate intracellular bacterium Chlamydia has long been thought to rely on CD4 T cell-dependent gamma interferon (IFN-γ) production. Nevertheless, whether IFN-γ is produced by other cellular sources during Chlamydia infection and… read more here.
Keywords: chlamydia; cell dependent; ifn; cd4 cell ... See more keywords
Bone marrow transplantation generates T cell–dependent control of myeloma in mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Investigation"
DOI: 10.1172/jci98888
Abstract: Transplantation with autologous hematopoietic progenitors remains an important consolidation treatment for patients with multiple myeloma (MM) and is thought to prolong the disease plateau phase by providing intensive cytoreduction. However, transplantation induces inflammation in the… read more here.
Keywords: myeloma; cell dependent; bone marrow; control ... See more keywords
T cell‐dependent bispecific antibodies alter organ‐specific endothelial cell–T cell interaction
Sign Up to like & getrecommendations! Published in 2023 at "EMBO Reports"
DOI: 10.15252/embr.202255532
Abstract: Preclinical and clinical studies demonstrate that T cell‐dependent bispecific antibodies (TDBs) induce systemic changes in addition to tumor killing, leading to adverse events. Here, we report an in‐depth characterization of acute responses to TDBs in… read more here.
Keywords: cell; dependent bispecific; organ specific; endothelial cell ... See more keywords
Response: Commentary: Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00466
Abstract: The commentary by Schroder et al. on our report “Belatacept Does Not Inhibit Follicular T Cell- Dependent B-Cell Differentiation in Kidney Transplantation,” challenges our findings and conclusions by questioning the methodology, definitions and interpretation of… read more here.
Keywords: follicular cell; belatacept inhibit; inhibit follicular; cell dependent ... See more keywords
Soybean Meal-Induced Intestinal Inflammation in Zebrafish Is T Cell-Dependent and Has a Th17 Cytokine Profile
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00610
Abstract: Currently, inflammatory bowel disease (IBD) is a serious public health problem on the rise worldwide. In this work, we utilized the zebrafish to introduce a new model of intestinal inflammation triggered by food intake. Taking… read more here.
Keywords: cell dependent; intestinal inflammation; inflammation; soybean meal ... See more keywords