T‐cell depleted HLA‐haploidentical HSCT in a child with neuromyelitis optica
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50843
Abstract: Neuromyelitis optica is an immune‐mediated disease characterized by a relapsing course, resulting in progressive disability. In children, given the long life expectancy, a disease‐modifying treatment could be particularly desirable. Unfortunately, the currently available treatment strategies… read more here.
Keywords: neuromyelitis optica; cell depleted; hla haploidentical; hsct ... See more keywords
Outcomes of Two Chemotherapy-Based Preparatory Regimens Compared to TBI-Based Conditioning When Used with CD34+ Selected T-Cell Depleted Allohct for High Risk Hematologic Malignancies: Prospective Clinical Trial NCT 01119066
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.582
Abstract: Introduction To assess the therapeutic potential of non-TBI conditioning and T-cell depleted (TCD) allo HCT for high risk malignancies, we conducted a prospective trial comparing: A. our standard 1375 cGy HFTBI + Thiotepa, 5mg/kg/dx2 + cyclophosphamide, 60mg/kg/dx2 vs B.… read more here.
Keywords: cell depleted; age; high risk; arm ... See more keywords
Generation and infusion of multi-antigen-specific T cells to prevent complications early after T-cell depleted allogeneic stem cell transplantation—a phase I/II study
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0600-z
Abstract: Prophylactic infusion of selected donor T cells can be an effective method to restore specific immunity after T-cell-depleted allogeneic stem cell transplantation (TCD-alloSCT). In this phase I/II study, we aimed to reduce the risk of… read more here.
Keywords: infusion; cell depleted; antigen specific; specific cells ... See more keywords
Outcome of αβ T cell-depleted transplantation in children with high-risk acute myeloid leukemia, grafted in remission
Sign Up to like & getrecommendations! Published in 2019 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-019-0531-3
Abstract: Technology of ex-vivo depletion of αβ T cells was developed and applied in the clinic to overcome major barriers, associated with hematopoietic stem cell transplantation (HSCT) from mismatched donors, including graft failure, severe graftversus-host disease… read more here.
Keywords: cell depleted; day day; leukemia; transplantation ... See more keywords
ADCC can improve graft vs leukemia effect after T- and B-cell depleted haploidentical stem cell transplantation in pediatric B-lineage ALL
Sign Up to like & getrecommendations! Published in 2019 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-019-0606-1
Abstract: Posttransplant relapsed B-cell precursor ALL can be cured by 2nd hematopoietic stem cell transplantation (HSCT) in 20% of patients. The major cause of death after second HSCT is leukemic relapse. One reliable predictor for survival… read more here.
Keywords: cell depleted; cell transplantation; hsct; stem cell ... See more keywords
Reconstitution of multifunctional CD56lowCD16low natural killer cell subset in children with acute leukemia given α/β T cell-depleted HLA-haploidentical haematopoietic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1342024
Abstract: ABSTRACT We recently described the CD56lowCD16low subset of Natural Killer (NK) cells that both mediate cytotoxic activity and produce IFNγ, being more abundant in bone marrow (BM) than in peripheral blood (PB) of pediatric normal… read more here.
Keywords: depleted hla; cd56lowcd16low cells; cell depleted; natural killer ... See more keywords
Combination Therapy With Casirivimab/Imdevimab and Remdesivir for Protracted SARS-CoV-2 Infection in B-cell-Depleted Patients
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DOI: 10.1093/ofid/ofac064
Abstract: Abstract Profoundly B-cell-depleted patients can have prolonged severe acute respiratory syndrome coronavirus 2 infections with evidence of active viral replication, due to inability to mount an adequate humoral response to clear the virus. We present… read more here.
Keywords: imdevimab remdesivir; depleted patients; infection; cell depleted ... See more keywords
Administration of BPX-501 Following α-T and B-Cell Depleted Haplo-HSCT in Children with Transfusion-Dependent Thalassemia
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-166
Abstract: Background Allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA-identical sibling has been shown to cure most children with transfusion-dependent b-thalassemia major. Results obtained using an HLA-partially matched (haploidentical, haplo) donor have been historically less… read more here.
Keywords: bpx 501; cell depleted; depleted haplo; haplo hsct ... See more keywords