Assessment of Response to B-Cell Depletion Using Rituximab in Cutaneous Lupus Erythematosus
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2018.3793
Abstract: Importance Cutaneous lupus erythematosus (CLE) can be severe and treatment resistant. B-cell depletion therapy (BCDT) with rituximab is well recognized in organ involvement in systemic lupus erythematosus (SLE), but its efficacy in cutaneous manifestations is… read more here.
Keywords: cell depletion; response; lupus erythematosus; bilag grade ... See more keywords
Evaluation of Clinical Relevance and Biological Effects of Antirituximab Antibodies in Patients With Pemphigus.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2022.2149
Abstract: Importance The clinical relevance of antirituximab antibodies (ARAs) in patients with pemphigus who are treated with rituximab (RTX) is currently unknown. Objective To determine the prevalence of ARAs in patients with pemphigus who are treated… read more here.
Keywords: patients pemphigus; antirituximab antibodies; cell depletion; rtx ... See more keywords
B Cell Depletion and SARS‐CoV‐2 Vaccine Responses in Neuroimmunologic Patients
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DOI: 10.1002/ana.26309
Abstract: The study was undertaken to assess the impact of B cell depletion on humoral and cellular immune responses to severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) vaccination in patients with various neuroimmunologic disorders on anti‐CD20 therapy.… read more here.
Keywords: cell depletion; depletion sars; vaccine responses; sars cov ... See more keywords
Prolonged B-cell depletion after rituximab in AQP4-IgG-positive neuromyelitis optica spectrum disorder
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2021.577666
Abstract: Rituximab (a B-cell depleting monoclonal antibody) is increasingly utilized for treatment of different immune-mediated neurologic disorders, including aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder (AQP4-IgG-NMOSD). After an initial treatment course, the drug is generally reinfused when peripheral… read more here.
Keywords: rituximab; cell depletion; igg positive; cell ... See more keywords
Cytomegalovirus reactivation is associated with a lower rate of early relapse in myeloid malignancies independent of in-vivo T cell depletion strategy.
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia research"
DOI: 10.1016/j.leukres.2017.02.009
Abstract: The association between cytomegalovirus (CMV) reactivation and relapse risk has not been evaluated in relation to T cell depletion strategies. We evaluated 93 patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) and analyzed the… read more here.
Keywords: cmv reactivation; cell depletion; reactivation; relapse ... See more keywords
Depletion of CD20 B cells fails to inhibit relapsing mouse experimental autoimmune encephalomyelitis.
Sign Up to like & getrecommendations! Published in 2017 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2017.03.013
Abstract: BACKGROUND Multiple sclerosis (MS) is often considered to be a CD4, T cell-mediated disease. This is largely based on the capacity of CD4 T cells to induce relapsing experimental autoimmune encephalomyelitis (EAE) in rodents. However,… read more here.
Keywords: cell depletion; autoimmune encephalomyelitis; depletion; cd20 ... See more keywords
Effect of different initial rituximab regimens on B cell depletion in children with autoimmune neurological diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2022.103510
Abstract: BACKGROUND Rituximab (RTX) is a promising B-cell-depleting monoclonal antibody used to treat several autoimmune neurological diseases in children. The RTX administration regimen relies on the reconstitution of B cells in the peripheral blood. OBJECTIVE The… read more here.
Keywords: neurological diseases; rituximab; reconstitution; cell depletion ... See more keywords
Impact of T-cell depletion on outcome of patients undergoing allogeneic hematopoietic cell transplantation for myelodysplastic syndrome
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DOI: 10.1038/s41409-018-0136-2
Abstract: Myelodysplastic syndromes (MDS) are clonal stem cell disorders usually characterized by cytopenia and dysplasia. MDS are usually diagnosed during the sixth decade and are associated with reduced life expectancy, mainly related to transformation to acute… read more here.
Keywords: cell depletion; stem cell; transplantation; partial cell ... See more keywords
Impact of in vivo T-cell depletion in patients with myelodysplastic syndromes undergoing allogeneic hematopoietic stem cell transplant: a registry study from the Chronic Malignancies Working Party of the EBMT
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DOI: 10.1038/s41409-022-01620-x
Abstract: While in vivo T-cell depletion (TCD) is widely used, its benefit in patients with MDS still remains a matter of debate. This study evaluates the impact of TCD on outcomes, and compares ATG and alemtuzumab,… read more here.
Keywords: study; vivo cell; cell depletion; cell ... See more keywords
Ex vivo and in vivo T-cell depletion in allogeneic transplantation: towards less or non-cytotoxic conditioning regimens
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2022.2134857
Abstract: ABSTRACT Introduction Although tremendous progress has been made since the introduction of allogeneic hematopoietic stem cell transplantation (HSCT) decades ago, there are still many obstacles to overcome. A major obstacle is the presence of T-lymphocytes… read more here.
Keywords: cell; cell depletion; depletion; vivo cell ... See more keywords
Transient NK Cell Depletion Facilitates Pulmonary Osteosarcoma Metastases After Intravenous Inoculation in Athymic Mice.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of adolescent and young adult oncology"
DOI: 10.1089/jayao.2019.0172
Abstract: Two thirds of metastatic osteosarcoma patients die within 5 years of diagnosis. Improved experimental models of osteosarcoma metastasis will facilitate the development of more effective therapies. Intravenous cancer cell injection can produce lung metastases in… read more here.
Keywords: cell depletion; cell; osteosarcoma; metastasis ... See more keywords