Severe Maternal Morbidity and Mortality in Sickle Cell Disease in the National Inpatient Sample, 2012-2018
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DOI: 10.1001/jamanetworkopen.2022.54552
Abstract: Key Points Question What are the rates of and risks for severe maternal morbidity (SMM) among birthing people with sickle cell disease (SCD), and what proportion of the increased risk for adverse pregnancy outcomes in… read more here.
Keywords: people scd; deliveries among; severe maternal; maternal morbidity ... See more keywords
Acute pain in adolescents and young adults with sickle cell disease: Delayed and increased opioid dosing following transition to adult care
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DOI: 10.1002/ajh.24647
Abstract: The transition from pediatric to adult care is a high risk time for adolescent and young adult (AYA) patients with sickle cell disease (SCD). Management of acute pain is a major point of contact between… read more here.
Keywords: adult; transition; adult care; cell disease ... See more keywords
The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso‐occlusive crises
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24750
Abstract: Sickle Cell Disease (SCD) is a painful, lifelong hemoglobinopathy inherited as a missense point mutation in the hemoglobin (Hb) beta‐globin gene. This disease has significant impact on quality of life and mortality, thus a substantial… read more here.
Keywords: occlusive crises; heme; vaso occlusive; disease ... See more keywords
Critical role of C5a in sickle cell disease
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DOI: 10.1002/ajh.25384
Abstract: Innate immune complement activation may contribute to sickle cell disease (SCD) pathogenesis. Ischemia‐reperfusion physiology is a key component of the inflammatory and vaso‐occlusive milieu in SCD and is associated with complement activation. C5a is an… read more here.
Keywords: cell disease; stasis; mice; c5a ... See more keywords
Erythrocyte ATP, a possible therapeutic approach for sickle cell disease
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DOI: 10.1002/ajh.25419
Abstract: This letter presents some suggestions of possible therapies for sickle cell disease that are based on interpretations of presumed effects of different substrates that alter the cellular levels of ATP. A prevailing idea is that… read more here.
Keywords: atp; pyruvate; cell disease; sickle ... See more keywords
Heritability of fetal hemoglobin, white cell count, and other clinical traits from a sickle cell disease family cohort
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25421
Abstract: Sickle cell disease (SCD) is the most common monogenic disorder in the world. Notably, there is extensive clinical heterogeneity in SCD that cannot be fully accounted for by known factors, and in particular, the extent… read more here.
Keywords: family; cohort; cell disease; heritability ... See more keywords
Patient‐reported outcomes in sickle cell disease and association with clinical and psychosocial factors: Report from the sickle cell disease implementation consortium
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DOI: 10.1002/ajh.25880
Abstract: Understanding patient experiences, quality of life, and treatment needs in individuals with sickle cell disease (SCD) is essential in promoting health and well‐being. We used measures from the Adult Sickle Cell Quality of Life Measurement… read more here.
Keywords: cell; cell disease; sickle cell; sleep impact ... See more keywords
The CYB5R3c.350C>G and G6PD A alleles modify severity of anemia in malaria and sickle cell disease
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DOI: 10.1002/ajh.25941
Abstract: Genetic modifiers of anemia in Plasmodium falciparum infection and sickle cell disease (SCD) are not fully known. Both conditions are associated with oxidative stress, hemolysis and anemia. The CYB5R3 gene encodes cytochrome b5 reductase 3,… read more here.
Keywords: g6pd; anemia; cyb5r3c 350c; cell disease ... See more keywords
Reduced global cerebral oxygen metabolic rate in sickle cell disease and chronic anemias
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DOI: 10.1002/ajh.26203
Abstract: Anemia is the most common blood disorder in the world. In patients with chronic anemia, such as sickle cell disease or major thalassemia, cerebral blood flow increases to compensate for decreased oxygen content. However, the… read more here.
Keywords: oxygen; cell disease; sickle cell;
Voxelotor in sickle cell disease
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DOI: 10.1002/ajh.26549
Abstract: A 45-year-old woman with sickle cell/ß thalassemia due to the HBB :c.92 + 5G>C severe ß + thalassemia mutation, who had been on a clinical trial of voxelotor for 4 years was assessed clinically and… read more here.
Keywords: cell; voxelotor; sickle; cell disease ... See more keywords
Hepato‐splenic abscesses in a sickle cell disease patient
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DOI: 10.1002/ajh.26597
Abstract: A 30-year-old woman was admitted to our unit for fever associated with bilateral basothoracic pain. She genotype She secondary hemochromatosis with iron with Hydroxy-urea she the end-stage She to We a low of corticosteroids the… read more here.
Keywords: splenic abscesses; abscesses sickle; disease patient; hepato splenic ... See more keywords