Erythrocyte pyruvate kinase activation in red cell disorders
Sign Up to like & getrecommendations! Published in 2023 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000758
Abstract: Purpose of review In red cells, pyruvate kinase is a key enzyme in the final step of glycolytic degradative process, which generates a constant energy supply via ATP production. This commentary discusses recent findings on… read more here.
Keywords: red cell; kinase activators; cell disorders; kinase ... See more keywords
How do we manage t(11;14) plasma cell disorders with venetoclax?
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18243
Abstract: The oral BCL‐2 inhibitor venetoclax has demonstrated promising efficacy in patients with t(11;14) plasma cell disorders, both as a single‐agent and in combination. However, there was an increased mortality signal in the randomized BELLINI trial… read more here.
Keywords: manage plasma; cell; cell disorders; plasma cell ... See more keywords
Time to apply a social determinants of health lens to addressing sickle cell disorders in sub-Saharan Africa
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DOI: 10.1136/bmjgh-2020-002601
Abstract: ### Summary box Why do sickle cell disorders (SCDs) remain a low priority on the global child health agenda when a child dies from the condition every three seconds globally? Why are more resources not… read more here.
Keywords: health; time apply; sickle cell; cell disorders ... See more keywords
Prevalence of sickle cell disorders and malaria infection in children aged 1–12 years in the Volta Region, Ghana: a community-based study
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DOI: 10.1186/s12936-020-03500-5
Abstract: Background Alterations in the structure of haemoglobin (Hb) are usually brought about by point mutations affecting one or, in some cases, two codons encoding amino acids of the globin chains. One in three Ghanaians are… read more here.
Keywords: cell; sickle cell; cell disorders; prevalence sickle ... See more keywords