Mass spectrometry investigation of DNA adduct formation from bisphenol A quinone metabolite and MCF-7 cell DNA.
Sign Up to like & getrecommendations! Published in 2018 at "Talanta"
DOI: 10.1016/j.talanta.2018.02.037
Abstract: Bisphenol A (BPA) is a widely used additive in the plastic industry and has been reported to have genotoxicity. A hypothesis that BPA may enhance breast cancer risk through the formation of its metabolic intermediate… read more here.
Keywords: bpa; mcf cell; cell dna; dna ... See more keywords
Oral Cell DNA Adducts as Potential Biomarkers for Lung Cancer Susceptibility in Cigarette Smokers.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.6b00372
Abstract: This perspective considers the use of oral cell DNA adducts, together with exposure and genetic information, to potentially identify those cigarette smokers at highest risk for lung cancer, so that appropriate preventive measures could be… read more here.
Keywords: oral cell; cell dna; dna; cancer ... See more keywords
Tracking Decitabine Incorporation into Malignant Myeloid Cell DNA in vitro and in vivo by LC-MS/MS with Enzymatic Digestion
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41070-y
Abstract: The DNA hypomethylating agents decitabine and 5-azacytidine are the only two drugs approved for treatment of all subtypes of the myeloid malignancy myelodysplastic syndromes (MDS). The key to drug activity is incorporation into target cell… read more here.
Keywords: cell dna; dna; digestion; incorporation ... See more keywords
Clonal Evolution and Changes in Two AML Patients Detected with A Novel Single-Cell DNA Sequencing Platform
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47297-z
Abstract: Next-generation sequencing (NGS) is used to detect gene variants in genetically complex cell populations of cancer patient samples. Traditional bulk analysis can only provide average variant allele frequencies of the targeted genes across all sampled… read more here.
Keywords: single cell; cell dna; dna sequencing; novel single ... See more keywords
doubletD: detecting doublets in single-cell DNA sequencing data
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab266
Abstract: Abstract Motivation While single-cell DNA sequencing (scDNA-seq) has enabled the study of intratumor heterogeneity at an unprecedented resolution, current technologies are error-prone and often result in doublets where two or more cells are mistaken for… read more here.
Keywords: single cell; scdna seq; cell dna; seq data ... See more keywords
SimSCSnTree: a simulator of single-cell DNA sequencing data.
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac169
Abstract: MOTIVATION We report on a new single-cell DNA sequence simulator, SimSCSnTree, which generates an evolutionary tree of cells and evolves single nucleotide variants (SNVs) and copy number aberrations (CNAs) along its branches. Data generated by… read more here.
Keywords: cell dna; single cell; simscsntree simulator; cell ... See more keywords
Abstract 861: Improvements in variant calling sensitivity and specificity in single-cell DNA sequencing using deep learning
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-861
Abstract: Background: It is now possible to interrogate thousands of cells in a single experiment for studying genetic variability with the advancements in single-cell sequencing technologies. Single-cell DNA platforms like Tapestri is still susceptible to errors… read more here.
Keywords: single cell; cell; deep learning; cell dna ... See more keywords
A New Valuable Technique in Diagnosis and Treatment Monitoring of Myeloproliferative Neoplasms
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-128709
Abstract: Introduction: Tumor-derived fragmentary DNA, known as circulating tumor DNA (ctDNA), is applied in the diagnosis and treatment of solid tumors maturely now, and also great progress has been achieved in the application of ctDNA to… read more here.
Keywords: ctdna; cell dna; diagnosis; dna ... See more keywords
HeLa-CCL2 cell heterogeneity studied by single-cell DNA and RNA sequencing
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0225466
Abstract: The HeLa cells are the earliest and mostly used laboratory human cells for biomedical particularly cancer research. They were derived from a patient’s cervical cancerous tissue, and are known for their heterogeneous cellular origin and… read more here.
Keywords: single cell; cell dna; hela ccl2; heterogeneity ... See more keywords
SCClone: Accurate Clustering of Tumor Single-Cell DNA Sequencing Data
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.823941
Abstract: Single-cell DNA sequencing (scDNA-seq) enables high-resolution profiling of genetic diversity among single cells and is especially useful for deciphering the intra-tumor heterogeneity and evolutionary history of tumor. Specific technical issues such as allele dropout, false-positive… read more here.
Keywords: tumor; dna sequencing; single cell; scclone ... See more keywords
Introduction to Single-Cell DNA Methylation Profiling Methods
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11071013
Abstract: DNA methylation is an epigenetic mechanism that is related to mammalian cellular differentiation, gene expression regulation, and disease. In several studies, DNA methylation has been identified as an effective marker to identify differences between cells.… read more here.
Keywords: single cell; methylation; cell dna; methylation profiling ... See more keywords