Unrelated Donor Cord Blood Transplantation in Children: Lessons Learned Over 3 Decades
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DOI: 10.1093/stcltm/szac079
Abstract: Abstract Four decades ago, Broxmeyer et al. demonstrated that umbilical cord blood (CB) contained hematopoietic stem cells (HSC) and hypothesized that CB could be used as a source of donor HSC for rescue of myeloablated… read more here.
Keywords: cord; time; unrelated donor; cord blood ... See more keywords
Impact of CD34+ cell dose on reduced intensity conditioning regimen haploidentical hematopoietic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Haematology"
DOI: 10.1111/ejh.13332
Abstract: Haploidentical hematopoietic stem cell transplant (haplo‐SCT) has been associated with higher rates of graft rejection, and a higher dose of CD34+ cell dose is frequently requested. We aim to explore the impact of CD34+ cell… read more here.
Keywords: cd34 cell; haploidentical hematopoietic; stem cell; cell dose ... See more keywords
Effects of CD34+ cell dose on haematopoietic recovery in acute lymphoblastic leukaemia patients with positive pretransplant measurable residual disease
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DOI: 10.1111/ijlh.13974
Abstract: A higher CD34+ cell dose in allografts is associated with faster haematopoietic recovery after allogeneic haematopoietic stem cell transplantation (allo‐HSCT). Leukaemia stem cells impair normal bone marrow (BM) niches and induce BM failure during leukemogenesis.… read more here.
Keywords: cell; leukaemia; haematopoietic recovery; cd34 cell ... See more keywords
Use of low cell dose for unmanipulated donor lymphocyte for management of cytomegalovirus infection: A single‐center experience
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DOI: 10.1111/petr.13882
Abstract: Although advancements have been made in monitoring and preventing viral infections in HSCT patients, CMV reactivation still remains a critical post‐transplant complication. Adoptive cell therapy is an alternative to pharmacotherapy of CMV infection in refractory… read more here.
Keywords: cmv; infection; donor; cell dose ... See more keywords
Ligand-inducible, prostate stem cell antigen (PSCA)-directed GoCAR-T cells in advanced solid tumors: Preliminary results from a dose escalation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.4_suppl.283
Abstract: 283 Background: PSCA, a cell surface protein, is upregulated in many solid tumors and correlates with disease stage. BPX601 is an autologous, T-cell product engineered to contain a PSCA-CD3ζ CAR plus the small molecule rimiducid… read more here.
Keywords: cell dose; dose escalation; solid tumors; cell ... See more keywords