Reversing T Cell Dysfunction to Boost Glioblastoma Immunotherapy by Paroxetine‐Mediated GRK2 Inhibition and Blockade of Multiple Checkpoints through Biomimetic Nanoparticles
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204961
Abstract: T cell dysfunction‐induced tumor immune escape is particularly severe in glioblastoma (GBM), and significantly affects the efficacy of immunotherapy. It is crucial to innovatively reverse the T cell dysfunction for improving GBM immunotherapy. Herein, T… read more here.
Keywords: cell; cell dysfunction; biomimetic nanoparticles; immunotherapy ... See more keywords
Preventive Effects of Thermosensitive Biopolymer-Conjugated C-Peptide against High Glucose-Induced Endothelial Cell Dysfunction.
Sign Up to like & getrecommendations! Published in 2019 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201900129
Abstract: C-peptide has emerged as a potential drug for treating diabetic complications. However, clinical application of C-peptide is limited by its short half-life during circulation and costly synthesis methods. To overcome these limitations, a biocompatible and… read more here.
Keywords: thermosensitive biopolymer; cell dysfunction; peptide high; endothelial cell ... See more keywords
Relationship of NADPH Oxidase-1 expression to beta cell dysfunction induced by inflammatory cytokines.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.02.089
Abstract: Redox stress related loss of beta cell function is a feature of diabetes. Exposure of beta cells and islets to inflammatory mediators elevates reactive oxygen species (ROS) and beta cell dysfunction. Direct molecular manipulation of… read more here.
Keywords: nadph oxidase; cell dysfunction; beta cell; beta ... See more keywords
Impairment of endoplasmic reticulum is involved in β-cell dysfunction induced by microcystin-LR.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental pollution"
DOI: 10.1016/j.envpol.2017.01.061
Abstract: Microcystins (MCs) widely distributed in freshwaters have posed a significant risk to human health. Previous studies have demonstrated that exposure to MC-LR impairs pancreatic islet function, however, the underlying mechanisms still remain unclear. In the… read more here.
Keywords: impairment endoplasmic; cell dysfunction; cell; endoplasmic reticulum ... See more keywords
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.11.003
Abstract: Summary CD4+ T cells orchestrate immune responses and destruction of allogeneic organ transplants, but how this process is regulated on a transcriptional level remains unclear. Here, we demonstrated that interferon regulatory factor 4 (IRF4) was… read more here.
Keywords: irf4; cell dysfunction; cell; cd4 cell ... See more keywords
Metabolic reprogramming orchestrates CD4+ T-cell immunological status and restores cardiac dysfunction in autoimmune induced-dilated cardiomyopathy mice.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.08.002
Abstract: Cellular autoimmune responses, especially those mediated by T-cells, play vital roles in the immunopathogenesis of dilated cardiomyopathy (DCM). Metabolic reprogramming directly controls T-cell function, imprinting distinct functional fates. However, its contribution to T-cell dysfunction and… read more here.
Keywords: cell dysfunction; metabolic reprogramming; autoimmune induced; dysfunction ... See more keywords
Pancreatic INS-1 β-Cell Response to Thapsigargin and Rotenone: A Comparative Proteomics Analysis Uncovers Key Pathways of β-Cell Dysfunction.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00058
Abstract: Insulin-secreting β-cells in the pancreatic islets are exposed to various endogenous and exogenous stressing conditions, which may lead to β-cell dysfunction or apoptosis and ultimately to diabetes mellitus. However, the detailed molecular mechanisms underlying β-cell's… read more here.
Keywords: thapsigargin rotenone; cell; cell dysfunction;
Liver-infiltrating CD11b−CD27− NK subsets account for NK-cell dysfunction in patients with hepatocellular carcinoma and are associated with tumor progression
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Immunology"
DOI: 10.1038/cmi.2016.28
Abstract: Natural killer (NK) cells have a vital role in killing hepatocellular carcinoma (HCC) cells; however, the mechanism underlying tumor-infiltrating NK (TINK)-cell dysfunction remains poorly understood. Using flow cytometry staining, we precisely characterized the frequency, phenotype… read more here.
Keywords: hepatocellular carcinoma; cell dysfunction; dysfunction; cd27 subsets ... See more keywords
CD4 T cell dysfunction is associated with bacterial recrudescence during chronic tuberculosis
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-57819-1
Abstract: While most people contain Mycobacterium tuberculosis infection, some individuals develop active disease, usually within two years of infection. Why immunity fails after initially controlling infection is unknown. C57BL/6 mice control Mycobacterium tuberculosis for up to… read more here.
Keywords: cell dysfunction; cell; cd4 cell; tuberculosis ... See more keywords
Early NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-025-60941-9
Abstract: Dengue is a mosquito-borne virus infection affecting half of the world’s population for which therapies are lacking. The role of T and NK-cells in protection/immunopathogenesis remains unclear for dengue. We performed a longitudinal phenotypic, functional… read more here.
Keywords: dengue; dengue patients; severe dengue; cell dysfunction ... See more keywords
New drug target identified for β-cell dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-022-00658-7
Abstract: New drug target identified for βcell dysfunction βCell dysfunction characterises type 2 diabetes mellitus (T2DM) and ageing. New research in Nature Metabolism identified microsomal prostaglandin E synthase-2 (mPGES2) as a factor that could be targeted… read more here.
Keywords: target identified; cell dysfunction; drug target; cell ... See more keywords