Reversing T Cell Dysfunction to Boost Glioblastoma Immunotherapy by Paroxetine‐Mediated GRK2 Inhibition and Blockade of Multiple Checkpoints through Biomimetic Nanoparticles
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204961
Abstract: T cell dysfunction‐induced tumor immune escape is particularly severe in glioblastoma (GBM), and significantly affects the efficacy of immunotherapy. It is crucial to innovatively reverse the T cell dysfunction for improving GBM immunotherapy. Herein, T… read more here.
Keywords: cell; cell dysfunction; biomimetic nanoparticles; immunotherapy ... See more keywords
Preventive Effects of Thermosensitive Biopolymer-Conjugated C-Peptide against High Glucose-Induced Endothelial Cell Dysfunction.
Sign Up to like & getrecommendations! Published in 2019 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201900129
Abstract: C-peptide has emerged as a potential drug for treating diabetic complications. However, clinical application of C-peptide is limited by its short half-life during circulation and costly synthesis methods. To overcome these limitations, a biocompatible and… read more here.
Keywords: thermosensitive biopolymer; cell dysfunction; peptide high; endothelial cell ... See more keywords
Relationship of NADPH Oxidase-1 expression to beta cell dysfunction induced by inflammatory cytokines.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.02.089
Abstract: Redox stress related loss of beta cell function is a feature of diabetes. Exposure of beta cells and islets to inflammatory mediators elevates reactive oxygen species (ROS) and beta cell dysfunction. Direct molecular manipulation of… read more here.
Keywords: nadph oxidase; cell dysfunction; beta cell; beta ... See more keywords
Impairment of endoplasmic reticulum is involved in β-cell dysfunction induced by microcystin-LR.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental pollution"
DOI: 10.1016/j.envpol.2017.01.061
Abstract: Microcystins (MCs) widely distributed in freshwaters have posed a significant risk to human health. Previous studies have demonstrated that exposure to MC-LR impairs pancreatic islet function, however, the underlying mechanisms still remain unclear. In the… read more here.
Keywords: impairment endoplasmic; cell dysfunction; cell; endoplasmic reticulum ... See more keywords
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.11.003
Abstract: Summary CD4+ T cells orchestrate immune responses and destruction of allogeneic organ transplants, but how this process is regulated on a transcriptional level remains unclear. Here, we demonstrated that interferon regulatory factor 4 (IRF4) was… read more here.
Keywords: irf4; cell dysfunction; cell; cd4 cell ... See more keywords
Metabolic reprogramming orchestrates CD4+ T-cell immunological status and restores cardiac dysfunction in autoimmune induced-dilated cardiomyopathy mice.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.08.002
Abstract: Cellular autoimmune responses, especially those mediated by T-cells, play vital roles in the immunopathogenesis of dilated cardiomyopathy (DCM). Metabolic reprogramming directly controls T-cell function, imprinting distinct functional fates. However, its contribution to T-cell dysfunction and… read more here.
Keywords: cell dysfunction; metabolic reprogramming; autoimmune induced; dysfunction ... See more keywords
Pancreatic INS-1 β-Cell Response to Thapsigargin and Rotenone: A Comparative Proteomics Analysis Uncovers Key Pathways of β-Cell Dysfunction.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00058
Abstract: Insulin-secreting β-cells in the pancreatic islets are exposed to various endogenous and exogenous stressing conditions, which may lead to β-cell dysfunction or apoptosis and ultimately to diabetes mellitus. However, the detailed molecular mechanisms underlying β-cell's… read more here.
Keywords: thapsigargin rotenone; cell; cell dysfunction;
Liver-infiltrating CD11b−CD27− NK subsets account for NK-cell dysfunction in patients with hepatocellular carcinoma and are associated with tumor progression
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Immunology"
DOI: 10.1038/cmi.2016.28
Abstract: Natural killer (NK) cells have a vital role in killing hepatocellular carcinoma (HCC) cells; however, the mechanism underlying tumor-infiltrating NK (TINK)-cell dysfunction remains poorly understood. Using flow cytometry staining, we precisely characterized the frequency, phenotype… read more here.
Keywords: hepatocellular carcinoma; cell dysfunction; dysfunction; cd27 subsets ... See more keywords
New drug target identified for β-cell dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-022-00658-7
Abstract: New drug target identified for βcell dysfunction βCell dysfunction characterises type 2 diabetes mellitus (T2DM) and ageing. New research in Nature Metabolism identified microsomal prostaglandin E synthase-2 (mPGES2) as a factor that could be targeted… read more here.
Keywords: target identified; cell dysfunction; drug target; cell ... See more keywords
Microparticles from β-thalassaemia/HbE patients induce endothelial cell dysfunction
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31386-6
Abstract: Thromboembolic complication occurs frequently in β-thalassaemia/HbE patients, particularly in splenectomised patients. Endothelial cells play an important role in thrombosis. There is strong evidence of endothelial cell activation and dysfunction in β-thalassaemia. Microparticles (MPs) are associated… read more here.
Keywords: cell dysfunction; hbe patients; endothelial cell; cell ... See more keywords
Dysregulation of the Wnt signaling pathway and synovial stem cell dysfunction in osteoarthritis development.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cells and development"
DOI: 10.1089/scd.2019.0260
Abstract: Stem cell dysfunction and failure have been found in joints afflicted by osteoarthritis (OA). However, the exact factors in the OA microenvironment that impair stem cell functions and the role of stem cell dysfunction in… read more here.
Keywords: cell dysfunction; wnt signaling; stem cell; stem ... See more keywords