Using CRISPR to enhance T cell effector function for therapeutic applications
Sign Up to like & getrecommendations! Published in 2021 at "Cytokine"
DOI: 10.1016/j.cytox.2020.100049
Abstract: T cells are critical to fight pathogenic microbes and combat malignantly transformed cells in the fight against cancer. To exert their effector function, T cells produce effector molecules, such as the pro-inflammatory cytokines IFN-γ, TNF-α… read more here.
Keywords: enhance cell; cell; effector function; effector ... See more keywords
Control of Metastases via Myeloid CD39 and NK Cell Effector Function
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-19-0749
Abstract: A CD39-targeting monoclonal antibody (B66) has potent activity in experimental and spontaneous metastases models. Myeloid cell, but not NK cell, expression of CD39 is critical for efficacy of the antibody and NK cell–mediated control of… read more here.
Keywords: anti cd39; cd39; control metastases; cell effector ... See more keywords
Docosahexaenoic acid supplementation represses the early immune response against murine cytomegalovirus but enhances NK cell effector function
Sign Up to like & getrecommendations! Published in 2022 at "BMC Immunology"
DOI: 10.1186/s12865-022-00492-6
Abstract: Background Docosahexaenoic acid (DHA) supplementation is beneficial for several chronic diseases; however, its effect on immune regulation is still debated. Given the prevalence of cytomegalovirus (CMV) infection and because natural killer (NK) cells are a… read more here.
Keywords: dha; mice; response; infection ... See more keywords
Targeting TRIM29 As a Negative Regulator of CAR-NK Cell Effector Function to Improve Antitumor Efficacy of These Cells: A Perspective.
Sign Up to like & getrecommendations! Published in 2023 at "Current molecular medicine"
DOI: 10.2174/1566524023666230510101525
Abstract: Natural killer (NK) cells are among the most important cells in innate immune defense. In contrast to T cells, the effector function of NK cells does not require prior stimulation and is not MHC restricted.… read more here.
Keywords: cell; effector function; car; cell effector ... See more keywords