Bispecific T‐cell engagers for treatment of multiple myeloma
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26628
Abstract: Bispecific T cell engagers (TCE) derive from monoclonal antibodies and concomitantly engage a target on the surface of cancer cell and CD3 on the surface of T‐cells. TCEs promote T cell activation and lysis of… read more here.
Keywords: cell engagers; cell; multiple myeloma; bispecific cell ... See more keywords
Bispecific light T-cell engagers for gene-based immunotherapy of epidermal growth factor receptor (EGFR)-positive malignancies
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-018-2181-5
Abstract: The recruitment of T-cells by bispecific antibodies secreted from adoptively transferred, gene-modified autologous cells has shown satisfactory results in preclinical cancer models. Even so, the approach’s translation into the clinic will require incremental improvements to… read more here.
Keywords: light cell; cell engagers; based immunotherapy; gene based ... See more keywords
T cell engagers in solid tumors kick the door down.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer cell"
DOI: 10.1016/j.ccell.2021.10.005
Abstract: Tebentafusp, a T cell-redirecting, bispecific-antibody-targeting, HLA∗02:01-restricted gp100 peptide and CD3, induces T cells to kill glycoprotein 100 (gp100)-expressing tumor cells. Tebentafusp is the first T cell engager to show a statistically significant overall survival improvement for the treatment… read more here.
Keywords: engagers solid; solid tumors; cell engagers; tumors kick ... See more keywords
Conditionally active T cell engagers for the treatment of solid tumors: rationale and clinical development
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2022.2098674
Abstract: ABSTRACT Introduction T cell engagers are a class of bispecific molecules that induce highly potent T cell-dependent cytotoxicity by bringing T cell activating receptors into proximity with cancer-associated cell surface antigens. However, because of their… read more here.
Keywords: cell; development; active cell; solid tumors ... See more keywords
Development of T-cell engagers selective for cells co-expressing two antigens
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2115213
Abstract: ABSTRACT T cell-engaging bispecific antibodies (TCEs) are clinically effective treatments for hematological cancers. While the utility of TCEs in solid malignancies is being explored, toxicities arising from antigen expression on normal tissues have slowed or… read more here.
Keywords: cell; development; expressing two; cells expressing ... See more keywords
Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2034355
Abstract: ABSTRACT Retargeting of T lymphocytes toward cancer cells by bispecific antibodies has demonstrated its therapeutic potential, with one such antibody approved for the treatment of acute lymphoblastic leukemia (blinatumomab) and several other in clinical trials.… read more here.
Keywords: cancer; cell engagers; tumor; cell ... See more keywords
Dissecting the mechanism of cytokine release induced by T-cell engagers highlights the contribution of neutrophils
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2039432
Abstract: ABSTRACT T cell engagers represent a novel promising class of cancer-immunotherapies redirecting T cells to tumor cells and have some promising outcomes in the clinic. These molecules can be associated with a mode-of-action related risk… read more here.
Keywords: cytokine release; cell engagers; contribution neutrophils; cell ... See more keywords
Generalizable design parameters for soluble T cell receptor-based T cell engagers
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004281
Abstract: While most biological and cellular immunotherapies recognize extracellular targets, T cell receptor (TCR) therapeutics are unique in their ability to recognize the much larger pool of intracellular antigens found on virus-infected or cancerous cells. Recombinant… read more here.
Keywords: cell; rtcr; cell receptor; cell engagers ... See more keywords
Abstract 3641: EGFR/CD16A TandAbs are efficacious NK-cell engagers with favorable biological properties which potently kill EGFR+ tumors with and without Ras mutation
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-3641
Abstract: Constitutive EGFR activation plays an important role in the pathophysiology of various solid cancers, such as colorectal cancer, non-small cell lung cancer or squamous cell carcinomas of the head and neck. Tyrosine kinase inhibitors (TKI)… read more here.
Keywords: egfr; egfr cd16a; cell engagers; cell ... See more keywords
Abstract 1890: Bispecific T cell engagers targeting TrkB
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1890
Abstract: Tropomyosin kinase B (TrkB) plays an important role in survival, differentiation, and proliferation of neural cells. It belongs to the family of receptor tyrosine kinases and its specific ligands are NT-4/5 and BDNF. The (over)expression… read more here.
Keywords: cell; engagers targeting; targeting trkb; bispecific ... See more keywords
Abstract 1891: Breaking barriers to access intracellular targets with T-cell engagers: Discovery of diverse, developable, and ultra-specific antibodies against a MAGE-A4 pMHC
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1891
Abstract: In this study, we describe the discovery of antibodies against a MAGE-A4 peptide-major histocompatibility complex (pMHC). These antibodies will form the basis for the tumor-binding arm of T-cell engagers (TCEs) against this target. Bispecific CD3… read more here.
Keywords: ultra specific; antibodies mage; access intracellular; diverse developable ... See more keywords