Lose the Stress: Viscoelastic Materials for Cell Engineering.
Sign Up to like & getrecommendations! Published in 2022 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2022.03.058
Abstract: Biomaterials are widely used to study and control a variety of cell behaviors, including stem cell differentiation, organogenesis, and tumor invasion. While considerable attention has historically been paid to biomaterial elastic properties, it has recently… read more here.
Keywords: materials cell; cell engineering; viscoelastic properties; viscoelastic materials ... See more keywords
Cell engineering: Biophysical regulation of the nucleus.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.119743
Abstract: Cells live in a complex and dynamic microenvironment, and a variety of microenvironmental cues can regulate cell behavior. In addition to biochemical signals, biophysical cues can induce not only immediate intracellular responses, but also long-term… read more here.
Keywords: nucleus; engineering biophysical; cell engineering; biophysical regulation ... See more keywords
Ionizable Lipid Nanoparticle Mediated mRNA Delivery for Human CAR T Cell Engineering.
Sign Up to like & getrecommendations! Published in 2020 at "Nano letters"
DOI: 10.1021/acs.nanolett.9b04246
Abstract: CAR T cell therapy relies on the ex vivo manipulation of patient T cells to create a potent, cancer-targeting therapy, shown to be capable of inducing remission in patients with acute lymphoblastic leukemia and large… read more here.
Keywords: car cell; cell engineering; mrna delivery; cell ... See more keywords
Cell engineering: How to hack the genome
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/547477a
Abstract: After tackling the genomes of bacteria and yeast, synthetic biologists are setting their sights on rewriting those of more complex organisms, including humans. read more here.
Keywords: cell engineering; engineering hack; hack genome;
A systems biology pipeline identifies regulatory networks for stem cell engineering
Sign Up to like & getrecommendations! Published in 2019 at "Nature Biotechnology"
DOI: 10.1038/s41587-019-0159-2
Abstract: A major challenge for stem cell engineering is achieving a holistic understanding of the molecular networks and biological processes governing cell differentiation. To address this challenge, we describe a computational approach that combines gene expression… read more here.
Keywords: pipeline; cell engineering; stem cell; biology ... See more keywords
Recent advances in the production of recombinant factor IX: bioprocessing and cell engineering
Sign Up to like & getrecommendations! Published in 2022 at "Critical Reviews in Biotechnology"
DOI: 10.1080/07388551.2022.2036691
Abstract: Abstract Appropriate treatment of Hemophilia B is vital for patients’ quality of life. Historically, the treatment used was the administration of coagulation Factor IX derived from human plasma. Advancements in recombinant technologies allowed Factor IX… read more here.
Keywords: recombinant factor; bioprocessing cell; factor; production ... See more keywords
New cell engineering approaches for cartilage regenerative medicine.
Sign Up to like & getrecommendations! Published in 2017 at "Bio-medical materials and engineering"
DOI: 10.3233/bme-171642
Abstract: Articular cartilage injuries have an inadequate aptitude to reproduce the original structure and functions of this highly specialized tissue. As most of the currently available options also do not lead to the restoration of the… read more here.
Keywords: medicine; engineering; cell engineering; engineering approaches ... See more keywords
Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.943310
Abstract: Neuronal networks in dissociated culture combined with cell engineering technology offer a pivotal platform to constructively explore the relationship between structure and function in living neuronal networks. Here, we fabricated defined neuronal networks possessing a… read more here.
Keywords: neuronal networks; cell engineering; structure function;