Tumor cell enrichment by tissue suspension enables detection of mutations with low variant allele frequency and estimation of germline mutations
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-06885-2
Abstract: Targeted sequencing offers an opportunity to select specific drugs for cancer patients based on alterations in their genome. However, accurate sequencing cannot be performed in cancers harboring diffuse tumor cells because of low tumor content.… read more here.
Keywords: tumor; tissue suspension; tumor cell; cell enrichment ... See more keywords
Mesenchymal Epithelial Transition Factor Signaling in Pediatric Nervous System Tumors: Implications for Malignancy and Cancer Stem Cell Enrichment
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.654103
Abstract: Malignant nervous system cancers in children are the most devastating and worrisome diseases, specifically due to their aggressive nature and, in some cases, inoperable location in critical regions of the brain and spinal cord, and… read more here.
Keywords: cell enrichment; system; nervous system; malignancy ... See more keywords
Association of Suppressive Myeloid Cell Enrichment with Aggressive Oropharynx Squamous Cell Carcinoma
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DOI: 10.3390/cancers15082346
Abstract: Simple Summary Human papillomavirus positive (HPV+) ororpharyngeal squamous cell carcinoma (OPSCC) patients have improved clinical prognosis, compared to HPV-negative OPSCC patients. While HPV+ OPSCC patients often have more immune-cell-infiltrated tumors, they can be subjected to… read more here.
Keywords: hpv negative; cell; opscc; squamous cell ... See more keywords