The role of lipid rafts in cell entry of human metapneumovirus
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25414
Abstract: Human metapneumovirus (hMPV) is a crucial pathogen in children. A cell entry is the first step for infection. Our previous study indicated that there was an endocytosis pathway for hMPV cell entry. Lipid raft is… read more here.
Keywords: hmpv; role; cell entry; entry ... See more keywords
Integrin beta and receptor for activated protein kinase C are involved in the cell entry of Bombyx mori cypovirus
Sign Up to like & getrecommendations! Published in 2017 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-017-8158-z
Abstract: Receptor-mediated endocytosis using a β1 integrin-dependent internalization was considered as the primary mechanism for the initiation of mammalian reovirus infection. Bombyx mori cypovirus (BmCPV) is a member of Reoviridae family which mainly infects the midgut… read more here.
Keywords: rack1; cell entry; bmcpv; receptor ... See more keywords
ACE2: The Major Cell Entry Receptor for SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Lung"
DOI: 10.1007/s00408-020-00408-4
Abstract: Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus has infected more than 46 million people worldwide, killing over one million two hundred thousand. Understanding the mechanisms by which some individuals are… read more here.
Keywords: sars cov; cov ace2; receptor sars; cell entry ... See more keywords
Host Manipulation Mechanisms of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Acta Biotheoretica"
DOI: 10.1007/s10441-021-09425-z
Abstract: Viruses are the simplest of pathogens, but possess sophisticated molecular mechanisms to manipulate host behavior, frequently utilizing molecular mimicry. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been shown to bind to the host receptor… read more here.
Keywords: binding neuropilin; host; sars cov; cell entry ... See more keywords
The Orchestra of Reovirus Cell Entry
Sign Up to like & getrecommendations! Published in 2017 at "Current Clinical Microbiology Reports"
DOI: 10.1007/s40588-017-0067-5
Abstract: Purpose of ReviewThe ability of viruses to infect host cells is dependent on several factors including the availability of cell-surface receptors, antiviral state of cells, and presence of host factors needed for viral replication. Here,… read more here.
Keywords: reovirus cell; cell; cell entry; host ... See more keywords
How tetraspanin-mediated cell entry of SARS-CoV-2 can dysregulate the shedding of the ACE2 receptor by ADAM17
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2022.01.038
Abstract: COVID-19, the respiratory infection caused by the novel coronavirus SARS-CoV-2, presents a clinical picture consistent with the dysregulation of many of the pathways mediated by the metalloprotease ADAM17. ADAM17 is a sheddase that plays a… read more here.
Keywords: sars cov; adam17; cell entry; ace2 receptor ... See more keywords
Targeted in situ self-assembly augments peptide drug conjugate cell-entry efficiency.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.121139
Abstract: Peptide drug conjugate (PDC) has emerged as one of the new generations of targeted therapeutics for cancer, which owns the advantages of improved drug targetability and reduced adverse effects compared with traditional chemotherapy. However, the… read more here.
Keywords: peptide drug; drug; pdc; drug conjugate ... See more keywords
Dissipative particle dynamics simulation of cell entry into a micro-channel
Sign Up to like & getrecommendations! Published in 2019 at "Engineering Analysis with Boundary Elements"
DOI: 10.1016/j.enganabound.2019.07.004
Abstract: Abstract Cell deformability is an important biomarker which can be used to distinguish and sort between healthy and cancer cells. In this paper, we presented a dissipative particle dynamics (DPD) model for investigating cell entry… read more here.
Keywords: entry micro; particle dynamics; dissipative particle; cell entry ... See more keywords
Graph Convolutional Network-Based Screening Strategy for Rapid Identification of SARS-CoV-2 Cell-Entry Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c00222
Abstract: The cell entry of SARS-CoV-2 has emerged as an attractive drug development target. We previously reported that the entry of SARS-CoV-2 depends on the cell surface heparan sulfate proteoglycan (HSPG) and the cortex actin, which… read more here.
Keywords: graph convolutional; cell; cell entry; identification ... See more keywords
Effect of Conformational Variability on Seasonable Thermal Stability and Cell Entry of Omicron Variants
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c08075
Abstract: The Omicron BA.1 variant of SARS-CoV-2 preferentially infects through the cathepsin-mediated endocytic pathway, but the mechanism of cell entry has not been solved yet because BA.4/5 is more fusogenic and more efficiently spread in human… read more here.
Keywords: cell entry; omicron; conformational variability;
Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.00093-23
Abstract: Adeno-associated viruses (AAVs) are a proven recombinant vector platform for gene therapy and have demonstrated success in the clinic. Continuing to improve our knowledge of AAV-host cell interactions is critical for improving the safety and… read more here.
Keywords: cell; furin; cell entry; adeno associated ... See more keywords