A Newly Identified Spike Protein Targeted Linear B-Cell Epitope Based Dissolvable Microneedle Array Successfully Eliciting Neutralizing Activities against SARS-CoV-2 Wild-Type Strain in Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202207474
Abstract: Vaccination is a cost-effective medical intervention. Inactivated whole virusor large protein fragments-based severe acute respiratory syndrome coronavirus (SARS-CoV-2) vaccines have high unnecessary antigenic load to induce allergenicity and/orreactogenicity, which can be avoided by peptide vaccines… read more here.
Keywords: cell epitope; linear cell; cov wild; sars cov ... See more keywords
T-Cell Epitope Immunotherapy in Mouse Models of Food Allergy.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1001-5_21
Abstract: Food allergy has been rising in prevalence over the last two decades, affecting more than 10% of the world population. Current management of IgE-mediated food allergy relies on avoidance and rescue medications; research into treatments… read more here.
Keywords: food allergy; models food; food; cell epitope ... See more keywords
On the feasibility of mining CD8+ T cell receptor patterns underlying immunogenic peptide recognition
Sign Up to like & getrecommendations! Published in 2017 at "Immunogenetics"
DOI: 10.1007/s00251-017-1023-5
Abstract: Current T cell epitope prediction tools are a valuable resource in designing targeted immunogenicity experiments. They typically focus on, and are able to, accurately predict peptide binding and presentation by major histocompatibility complex (MHC) molecules… read more here.
Keywords: peptide; recognition; cell receptor; cell ... See more keywords
Identification of a potent regulatory T cell epitope in factor V that modulates CD4+ and CD8+ memory T cell responses.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical immunology"
DOI: 10.1016/j.clim.2020.108661
Abstract: Identification of T cell epitopes that are recognized by Tregs may elucidate the relative contributions of thymic Tregs and induced Tregs to control of autoimmune diseases and allergy. One such T regulatory cell epitope or… read more here.
Keywords: regulatory cell; tregitope; identification; cell ... See more keywords
Computational design of SARS-CoV-2 spike glycoproteins to increase immunogenicity by T cell epitope engineering
Sign Up to like & getrecommendations! Published in 2020 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2020.12.039
Abstract: The development of effective and safe vaccines is the ultimate way to efficiently stop the ongoing COVID-19 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Built on the fact that SARS-CoV-2… read more here.
Keywords: protein; immunogenicity; spike; sars cov ... See more keywords
Immunogenicity of synthetic peptide constructs based on PvMSP9E795-A808, a linear B-cell epitope of the P. vivax Merozoite Surface Protein-9.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.10.016
Abstract: Plasmodium vivax Merozoite Surface Protein-9 (PvMSP-9) is a malaria vaccine candidate naturally immunogenic in humans and able to induce high antibody titers in animals when delivered as a recombinant protein. Recently, we identified the sequence… read more here.
Keywords: protein; merozoite surface; vivax merozoite; pvmsp9e795 a808 ... See more keywords
Immuno-informatics approach for B-cell and T-cell epitope based peptide vaccine design against novel COVID-19 virus
Sign Up to like & getrecommendations! Published in 2021 at "Vaccine"
DOI: 10.1016/j.vaccine.2021.01.011
Abstract: COVID-19 has brought the world to a standstill with a wave of destruction in country after country with tremendous loss of lives and livelihood in advanced to developing nations. Whole world is staring at the… read more here.
Keywords: cell; covid; epitope based; cell cell ... See more keywords
Human B Cell Epitope Map of the Lyme Disease Vaccine Antigen, OspA.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00346
Abstract: The Lyme disease (LD) vaccine formerly approved for use in the United States consisted of recombinant outer surface protein A (OspA) from Borrelia burgdorferi sensu stricto (ss), the bacterial genospecies responsible for the vast majority… read more here.
Keywords: epitope; lyme disease; epitope map; ospa ... See more keywords
Structural Basis for CD4+ T Cell Epitope Dominance in Arbo-Flavivirus Envelope Proteins: A Meta-Analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Viral immunology"
DOI: 10.1089/vim.2017.0008
Abstract: A meta-analysis of CD4+ T cell epitope maps reveals clusters and gaps in envelope-protein (E protein) immunogenicity that can be explained by the likelihood of epitope processing, as determined by E protein three-dimensional structures. Differential… read more here.
Keywords: cd4 cell; epitope; cell epitope; meta analysis ... See more keywords
FVIII proteins with a modified immunodominant T-cell epitope exhibit reduced immunogenicity and normal FVIII activity.
Sign Up to like & getrecommendations! Published in 2018 at "Blood advances"
DOI: 10.1182/bloodadvances.2017013482
Abstract: Factor VIII (FVIII)-neutralizing antibodies (inhibitors) are a serious complication in hemophilia A (HA). The peptide FVIII2194-2213 contains an immunodominant HLA-DRA*01-DRB1*01:01 (DRB1*01:01)-restricted epitope recognized by CD4+ T-effector cells from HA subjects. The aim of this study… read more here.
Keywords: immunogenicity; fviii; fviii proteins; cell ... See more keywords
Diversity and evolution of computationally predicted T cell epitopes against human respiratory syncytial virus
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1010360
Abstract: Human respiratory syncytial virus (RSV) is a major cause of lower respiratory infection. Despite more than 60 years of research, there is no licensed vaccine. While B cell response is a major focus for vaccine… read more here.
Keywords: cell; cell epitope; rsv; respiratory ... See more keywords