A Nanotherapeutic Strategy to Reverse NK Cell Exhaustion.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202211370
Abstract: As a specialized immune effector cell, natural killer (NK) cells play a very important role in immunotherapy, but tumor immunosuppression caused by abnormal expression of cancer cells seriously weakens its therapeutic effect and leads to… read more here.
Keywords: cell; reverse cell; exhaustion; cell exhaustion ... See more keywords
Human CD96 Correlates to Natural Killer Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30347
Abstract: Immune checkpoint blockade has become a promising therapeutic approach to reverse immune cell exhaustion. Coinhibitory CD96 and T‐cell immunoglobulin and ITIM domain (TIGIT), together with costimulatory CD226, bind to common ligand CD155. The balancing between… read more here.
Keywords: expression; human hepatocellular; cd96; cell exhaustion ... See more keywords
T cell exhaustion in cancer: Mechanisms and clinical implications
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26645
Abstract: During chronic viral infection or cancer, the immune system usually induces a corresponding immune response against pathogens or cancer cells so as to prevent worsening disease. T cell exhaustion in which reduced and dysfunctional effector… read more here.
Keywords: cancer; exhaustion cancer; cancer mechanisms; cell exhaustion ... See more keywords
γδ T cell exhaustion: Opportunities for intervention
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5mr0722-777r
Abstract: T lymphocytes are the key protective contributors in chronic infection and tumor, but experience exhaustion by persistent antigen stimulation. As an unconventional lineage of T cells, γδ T cells can rapidly response to varied infectious… read more here.
Keywords: exhaustion opportunities; exhaustion; opportunities intervention; cell exhaustion ... See more keywords
T cell exhaustion characterized by compromised MHC class I and II restricted cytotoxic activity associates with acute B lymphoblastic leukemia relapse after allogeneic hematopoietic stem cell transplantation.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical immunology"
DOI: 10.1016/j.clim.2018.02.009
Abstract: Acute B lymphoblastic leukemia (B-ALL) relapse contributes predominantly to the mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the mechanism of B-ALL relapse after allo-HSCT remains unknown. The eradication of leukemia after allo-HSCT largely… read more here.
Keywords: allo hsct; cell; relapse; leukemia ... See more keywords
Strategies to overcome HBV-specific T cell exhaustion: checkpoint inhibitors and metabolic re-programming.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2018.01.003
Abstract: HBV-specific T cells play a key role in antiviral protection and failure to control HBV is associated with severely dysfunctional T cell responses. Therefore, functional T cell reconstitution represents a potential way to treat chronically… read more here.
Keywords: hbv; checkpoint; hbv specific; cell ... See more keywords
T cell exhaustion implications during transplantation.
Sign Up to like & getrecommendations! Published in 2018 at "Immunology letters"
DOI: 10.1016/j.imlet.2018.08.003
Abstract: Exhaustion of lymphocyte function, particularly T cell exhaustion, due to prolonged exposure to a high load of foreign antigen is commonly seen during chronic viral infection as well as antitumor immune responses. This phenomenon has… read more here.
Keywords: exhaustion implications; exhaustion; implications transplantation; cell exhaustion ... See more keywords
The role of polyspecific T-cell exhaustion in severe outcomes for COVID-19 patients having latent pathogen infections such as Toxoplasmagondii
Sign Up to like & getrecommendations! Published in 2021 at "Microbial Pathogenesis"
DOI: 10.1016/j.micpath.2021.105299
Abstract: Various categories of coronavirus disease 19 (COVID-19) patients have exhibited major mortality rate differences and symptoms. Some papers have recently explained these differences in mortality rates and symptoms as a consequence of this virus infection… read more here.
Keywords: covid patients; pathogen infections; cell; cell exhaustion ... See more keywords
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
Sign Up to like & getrecommendations! Published in 2021 at "Nature immunology"
DOI: 10.1038/s41590-020-00834-9
Abstract: Cancer and chronic infections induce T cell exhaustion, a hypofunctional fate carrying distinct epigenetic, transcriptomic and metabolic characteristics. However, drivers of exhaustion remain poorly understood. As intratumoral exhausted T cells experience severe hypoxia, we hypothesized… read more here.
Keywords: cell; hypoxia; continuous stimulation; exhaustion ... See more keywords
MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2106083119
Abstract: Significance CD8 T cell exhaustion is a key underlying factor limiting immunity in chronic infections and cancer. Persistent antigen exposure antagonizes formation of functional memory CD8 T cells that provide long-term protection and, instead, drives… read more here.
Keywords: cell exhaustion; cd8 cells; cd8 cell; cd8 ... See more keywords
Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2021.1937123
Abstract: ABSTRACT Introduction:T cell functions are altered during chronic viral infections and tumor development. This is mainly manifested by significant changes in T cells’ epigenetic and metabolic landscapes, pushing them into an ‘exhausted’ state. Reversing this… read more here.
Keywords: cell; review; reversing cell; exhaustion ... See more keywords