Atypical lymphocytosis due to CD8‐positive T‐cell expansion in unsuspected HIV infection
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26318
Abstract: Atypical lymphocytosis due to CD8-positive T-cell expansion in unsuspected HIV infection Katrina Parsons | Yezenash Ayalew | Celia Jackson | Mike Leach | Barbara J. Bain Beatson West of Scotland Cancer Centre, Glasgow, UK West… read more here.
Keywords: due cd8; cell expansion; positive cell; lymphocytosis due ... See more keywords
Design of cell expansion processes for adherent‐growing cells with mDoE‐workflow
Sign Up to like & getrecommendations! Published in 2023 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.202200059
Abstract: Adherent cells, mammalian or human, are ubiquitous for production of viral vaccines, in gene therapy and in immuno‐oncology. The development of a cell‐expansion process with adherent cells is challenging as scale‐up requires the expansion of… read more here.
Keywords: cell; mdoe workflow; development; cell expansion ... See more keywords
Optimizing T Cell Expansion in a Hollow-Fiber Bioreactor
Sign Up to like & getrecommendations! Published in 2018 at "Current Stem Cell Reports"
DOI: 10.1007/s40778-018-0116-x
Abstract: Purpose of ReviewRecent developments in regenerative medicine have precipitated the need to expand gene-modified human T cells to numbers that exceed the capacity of well-plate-based, and flask-based processes. This review discusses the changes in process… read more here.
Keywords: bioreactor; hollow fiber; cell; cell expansion ... See more keywords
Development of a Sensitive and Efficient Reporter Platform for the Detection of Chimeric Antigen Receptor T Cell Expansion, Trafficking, and Toxicity
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.450
Abstract: Introduction Despite the success of chimeric antigen receptor T (CART) cell therapy, it is limited by lower rates of durable responses related to inadequate CART cell expansion and trafficking and life-threatening complications such as cytokine… read more here.
Keywords: cart; expansion trafficking; cart cells; cell expansion ... See more keywords
PGE2 ameliorated viral myocarditis development and promoted IL-10-producing regulatory B cell expansion via MAPKs/AKT-AP1 axis or AhR signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2019.104025
Abstract: B10 cells, a specific subset of regulatory B cells, are capable of regulating immune response and restricting inflammation and autoimmune disease progression by producing IL-10. B10 cells frequently change significantly during inflammation and autoimmunity. However,… read more here.
Keywords: cell expansion; pge2; b10; cell ... See more keywords
CRL4DCAF2 is required for mature T-cell expansion via Aurora B-regulated proteasome activity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2018.08.006
Abstract: The proliferation of T cells in peripheral lymphoid tissues requires T cell receptor (TCR)-mediated cell cycle entry. However, the underlying mechanism regulating cell cycle progression in mature T cells is incompletely understood. Here, we have… read more here.
Keywords: mature; cell expansion; crl4dcaf2; proteasome activity ... See more keywords
IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2018.06.008
Abstract: Background & Aims Crohn’s disease is an inflammatory bowel disease that affects the ileum and is associated with increased cytokines. Although interleukin (IL)6, IL17, IL21, and IL22 are increased in Crohn’s disease and are associated… read more here.
Keywords: cell expansion; expansion; ileal organoid; il22 ... See more keywords
Optimization of a phenol red-free T cell expansion medium to improve performance and workflow flexibility
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.04.047
Abstract: Background & Aim Adoptive immunotherapy displays immense potential as an immunotherapeutic strategy for patients with advanced malignancies. Phenol red has been a mainstay in media used for the ex vivo expansion of primary T cells.… read more here.
Keywords: phenol red; phenol; cell expansion; medium ... See more keywords
Seeding density is critical for optimizing scalable feeder-free natural killer cell expansion
Sign Up to like & getrecommendations! Published in 2020 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2020.03.240
Abstract: Background & Aim Generating clinical doses of natural killer (NK) cells is an important challenge for Chimeric Antigen Receptor (CAR)-NK cell therapies. Current manufacturing methods to expand NK cells include irradiated feeder cells. However, these… read more here.
Keywords: cell expansion; expansion; seeding density; purity ... See more keywords
SAUR proteins and PP2C.D phosphatases regulate H+-ATPases and K+ channels to control stomatal movements.
Sign Up to like & getrecommendations! Published in 2021 at "Plant physiology"
DOI: 10.1093/plphys/kiaa023
Abstract: Activation of plasma membrane (PM) H+-ATPase activity is crucial in guard cells to promote light-stimulated stomatal opening, and in growing organs to promote cell expansion. In growing organs, SMALL AUXIN UP RNA (SAUR) proteins inhibit… read more here.
Keywords: stomatal movements; saur proteins; cell expansion; pp2c phosphatases ... See more keywords
Rice STOMATAL CYTOKINESIS DEFECTIVE2 regulates cell expansion by affecting vesicular trafficking in rice
Sign Up to like & getrecommendations! Published in 2022 at "Plant Physiology"
DOI: 10.1093/plphys/kiac073
Abstract: Abstract Vesicular trafficking plays critical roles in cell expansion in yeast and mammals, but information linking vesicular trafficking and cell expansion in plants is limited. Here, we isolated and characterized a rice (Oryza sativa) mutant,… read more here.
Keywords: rice; vesicular trafficking; cell expansion; plant ... See more keywords