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   Articles with "cell expansion" as a keyword



Atypical lymphocytosis due to CD8‐positive T‐cell expansion in unsuspected HIV infection

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recommendations! Published in 2021 at "American Journal of Hematology"

DOI: 10.1002/ajh.26318

Abstract: Atypical lymphocytosis due to CD8-positive T-cell expansion in unsuspected HIV infection Katrina Parsons | Yezenash Ayalew | Celia Jackson | Mike Leach | Barbara J. Bain Beatson West of Scotland Cancer Centre, Glasgow, UK West… read more here.

Keywords: due cd8; cell expansion; positive cell; lymphocytosis due ... See more keywords

Design of cell expansion processes for adherent‐growing cells with mDoE‐workflow

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recommendations! Published in 2023 at "Engineering in Life Sciences"

DOI: 10.1002/elsc.202200059

Abstract: Adherent cells, mammalian or human, are ubiquitous for production of viral vaccines, in gene therapy and in immuno‐oncology. The development of a cell‐expansion process with adherent cells is challenging as scale‐up requires the expansion of… read more here.

Keywords: cell; mdoe workflow; development; cell expansion ... See more keywords

Optimizing T Cell Expansion in a Hollow-Fiber Bioreactor

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recommendations! Published in 2018 at "Current Stem Cell Reports"

DOI: 10.1007/s40778-018-0116-x

Abstract: Purpose of ReviewRecent developments in regenerative medicine have precipitated the need to expand gene-modified human T cells to numbers that exceed the capacity of well-plate-based, and flask-based processes. This review discusses the changes in process… read more here.

Keywords: bioreactor; hollow fiber; cell; cell expansion ... See more keywords
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Development of a Sensitive and Efficient Reporter Platform for the Detection of Chimeric Antigen Receptor T Cell Expansion, Trafficking, and Toxicity

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recommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"

DOI: 10.1016/j.bbmt.2019.12.450

Abstract: Introduction Despite the success of chimeric antigen receptor T (CART) cell therapy, it is limited by lower rates of durable responses related to inadequate CART cell expansion and trafficking and life-threatening complications such as cytokine… read more here.

Keywords: cart; expansion trafficking; cart cells; cell expansion ... See more keywords

PGE2 ameliorated viral myocarditis development and promoted IL-10-producing regulatory B cell expansion via MAPKs/AKT-AP1 axis or AhR signaling.

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recommendations! Published in 2019 at "Cellular immunology"

DOI: 10.1016/j.cellimm.2019.104025

Abstract: B10 cells, a specific subset of regulatory B cells, are capable of regulating immune response and restricting inflammation and autoimmune disease progression by producing IL-10. B10 cells frequently change significantly during inflammation and autoimmunity. However,… read more here.

Keywords: cell expansion; pge2; b10; cell ... See more keywords

CRL4DCAF2 is required for mature T-cell expansion via Aurora B-regulated proteasome activity.

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recommendations! Published in 2019 at "Journal of autoimmunity"

DOI: 10.1016/j.jaut.2018.08.006

Abstract: The proliferation of T cells in peripheral lymphoid tissues requires T cell receptor (TCR)-mediated cell cycle entry. However, the underlying mechanism regulating cell cycle progression in mature T cells is incompletely understood. Here, we have… read more here.

Keywords: mature; cell expansion; crl4dcaf2; proteasome activity ... See more keywords

IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model

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recommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"

DOI: 10.1016/j.jcmgh.2018.06.008

Abstract: Background & Aims Crohn’s disease is an inflammatory bowel disease that affects the ileum and is associated with increased cytokines. Although interleukin (IL)6, IL17, IL21, and IL22 are increased in Crohn’s disease and are associated… read more here.

Keywords: cell expansion; expansion; ileal organoid; il22 ... See more keywords

Optimization of a phenol red-free T cell expansion medium to improve performance and workflow flexibility

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recommendations! Published in 2019 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2019.04.047

Abstract: Background & Aim Adoptive immunotherapy displays immense potential as an immunotherapeutic strategy for patients with advanced malignancies. Phenol red has been a mainstay in media used for the ex vivo expansion of primary T cells.… read more here.

Keywords: phenol red; phenol; cell expansion; medium ... See more keywords
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Seeding density is critical for optimizing scalable feeder-free natural killer cell expansion

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recommendations! Published in 2020 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2020.03.240

Abstract: Background & Aim Generating clinical doses of natural killer (NK) cells is an important challenge for Chimeric Antigen Receptor (CAR)-NK cell therapies. Current manufacturing methods to expand NK cells include irradiated feeder cells. However, these… read more here.

Keywords: cell expansion; expansion; seeding density; purity ... See more keywords

A critical role of N4-acetylation of cytidine in mRNA by NAT10 in T cell expansion and antiviral immunity

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recommendations! Published in 2025 at "Nature Immunology"

DOI: 10.1038/s41590-025-02100-2

Abstract: Following activation, naive T cells exit quiescence and require global translation for rapid expansion, yet the underlying mechanisms remain unclear. Here, we show that during T cell activation, cells upregulate the expression of N-acetyltransferase 10… read more here.

Keywords: critical role; mrna; cell expansion; cell ... See more keywords

The GAs–RhMYB70 feedback loop fine-tunes cell expansion and petal size by modulating cellulose content in rose

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recommendations! Published in 2025 at "Horticulture Research"

DOI: 10.1093/hr/uhaf134

Abstract: Abstract Cell expansion in petals plays a crucial role in flower opening and final size in rose (Rosa hybrida), which largely determines its market value. While cell expansion is known to be closely associated with… read more here.

Keywords: size; cellulose content; cell expansion; petal size ... See more keywords