Epigenetic age reversal by cell-extrinsic and cell-intrinsic means.
Sign Up to like & getrecommendations! Published in 2019 at "Rejuvenation research"
DOI: 10.1089/rej.2019.2271
Abstract: Reversal of aging by factors or drugs that reprogram adult cells to induce pluripotent stem cells (iPSC) suggests that at least at the cellular level aging may be reversible by resetting somatic cell state to… read more here.
Keywords: dnama; reversal; cell extrinsic; age ... See more keywords
Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment
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DOI: 10.1128/mcb.00603-17
Abstract: Zinc finger protein 521 (ZFP521), a DNA-binding protein containing 30 Krüppel-like zinc fingers, has been implicated in the differentiation of multiple cell types, including hematopoietic stem and progenitor cells (HSPC) and B lymphocytes. Here, we… read more here.
Keywords: cell extrinsic; zinc; zinc finger; protein 521 ... See more keywords
Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02206
Abstract: In response to infection with intracellular microorganisms, old mice mobilize decreased numbers of antigen-specific CD8 T cells with reduced expression of effector molecules and impaired cytolytic activity. Molecular mechanisms behind these defects and the cell-intrinsic… read more here.
Keywords: cell extrinsic; cd8; cd8 cells; aged mice ... See more keywords
Neuronal Polarity Pathways as Central Integrators of Cell-Extrinsic Information During Interactions of Neural Progenitors With Germinal Niches
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.829666
Abstract: Germinal niche interactions and their effect on developing neurons have become the subject of intense investigation. Dissecting the complex interplay of cell-extrinsic and cell-intrinsic factors at the heart of these interactions reveals the critical basic… read more here.
Keywords: cell; polarity pathways; cell extrinsic; neuronal polarity ... See more keywords