CELL FACTORY ENGINEERING: CHALLENGES AND OPPORTUNITIES FOR SYNTHETIC BIOLOGY APPLICATIONS.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28365
Abstract: The production of high-quality recombinant proteins is critical to maintaining a continuous supply of biopharmaceuticals, such as therapeutic antibodies. Engineering mammalian cell factories presents a number of limitations typically associated with the proteotoxic stress induced… read more here.
Keywords: cell factory; factory engineering; engineering; biology ... See more keywords
Cell Factory Design and Optimization for the Stereoselective Synthesis of Polyhydroxylated Compounds
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201700464
Abstract: A synthetic cascade for the transformation of primary alcohols into polyhydroxylated compounds in Escherichia coli, through the in situ preparation of cytotoxic aldehyde intermediates and subsequent aldolase‐mediated C−C bond formation, has been investigated. An enzymatic… read more here.
Keywords: factory design; design optimization; polyhydroxylated compounds; optimization stereoselective ... See more keywords
Producing a glycosylating Escherichia coli cell factory: The placement of the bacterial oligosaccharyl transferase pglB onto the genome.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.023
Abstract: Although Escherichia coli has been engineered to perform N-glycosylation of recombinant proteins, an optimal glycosylating strain has not been created. By inserting a codon optimised Campylobacter oligosaccharyltransferase onto the E. coli chromosome, we created a glycoprotein… read more here.
Keywords: glycosylating escherichia; escherichia coli; cell factory; glycoprotein ... See more keywords
Enzymatic and cell factory approaches to the production of human milk oligosaccharides.
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2019.03.014
Abstract: Infant formula milk companies try to develop fortified formula milk that mimics human milk as closely as possible, since it is well-known that breast milk has considerable implications in the development of the infant in… read more here.
Keywords: milk; production; cell factory; human milk ... See more keywords
Cell factory models of non-engineered S. cerevisiae containing lactase in a second layer for lactose fermentation in one batch.
Sign Up to like & getrecommendations! Published in 2021 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2021.109750
Abstract: The objective of this project was to ferment lactose and whey to ethanol in one-step process. Models of cell factory of non-engineered S.cerevisiae have been proposed to ferment lactose. The cell factory of non-engineered S.… read more here.
Keywords: non engineered; factory; engineered cerevisiae; fermentation ... See more keywords
Establishing Komagataella phaffii as a Cell Factory for Efficient Production of Sesquiterpenoid α-Santalene.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02353
Abstract: Santalene, a major component of the sandalwood essential oil, is a typical representative of sesquiterpenes and has important applications in medicine, food, flavors, and other fields. Due to the limited supply of natural sandalwood resources,… read more here.
Keywords: cell factory; komagataella phaffii; santalene; production ... See more keywords
Development and Perspective of Rhodotorula toruloides as an Efficient Cell Factory.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c07361
Abstract: Rhodotorula toruloides is receiving significant attention as a novel cell factory because of its high production of lipids and carotenoids, fast growth and high cell density, as well as the ability to utilize a wide… read more here.
Keywords: cell factory; cell; engineering; rhodotorula toruloides ... See more keywords
Corynebacterium Cell Factory Design and Culture Process Optimization for Muconic Acid Biosynthesis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-36320-4
Abstract: Muconic acid (MA) is a valuable compound for adipic acid production, which is a precursor for the synthesis of various polymers such as plastics, coatings, and nylons. Although MA biosynthesis has been previously reported in… read more here.
Keywords: biosynthesis; corynebacterium; cell factory; muconic acid ... See more keywords
Characteristics and Application of Rhodopseudomonas palustris as a Microbial Cell Factory
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.897003
Abstract: Rhodopseudomonas palustris, a purple nonsulfur bacterium, is a bacterium with the properties of extraordinary metabolic versatility, carbon source diversity and metabolite diversity. Due to its biodetoxification and biodegradation properties, R. palustris has been traditionally applied… read more here.
Keywords: cell factory; rhodopseudomonas palustris; microbial cell; application ... See more keywords
Cell Factory Engineering of Undomesticated Bacillus Strains Using a Modified Integrative and Conjugative Element for Efficient Plasmid Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.802040
Abstract: A large number of Bacillus strains have been isolated from various environments and many of them have great potential as cell factories. However, they have been rarely developed as cell factories due to their poor… read more here.
Keywords: cell factory; cell; bacillus; bacillus strains ... See more keywords
Engineered Escherichia coli cell factory for anthranilate over-production
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1081221
Abstract: Anthranilate is a key platform chemical in high demand for synthesizing food ingredients, dyes, perfumes, crop protection compounds, pharmaceuticals, and plastics. Microbial-based anthranilate production strategies have been developed to overcome the unstable and expensive supply… read more here.
Keywords: cell factory; escherichia coli; production; anthranilate production ... See more keywords