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Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11170-4
Abstract: Compromised function of insulin-secreting pancreatic β cells is central to the development and progression of Type 2 Diabetes (T2D). However, the mechanisms underlying β cell failure remain incompletely understood. Here, we report that metabolic stress…
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Keywords:
insulin;
degradation;
lysosomal degradation;
cell failure ... See more keywords
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Published in 2022 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13833
Abstract: Pathologically, type 2 diabetes mellitus develops on the basis of insufficient insulin action. Insulin action insufficiency results from impaired insulin secretion and/or insulin resistance, i.e., the failure of insulin to exert sufficient effects. Impairment of…
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Keywords:
cell;
cell failure;
identification islet;
type diabetes ... See more keywords
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1
Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0258054
Abstract: Progressive loss of pancreatic β-cell functional mass and anti-diabetic drug responsivity are classic findings in diabetes, frequently attributed to compensatory insulin hypersecretion and β-cell exhaustion. However, loss of β-cell mass and identity still occurs in…
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Keywords:
sglt2 inhibitors;
oxidative stress;
loss;
cell ... See more keywords
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Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.881256
Abstract: As mitochondrial metabolism is a major determinant of β-cell insulin secretion, mitochondrial dysfunction underlies β-cell failure and type 2 diabetes mellitus progression. An algal polysaccharide of Laminaria japonica, sulfated fucogalactan (SFG) displays various pharmacological effects…
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Keywords:
cell failure;
failure;
mitochondrial dysfunction;
sirt1 pgc1 ... See more keywords
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1
Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10040818
Abstract: Various important transcription factors in the pancreas are involved in the process of pancreas development, the differentiation of endocrine progenitor cells into mature insulin-producing pancreatic β-cells and the preservation of mature β-cell function. However, when…
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Keywords:
cell;
cell failure;
pancreatic cell;
type diabetes ... See more keywords
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1
Published in 2022 at "eLife"
DOI: 10.7554/elife.75132
Abstract: The mammalian circadian clock drives daily oscillations in physiology and behavior through an autoregulatory transcription feedback loop present in central and peripheral cells. Ablation of the core clock within the endocrine pancreas of adult animals…
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Keywords:
small molecule;
cell;
cell failure;
circadian cell ... See more keywords