Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11170-4
Abstract: Compromised function of insulin-secreting pancreatic β cells is central to the development and progression of Type 2 Diabetes (T2D). However, the mechanisms underlying β cell failure remain incompletely understood. Here, we report that metabolic stress… read more here.
Keywords: insulin; degradation; lysosomal degradation; cell failure ... See more keywords
Pancreatic β-cell failure, clinical implications, and therapeutic strategies in type 2 diabetes
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DOI: 10.1097/cm9.0000000000003034
Abstract: Abstract Pancreatic β-cell failure due to a reduction in function and mass has been defined as a primary contributor to the progression of type 2 diabetes (T2D). Reserving insulin-producing β-cells and hence restoring insulin production… read more here.
Keywords: therapeutic strategies; type diabetes; cell; cell failure ... See more keywords
Identification of islet cell characteristics in humans with type 2 diabetes by single‐cell sequencing
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13833
Abstract: Pathologically, type 2 diabetes mellitus develops on the basis of insufficient insulin action. Insulin action insufficiency results from impaired insulin secretion and/or insulin resistance, i.e., the failure of insulin to exert sufficient effects. Impairment of… read more here.
Keywords: cell; cell failure; identification islet; type diabetes ... See more keywords
SGLT2 inhibitors therapy protects glucotoxicity-induced β-cell failure in a mouse model of human KATP-induced diabetes through mitigation of oxidative and ER stress
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DOI: 10.1371/journal.pone.0258054
Abstract: Progressive loss of pancreatic β-cell functional mass and anti-diabetic drug responsivity are classic findings in diabetes, frequently attributed to compensatory insulin hypersecretion and β-cell exhaustion. However, loss of β-cell mass and identity still occurs in… read more here.
Keywords: sglt2 inhibitors; oxidative stress; loss; cell ... See more keywords
Atf4 protects islet β-cell identity and function under acute glucose-induced stress but promotes β-cell failure in the presence of free fatty acid.
Sign Up to like & getrecommendations! Published in 2025 at "Diabetes"
DOI: 10.2337/db24-0360
Abstract: Glucolipotoxicity, caused by combined hyperglycemia and hyperlipidemia, results in β-cell failure and type 2 diabetes via cellular stress-related mechanisms. Activating transcription factor 4 (Atf4) is an essential effector of stress response. We show here that… read more here.
Keywords: function; cell; cell failure; free fatty ... See more keywords
Sulfated Fucogalactan From Laminaria Japonica Ameliorates β-Cell Failure by Attenuating Mitochondrial Dysfunction via SIRT1–PGC1-α Signaling Pathway Activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.881256
Abstract: As mitochondrial metabolism is a major determinant of β-cell insulin secretion, mitochondrial dysfunction underlies β-cell failure and type 2 diabetes mellitus progression. An algal polysaccharide of Laminaria japonica, sulfated fucogalactan (SFG) displays various pharmacological effects… read more here.
Keywords: cell failure; failure; mitochondrial dysfunction; sirt1 pgc1 ... See more keywords
Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10040818
Abstract: Various important transcription factors in the pancreas are involved in the process of pancreas development, the differentiation of endocrine progenitor cells into mature insulin-producing pancreatic β-cells and the preservation of mature β-cell function. However, when… read more here.
Keywords: cell; cell failure; pancreatic cell; type diabetes ... See more keywords
P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.75132
Abstract: The mammalian circadian clock drives daily oscillations in physiology and behavior through an autoregulatory transcription feedback loop present in central and peripheral cells. Ablation of the core clock within the endocrine pancreas of adult animals… read more here.
Keywords: small molecule; cell; cell failure; circadian cell ... See more keywords