Photoactive Interfaces for Spatio-Temporal Guidance of Mesenchymal Stem Cell Fate.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202000470
Abstract: Patterned surfaces have proved effective in guiding stem cells commitment to a specific lineage by presenting highly ordered biophysical/biochemical cues at the cellmaterial interface. Their potency in controlling cell fate can be significantly empowered by… read more here.
Keywords: photoactive interfaces; lineage; cell fate; stem ... See more keywords
An Optogenetic‐Controlled Cell Reprogramming System for Driving Cell Fate and Light‐Responsive Chimeric Mice
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202858
Abstract: Pluripotent stem cells (PSCs) hold great promise for cell‐based therapies, disease modeling, and drug discovery. Classic somatic cell reprogramming to generate induced pluripotent stem cells (iPSCs) is often achieved based on overexpression of transcription factors… read more here.
Keywords: system; cell; cell fate; mice ... See more keywords
Single‐Cell Transcriptome Landscape and Cell Fate Decoding in Human Brain Organoids after Transplantation
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202402287
Abstract: Human stem cells and derivatives transplantation are widely used to treat nervous system diseases, while the fate determination of transplanted cells is not well elucidated. To explore cell fate changes of human brain organoids before… read more here.
Keywords: brain organoids; human brain; cell; cell fate ... See more keywords
When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination
Sign Up to like & getrecommendations! Published in 2025 at "Bioessays"
DOI: 10.1002/bies.70061
Abstract: Mitosis is a crucial phase of the cell cycle, during which several mechanisms work together to ensure accurate chromosome segregation and to eliminate defective cells if errors occur. One key mechanism is the spindle assembly… read more here.
Keywords: mitosis; duration; cell fate; mitotic duration ... See more keywords
Cell fate‐inducing CARs orthogonally control multiple signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202100463
Abstract: While chimeric antigen receptor (CAR) has been clinically applied in T cell‐mediated cancer therapy, CARs that combinatorially control general cell fates have yet to be practical. In this study, we aim to control multiple cell… read more here.
Keywords: cell fate; cell; fate inducing; control multiple ... See more keywords
Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Communications"
DOI: 10.1002/cac2.12520
Abstract: Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic driver mutations in combination with chemotherapy and radiotherapy as well as immunotherapy have benefited cancer patients considerably. Tumor protein p53 (TP53),… read more here.
Keywords: cancer; p53; tumor; cell fate ... See more keywords
Single cell transcriptome profiling of developing chick retinal cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24241
Abstract: The vertebrate retina is a specialized photosensitive tissue comprised of six neuronal and one glial cell types, each of which develops in prescribed proportions at overlapping timepoints from a common progenitor pool. While each of… read more here.
Keywords: single cell; developing chick; retinal cell; cell types ... See more keywords
Mitohormesis and mitochondrial dynamics in the regulation of stem cell fate
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30820
Abstract: The ability of stem cells for self‐renewing, differentiation, and regeneration of injured tissues is believed to occur via the hormetic modulation of nuclear/mitochondrial signal transductions. The evidence now indicates that in damaged tissues, the mitochondria… read more here.
Keywords: cell fate; cell; stem cell; mitochondrial dynamics ... See more keywords
Concise Review: Application of Chemically Modified mRNA in Cell Fate Conversion and Tissue Engineering
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.18-0259
Abstract: Chemically modified RNA (cmRNA) has potential as a safe and efficient tool for nucleic acid‐based therapies and regenerative medicine. Modifications in the chemistry of mRNA can enhance stability, reduce immunogenicity, and thus facilitate mRNA‐based nucleic… read more here.
Keywords: medicine; cell fate; tissue engineering; chemically modified ... See more keywords
Short Telomeres Induce p53 and Autophagy and Modulate Age‐Associated Changes in Cardiac Progenitor Cell Fate
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2793
Abstract: Aging severely limits myocardial repair and regeneration. Delineating the impact of age‐associated factors such as short telomeres is critical to enhance the regenerative potential of cardiac progenitor cells (CPCs). We hypothesized that short telomeres activate… read more here.
Keywords: cell fate; age associated; short telomeres;
Modeling ncRNA-Mediated Circuits in Cell Fate Decision.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8982-9_16
Abstract: Noncoding RNAs (ncRNAs) play critical roles in essential cell fate decisions. However, the exact molecular mechanisms underlying ncRNA-mediated bistable switches remain elusive and controversial. In recent years, systematic mathematical and quantitative experimental analyses have made… read more here.
Keywords: ncrna mediated; modeling ncrna; cell fate; biology ... See more keywords