Photoactive Interfaces for Spatio-Temporal Guidance of Mesenchymal Stem Cell Fate.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202000470
Abstract: Patterned surfaces have proved effective in guiding stem cells commitment to a specific lineage by presenting highly ordered biophysical/biochemical cues at the cellmaterial interface. Their potency in controlling cell fate can be significantly empowered by… read more here.
Keywords: photoactive interfaces; lineage; cell fate; stem ... See more keywords
An Optogenetic‐Controlled Cell Reprogramming System for Driving Cell Fate and Light‐Responsive Chimeric Mice
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202858
Abstract: Pluripotent stem cells (PSCs) hold great promise for cell‐based therapies, disease modeling, and drug discovery. Classic somatic cell reprogramming to generate induced pluripotent stem cells (iPSCs) is often achieved based on overexpression of transcription factors… read more here.
Keywords: system; cell; cell fate; mice ... See more keywords
Cell fate‐inducing CARs orthogonally control multiple signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202100463
Abstract: While chimeric antigen receptor (CAR) has been clinically applied in T cell‐mediated cancer therapy, CARs that combinatorially control general cell fates have yet to be practical. In this study, we aim to control multiple cell… read more here.
Keywords: cell fate; cell; fate inducing; control multiple ... See more keywords
Single cell transcriptome profiling of developing chick retinal cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24241
Abstract: The vertebrate retina is a specialized photosensitive tissue comprised of six neuronal and one glial cell types, each of which develops in prescribed proportions at overlapping timepoints from a common progenitor pool. While each of… read more here.
Keywords: single cell; developing chick; retinal cell; cell types ... See more keywords
Mitohormesis and mitochondrial dynamics in the regulation of stem cell fate
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30820
Abstract: The ability of stem cells for self‐renewing, differentiation, and regeneration of injured tissues is believed to occur via the hormetic modulation of nuclear/mitochondrial signal transductions. The evidence now indicates that in damaged tissues, the mitochondria… read more here.
Keywords: cell fate; cell; stem cell; mitochondrial dynamics ... See more keywords
Concise Review: Application of Chemically Modified mRNA in Cell Fate Conversion and Tissue Engineering
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.18-0259
Abstract: Chemically modified RNA (cmRNA) has potential as a safe and efficient tool for nucleic acid‐based therapies and regenerative medicine. Modifications in the chemistry of mRNA can enhance stability, reduce immunogenicity, and thus facilitate mRNA‐based nucleic… read more here.
Keywords: medicine; cell fate; tissue engineering; chemically modified ... See more keywords
Short Telomeres Induce p53 and Autophagy and Modulate Age‐Associated Changes in Cardiac Progenitor Cell Fate
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2793
Abstract: Aging severely limits myocardial repair and regeneration. Delineating the impact of age‐associated factors such as short telomeres is critical to enhance the regenerative potential of cardiac progenitor cells (CPCs). We hypothesized that short telomeres activate… read more here.
Keywords: cell fate; age associated; short telomeres;
Modeling ncRNA-Mediated Circuits in Cell Fate Decision.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8982-9_16
Abstract: Noncoding RNAs (ncRNAs) play critical roles in essential cell fate decisions. However, the exact molecular mechanisms underlying ncRNA-mediated bistable switches remain elusive and controversial. In recent years, systematic mathematical and quantitative experimental analyses have made… read more here.
Keywords: ncrna mediated; modeling ncrna; cell fate; biology ... See more keywords
Investigating Cell Fate Decisions with ICGS Analysis of Single Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9224-9_12
Abstract: Advances in single-cell transcriptome profiling have contributed to new insights into the cellular states and underlying regulatory networks that govern lineage commitment. Such cell states include multipotent progenitors that can manifest as mixed-lineage patterns of… read more here.
Keywords: single cell; investigating cell; cell states; biology ... See more keywords
Computational Analysis of Altering Cell Fate.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9224-9_17
Abstract: The notion of reprogramming cell fate is a direct challenge to the traditional view in developmental biology that a cell's phenotypic identity is sealed after undergoing differentiation. Direct experimental evidence, beginning with the somatic cell… read more here.
Keywords: computational analysis; analysis altering; cell fate; biology ... See more keywords
Computational Tools for Quantifying Concordance in Single-Cell Fate.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9224-9_6
Abstract: Cells are dynamic biological systems that interact with each other and their surrounding environment. Understanding how cell extrinsic and intrinsic factors control cell fate is fundamental to many biological experiments. However, due to transcriptional heterogeneity… read more here.
Keywords: single cell; concordance; computational tools; cell fate ... See more keywords