Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104570
Abstract: BACKGROUND Intervertebral disc degeneration (IDD) causes lower back pain, and is often accompanied with robust inflammation. However, whether inflammation plays a role in IDD remains controversial, and the mechanism is ill-elucidated. METHODS Cartilage specimens from… read more here.
Keywords: mir 10a; cell ferroptosis; cartilage cell; cartilage ... See more keywords
Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01775
Abstract: Microtubule targeting agents (MTAs) are used as clinically effective chemotherapies for cancer treatment but might be limited by the acquired or intrinsic resistance of cancer cells to apoptosis. The vulnerability of therapy-resistant cancers to ferroptosis… read more here.
Keywords: microtubule targeting; cell ferroptosis; discovery novel;
Carbon Quantum Dots-Based Nanozyme from Coffee Induces Cancer Cell Ferroptosis to Activate Antitumor Immunity.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c01619
Abstract: Carbon quantum dots (CQDs) offer huge potential due to their enzymatic properties as compared to natural enzymes. Thus, discovery of CQDs-based nanozymes with low toxicity from natural resources, especially daily food, implies a promising direction… read more here.
Keywords: coffee; quantum dots; cell ferroptosis; carbon quantum ... See more keywords
Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-022-00821-z
Abstract: Endometriosis, a chronic disorder characterised by the presence of endometrial-like tissue outside the uterus, is associated with iron overload and oxidative stress in the lesion. Although it is well established that iron overload can trigger… read more here.
Keywords: cell ferroptosis; ferroptosis; endometriosis; stromal cell ... See more keywords
Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-06848-7
Abstract: Inflammation triggers pulmonary vascular remodelling. Ferroptosis, a nonapoptotic form of cell death that is triggered by iron-dependent lipid peroxidation and contributes to the pathogenesis of several inflammation-related diseases, but its role in pulmonary hypertension (PH)… read more here.
Keywords: cell ferroptosis; ferroptosis; nlrp3 inflammasome; endothelial cell ... See more keywords
NEDD4L facilitates granulosa cell ferroptosis by promoting GPX4 ubiquitination and degradation
Sign Up to like & getrecommendations! Published in 2023 at "Endocrine Connections"
DOI: 10.1530/ec-22-0459
Abstract: Background Polycystic ovary syndrome (PCOS) is an androgen disorder and ovarian dysfunction disease in women of reproductive age. The cell death of granulosa cells (GCs) plays an important role in the development of PCOS. However,… read more here.
Keywords: cell; gpx4 ubiquitination; cell ferroptosis; ubiquitination degradation ... See more keywords
GPX4 Plays a Crucial Role in Fuzheng Kang’ai Decoction-Induced Non-Small Cell Lung Cancer Cell Ferroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.851680
Abstract: Background: Fuzheng Kang’ai decoction (FZKA) has been widely used to treat Non-Small Cell Lung Cancer (NSCLC) patients in China for decades, showing definitively curative effects in clinic. Recently, we found that FZKA could induce NSCLC… read more here.
Keywords: cell; nsclc cell; cell ferroptosis; fzka ... See more keywords
The RSL3 Induction of KLK Lung Adenocarcinoma Cell Ferroptosis by Inhibition of USP11 Activity and the NRF2-GSH Axis
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14215233
Abstract: Simple Summary High NRF2 level confers KLK LUAD cell resistance to ferroptosis. Here, we showed that the inhibition of NRF2-GSH axis sensitized a small molecule RSL3 to induce KLK LUAD cell ferroptosis in vitro. RSL3… read more here.
Keywords: klk luad; ferroptosis; cell ferroptosis;