Sparse dictionary learning recovers pleiotropy from human cell fitness screens.
Sign Up to like & getrecommendations! Published in 2022 at "Cell systems"
DOI: 10.1016/j.cels.2021.12.005
Abstract: In high-throughput functional genomic screens, each gene product is commonly assumed to exhibit a singular biological function within a defined protein complex or pathway. In practice, a single gene perturbation may induce multiple cascading functional… read more here.
Keywords: fitness screens; gene perturbation; cell fitness; fitness ... See more keywords
Regulatory molecule cAMP changes cell fitness of the engineered Escherichia coli for terpenoids production.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2020.11.009
Abstract: Terpenoids are a class of natural compounds with many important functions and applications. They are synthesized from a long synthetic pathway of isoprenyl unit coupling with the myriads of terpene synthases. Owing to the catalytic… read more here.
Keywords: escherichia coli; cell fitness; terpenoids production; production ... See more keywords
Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1101/2022.03.08.483441
Abstract: The AGR2 and AGR3 genes have been shown by numerous groups to be functionally associated to adenocarcinoma progression and metastasis. We explore in this paper the data available in databases concerning genomic and transcriptomic features… read more here.
Keywords: expression; agr2 agr3; cell fitness; integrative analysis ... See more keywords
Polarized mitochondria as guardians of NK cell fitness.
Sign Up to like & getrecommendations! Published in 2021 at "Blood advances"
DOI: 10.1182/bloodadvances.2020003458
Abstract: Distinct metabolic demands accompany lymphocyte differentiation into short-lived effector and long-lived memory cells. How bioenergetics processes are structured in innate natural killer (NK) cells remains unclear. We demonstrate that circulating human CD56Dim (NKDim) cells have… read more here.
Keywords: polarized mitochondria; cell fitness; mitochondrial polarization; guardians cell ... See more keywords