Metabolic dialogues: regulators of chimeric antigen receptor T cell function in the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13691
Abstract: Tumor‐infiltrating lymphocytes (TILs) and chimeric antigen receptor (CAR) T cells have demonstrated remarkable success in the treatment of relapsed/refractory melanoma and hematological malignancies, respectively. These treatments have marked a pivotal shift in cancer management. However,… read more here.
Keywords: chimeric antigen; antigen receptor; cell; tumor ... See more keywords
Gamma‐Glutamyl Cysteine Ligase Activity as a Proxy for Human T Cell Function and Drug‐Induced Immunosuppression
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202501179
Abstract: T cell effector functions are critical for immune defense, but their dysregulation can cause diseases like immune exhaustion in cancer and loss of tolerance in autoimmunity. Curtailing these functions is essential in therapies such as… read more here.
Keywords: gamma glutamyl; cell; glutamyl cysteine; cell function ... See more keywords
Constraints Shape Cell Function and Morphology by Canalizing the Developmental Path along the Waddington's Landscape
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.201900108
Abstract: Studies performed in absence of gravitational constraint show that a living system is unable to choose between two different phenotypes, thus leading cells to segregate into different, alternative stable states. This finding demonstrates that the… read more here.
Keywords: morphology canalizing; function morphology; cell function; shape cell ... See more keywords
Boosting Dendritic Cell Function in Cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Medicine"
DOI: 10.1002/cam4.71062
Abstract: Instruction of T cell immunity is a key function of sentinel leukocytes called dendritic cells (DC). Several studies in mice and humans have demonstrated a key role for DCs in promoting T cell responses to… read more here.
Keywords: cancer; dendritic cell; cell; boosting dendritic ... See more keywords
Adding vitamin D3 to the dipeptidyl peptidase‐4 inhibitor saxagliptin has the potential to protect β‐cell function in LADA patients: A 1‐year pilot study
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3298
Abstract: This trial was conducted to explore the protective effect on β‐cell function of adding vitamin D3 to DPP‐4 inhibitors to treat patients with latent autoimmune diabetes in adults (LADA). read more here.
Keywords: dipeptidyl peptidase; vitamin dipeptidyl; adding vitamin; cell function ... See more keywords
Dysregulation in B‐cell responses and T follicular helper cell function in ADA2 deficiency patients
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048549
Abstract: Adenosine deaminase 2 deficiency (DADA2) is an autoinflammatory disease characterized by inflammatory vasculopathy, early strokes associated often with hypogammaglobulinemia. Pure red cell aplasia, thrombocytopenia, and neutropenia have been reported. The defect is due to biallelic… read more here.
Keywords: cell responses; cell; cell function; function ada2 ... See more keywords
Associations of complete blood count parameters with pancreatic beta‐cell function and insulin resistance in prediabetes and type 2 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24454
Abstract: Previous studies found controversial associations of CBC parameters with pancreatic beta‐cell function (BCF) and insulin resistance (IR). The aim of this was to determine the independent associations of CBC parameters with BCF and IR in… read more here.
Keywords: parameters pancreatic; prediabetes type; insulin resistance; cell function ... See more keywords
Frontline Science: OX40 agonistic antibody reverses immune suppression and improves survival in sepsis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5hi0720-043r
Abstract: A defining feature of protracted sepsis is development of immunosuppression that is thought to be a major driving force in the morbidity and mortality associated with the syndrome. The immunosuppression that occurs in sepsis is… read more here.
Keywords: immunosuppression; cell function; sepsis; ox40 agonistic ... See more keywords
Effects of semaglutide on beta cell function and glycaemic control in participants with type 2 diabetes: a randomised, double-blind, placebo-controlled trial
Sign Up to like & getrecommendations! Published in 2017 at "Diabetologia"
DOI: 10.1007/s00125-017-4289-0
Abstract: Aims/hypothesisSemaglutide is a glucagon-like peptide-1 analogue in development for the treatment of type 2 diabetes. Its effects on first- and second-phase insulin secretion and other measures of beta cell function and glycaemic control were assessed.MethodsIn… read more here.
Keywords: function glycaemic; treatment; cell function; glycaemic control ... See more keywords
I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression
Sign Up to like & getrecommendations! Published in 2025 at "Diabetologia"
DOI: 10.1007/s00125-025-06541-0
Abstract: The bromodomain and extra-terminal (BET) protein family acts as ‘epigenetic readers’ to identify the acetylation marks on histones that convert the acetylated lysine residues into observable phenotypes. BET proteins have gained attention due to their… read more here.
Keywords: expression; cell function; beta cell; beta ... See more keywords
Impact of Pancreatic β-Cell Function on Clopidogrel Responsiveness and Outcomes in Chinese Nondiabetic Patients Undergoing Elective Percutaneous Coronary Intervention
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-021-07272-1
Abstract: Insulin resistance and β-cell dysfunction are fundamental defects contributing to type 2 diabetes development. Prior studies indicated that insulin resistance may be correlated with low responsiveness to clopidogrel. This study aimed to investigate the effects… read more here.
Keywords: clopidogrel; nondiabetic patients; patients undergoing; cell function ... See more keywords