Constraints Shape Cell Function and Morphology by Canalizing the Developmental Path along the Waddington's Landscape
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DOI: 10.1002/bies.201900108
Abstract: Studies performed in absence of gravitational constraint show that a living system is unable to choose between two different phenotypes, thus leading cells to segregate into different, alternative stable states. This finding demonstrates that the… read more here.
Keywords: morphology canalizing; function morphology; cell function; shape cell ... See more keywords
Adding vitamin D3 to the dipeptidyl peptidase‐4 inhibitor saxagliptin has the potential to protect β‐cell function in LADA patients: A 1‐year pilot study
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3298
Abstract: This trial was conducted to explore the protective effect on β‐cell function of adding vitamin D3 to DPP‐4 inhibitors to treat patients with latent autoimmune diabetes in adults (LADA). read more here.
Keywords: dipeptidyl peptidase; vitamin dipeptidyl; adding vitamin; cell function ... See more keywords
Dysregulation in B‐cell responses and T follicular helper cell function in ADA2 deficiency patients
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DOI: 10.1002/eji.202048549
Abstract: Adenosine deaminase 2 deficiency (DADA2) is an autoinflammatory disease characterized by inflammatory vasculopathy, early strokes associated often with hypogammaglobulinemia. Pure red cell aplasia, thrombocytopenia, and neutropenia have been reported. The defect is due to biallelic… read more here.
Keywords: cell responses; cell; cell function; function ada2 ... See more keywords
Associations of complete blood count parameters with pancreatic beta‐cell function and insulin resistance in prediabetes and type 2 diabetes mellitus
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DOI: 10.1002/jcla.24454
Abstract: Previous studies found controversial associations of CBC parameters with pancreatic beta‐cell function (BCF) and insulin resistance (IR). The aim of this was to determine the independent associations of CBC parameters with BCF and IR in… read more here.
Keywords: parameters pancreatic; prediabetes type; insulin resistance; cell function ... See more keywords
Frontline Science: OX40 agonistic antibody reverses immune suppression and improves survival in sepsis
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DOI: 10.1002/jlb.5hi0720-043r
Abstract: A defining feature of protracted sepsis is development of immunosuppression that is thought to be a major driving force in the morbidity and mortality associated with the syndrome. The immunosuppression that occurs in sepsis is… read more here.
Keywords: immunosuppression; cell function; sepsis; ox40 agonistic ... See more keywords
Effects of semaglutide on beta cell function and glycaemic control in participants with type 2 diabetes: a randomised, double-blind, placebo-controlled trial
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DOI: 10.1007/s00125-017-4289-0
Abstract: Aims/hypothesisSemaglutide is a glucagon-like peptide-1 analogue in development for the treatment of type 2 diabetes. Its effects on first- and second-phase insulin secretion and other measures of beta cell function and glycaemic control were assessed.MethodsIn… read more here.
Keywords: function glycaemic; treatment; cell function; glycaemic control ... See more keywords
Impact of Pancreatic β-Cell Function on Clopidogrel Responsiveness and Outcomes in Chinese Nondiabetic Patients Undergoing Elective Percutaneous Coronary Intervention
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DOI: 10.1007/s10557-021-07272-1
Abstract: Insulin resistance and β-cell dysfunction are fundamental defects contributing to type 2 diabetes development. Prior studies indicated that insulin resistance may be correlated with low responsiveness to clopidogrel. This study aimed to investigate the effects… read more here.
Keywords: clopidogrel; nondiabetic patients; patients undergoing; cell function ... See more keywords
SHP2 Targets ITK Downstream of PD-1 to Inhibit T Cell Function.
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DOI: 10.1007/s10753-021-01437-8
Abstract: PD-1 is a critical therapeutic target in cancer immunotherapy and antibodies blocking PD-1 are approved for multiple types of malignancies. The phosphatase SHP2 is the main effector mediating PD-1 downstream signaling and accordingly attempts have… read more here.
Keywords: downstream inhibit; itk downstream; shp2 targets; inhibit cell ... See more keywords
Plasma lipid species at type 1 diabetes onset predict residual beta-cell function after 6 months
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DOI: 10.1007/s11306-018-1456-3
Abstract: IntroductionThe identification of metabolomic dysregulation appears promising for the prediction of type 1 diabetes and may also reveal metabolic pathways leading to beta-cell destruction. Recent studies indicate that regulation of multiple phospholipids precede the presence… read more here.
Keywords: type diabetes; cell function; beta cell;
Anti-CD20 therapy ameliorates β cell function and rebalances Th17/Treg cells in NOD mice
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DOI: 10.1007/s12020-021-02965-x
Abstract: Anti-CD20 therapy delays type 1 diabetes mellitus (T1DM) progression in both nonobese diabetic (NOD) mice and new-onset patients. The mechanism is not completely defined. This study aimed to investigate the effects of anti-CD20 therapy on… read more here.
Keywords: nod mice; anti cd20; cell function; th17 treg ... See more keywords
Association of Vitamin D and Parathyroid Hormone with Insulin Sensitivity, Beta Cell Function and Gestational Diabetes in Pregnancy: A Cross-Sectional, Observational Study
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DOI: 10.1007/s13300-018-0508-z
Abstract: IntroductionVitamin D (25OHD) and parathyroid hormone (PTH) are associated with dysglycemia, and we investigated them in gestational diabetes mellitus (GDM).MethodsIn this cross-sectional, observational study, we included 75 pregnant women between 24 and 28 weeks of gestation.… read more here.
Keywords: pth; insulin; cell function; beta cell ... See more keywords