Cellular homeostatic tension and force transmission measured in human engineered tendon
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomechanics"
DOI: 10.1016/j.jbiomech.2018.07.032
Abstract: Tendons transmit contractile muscular force to bone to produce movement, and it is believed cells can generate endogenous forces on the extracellular matrix to maintain tissue homeostasis. However, little is known about the direct mechanical… read more here.
Keywords: tendon; cell generated; force; force transmission ... See more keywords
An in vitro tumorigenesis model based on live-cell-generated oxygen and nutrient gradients
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-01954-0
Abstract: The tumor microenvironment (TME) is multi-cellular, spatially heterogenous, and contains cell-generated gradients of soluble molecules. Current cell-based model systems lack this complexity or are difficult to interrogate microscopically. We present a 2D live-cell chamber that… read more here.
Keywords: tumorigenesis; live cell; model; cell generated ... See more keywords
Molecular Tension Probes to Quantify Cell-Generated Mechanical Forces
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2022.2049
Abstract: Living cells generate, sense, and respond to mechanical forces through their interaction with neighboring cells or extracellular matrix, thereby regulating diverse cellular processes such as growth, motility, differentiation, and immune responses. Dysregulation of mechanosensitive signaling… read more here.
Keywords: tension probes; generated mechanical; mechanical forces; tension ... See more keywords