Changes to culture pH and dissolved oxygen can enhance chimeric antigen receptor T‐cell generation and differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3275
Abstract: Chimeric antigen receptor (CAR) T‐cell therapy is growing clinically and commercially as a powerful new approach to treat cancer. Understanding how key culture conditions such as pH and dissolved oxygen (DO) affect CAR T‐cell generation… read more here.
Keywords: culture; cell; cell generation; car ... See more keywords
GemC1 is a critical switch for neural stem cell generation in the postnatal brain
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23690
Abstract: The subventricular zone (SVZ) is one of two main niches where neurogenesis persists during adulthood, as it retains neural stem cells (NSCs) with self‐renewal capacity and multi‐lineage potency. Another critical cellular component of the niche… read more here.
Keywords: cell generation; gemc1 critical; generation; cell ... See more keywords
RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T‐Helper‐2‐Cell‐Biased Programs
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.09.004
Abstract: &NA; Pathogenic Th17 (pTh17) cells drive inflammation and immune‐pathology, but whether pTh17 cells are a Th17 cell subset whose generation is under specific molecular control remains unaddressed. We found that Ras p21 protein activator 3… read more here.
Keywords: pth17; rasa3; cell generation; pathology ... See more keywords
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2018.08.007
Abstract: Summary Mast cells are tissue-resident immune cells. Their overgrowth/overactivation results in a range of common distressing, sometimes life-threatening disorders, including asthma, psoriasis, anaphylaxis, and mastocytosis. Currently, drug discovery is hampered by use of cancer-derived mast… read more here.
Keywords: mast cells; mast; cell generation; mast cell ... See more keywords
Metabolic Control of Memory T-Cell Generation and Stemness.
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DOI: 10.1101/cshperspect.a037770
Abstract: The formation of long-lived memory T cells is a critical feature of the adaptive immune response. T cells undergo metabolic reprogramming to establish a functional memory population. While initial studies characterized key metabolic pathways necessary… read more here.
Keywords: memory cell; cell generation; metabolic control; control memory ... See more keywords
Role of Cytokines in Thymic Regulatory T Cell Generation: Overview and Updates
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.883560
Abstract: CD4+CD25+Foxp3+ Regulatory (Treg) T cells are mainly generated within the thymus. However, the mechanism of thymic Treg cell (tTreg cell) generation remains to be fully revealed. Although the functions of TCR/CD28 co-stimulation have been widely… read more here.
Keywords: cell generation; generation; role cytokines; ttreg cell ... See more keywords