Single-Cell Sequencing in Precision Medicine.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer treatment and research"
DOI: 10.1007/978-3-030-16391-4_9
Abstract: The application of next-generation sequencing in cancer genomics allowed for a better understanding of the genetics and pathogenesis of cancer. Single-cell genomics is a relatively new field that has enhanced our current knowledge of the… read more here.
Keywords: single cell; medicine; cell sequencing; cancer ... See more keywords
Single-Cell Genomics: Approaches and Utility in Immunology.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in immunology"
DOI: 10.1016/j.it.2016.12.001
Abstract: Single-cell genomics offers powerful tools for studying immune cells, which make it possible to observe rare and intermediate cell states that cannot be resolved at the population level. Advances in computer science and single-cell sequencing… read more here.
Keywords: single cell; immunology single; genomics approaches; cell ... See more keywords
Single-Cell Genomics-Based Molecular Algorithm for Early Cancer Detection.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c04968
Abstract: As one of the prime applications of liquid biopsy, the detection of tumor-derived whole cells and molecular markers is enabled in a noninvasive means before symptoms or hints from imaging procedures used for cancer screening.… read more here.
Keywords: cell; detection; single cell; cell genomics ... See more keywords
Single cell genomics yields a wide diversity of small planktonic protists across major ocean ecosystems
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42487-1
Abstract: Marine planktonic protists are critical components of ocean ecosystems and are highly diverse. Molecular sequencing methods are being used to describe this diversity and reveal new associations and metabolisms that are important to how these… read more here.
Keywords: single cell; ocean; planktonic protists; diversity ... See more keywords
Modular barcode beads for microfluidic single cell genomics
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-90255-x
Abstract: Barcode beads allow efficient nucleic acid tagging in single cell genomics. Current barcode designs, however, are fabricated with a particular application in mind. Repurposing to novel targets, or altering to add additional targets as information… read more here.
Keywords: single cell; barcode; barcode beads; cell genomics ... See more keywords
Studying X chromosome inactivation in the single-cell genomic era.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Society transactions"
DOI: 10.1042/bst20170346
Abstract: Single-cell genomics is set to revolutionise our understanding of how epigenetic silencing works; by studying specific epigenetic marks or chromatin conformations in single cells, it is possible to ask whether they cause transcriptional silencing or… read more here.
Keywords: single cell; studying chromosome; chromosome inactivation; cell ... See more keywords
scAB detects multiresolution cell states with clinical significance by integrating single-cell genomics and bulk sequencing data
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1109
Abstract: Abstract Although single-cell sequencing has provided a powerful tool to deconvolute cellular heterogeneity of diseases like cancer, extrapolating clinical significance or identifying clinically-relevant cells remains challenging. Here, we propose a novel computational method scAB, which… read more here.
Keywords: cell; clinical significance; scab; single cell ... See more keywords
Tagmentation-based single-cell genomics.
Sign Up to like & getrecommendations! Published in 2021 at "Genome research"
DOI: 10.1101/gr.275223.121
Abstract: It has been just over 10 years since the initial description of transposase-based methods to prepare high-throughput sequencing libraries, or "tagmentation," in which a hyperactive transposase is used to simultaneously fragment target DNA and append… read more here.
Keywords: single cell; tagmentation; cell genomics; based single ... See more keywords
How Single-Cell Genomics Is Changing Evolutionary and Developmental Biology.
Sign Up to like & getrecommendations! Published in 2017 at "Annual review of cell and developmental biology"
DOI: 10.1146/annurev-cellbio-100616-060818
Abstract: The recent flood of single-cell data not only boosts our knowledge of cells and cell types, but also provides new insight into development and evolution from a cellular perspective. For example, assaying the genomes of… read more here.
Keywords: single cell; biology single; developmental biology; biology ... See more keywords
Single cell genomics in AML: extending the frontiers of AML research.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021014670
Abstract: The era of genomic medicine has allowed AML researchers to improve disease characterization, optimize risk stratification systems, and develop new treatments. While there has been significant progress, AML remains a lethal cancer due to its… read more here.
Keywords: cell; genomics aml; single cell; cell genomics ... See more keywords
Barcode identification for single cell genomics
Sign Up to like & getrecommendations! Published in 2019 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-2612-0
Abstract: BackgroundSingle-cell sequencing experiments use short DNA barcode ‘tags’ to identify reads that originate from the same cell. In order to recover single-cell information from such experiments, reads must be grouped based on their barcode tag,… read more here.
Keywords: single cell; identification single; barcode identification; cell ... See more keywords