α-cell glucokinase suppresses glucose-regulated glucagon secretion
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03034-0
Abstract: Glucagon secretion by pancreatic α-cells is triggered by hypoglycemia and suppressed by high glucose levels; impaired suppression of glucagon secretion is a hallmark of both type 1 and type 2 diabetes. Here, we show that… read more here.
Keywords: glucokinase suppresses; glucagon secretion; glucagon; cell glucokinase ... See more keywords
β‐Cell glucokinase expression was increased in type 2 diabetes subjects with better glycemic control
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Diabetes"
DOI: 10.1111/1753-0407.13380
Abstract: Type 2 diabetes (T2D) is characterized by a progressive deterioration of β‐cell function with a continuous decline in insulin secretion. Glucokinase (GCK) facilitates the rate‐limiting step of glycolysis in pancreatic β‐cells, to acquire the proper… read more here.
Keywords: expression increased; type diabetes; type; glucokinase expression ... See more keywords