Environmental peer pressure: CD4+ T cell help in tolerance and transplantation
Sign Up to like & getrecommendations! Published in 2018 at "Liver Transplantation"
DOI: 10.1002/lt.24873
Abstract: The liver participates in a multitude of metabolic functions that are critical for sustaining human life. Despite constant encounters with antigenic‐rich intestinal blood, oxidative stress, and metabolic intermediates, there is no appreciable immune response. Interestingly,… read more here.
Keywords: cell help; cd4 cell; transplantation; cd4 ... See more keywords
CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109696
Abstract: SUMMARY CD4 T cells are essential for immunity to tuberculosis because they produce cytokines, including interferon-γ. Whether CD4 T cells act as “helper” cells to promote optimal CD8 T cell responses during Mycobacterium tuberculosis is… read more here.
Keywords: cd8 cell; cell help; tuberculosis; cd4 cell ... See more keywords
Transiently antigen-primed B cells return to naive-like state in absence of T-cell help
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15072
Abstract: The perspective that naive B-cell recognition of antigen in the absence of T-cell help causes cell death or anergy is supported by in vivo studies of B cells that are continuously exposed to self-antigens. However,… read more here.
Keywords: cell help; cell; transiently antigen; absence cell ... See more keywords
T cell help in the autoreactive germinal center
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.13192
Abstract: The germinal center serves as a site of B cell selection and affinity maturation, critical processes for productive adaptive immunity. In autoimmune disease tolerance is broken in the germinal center reaction, leading to production of… read more here.
Keywords: follicular cells; autoreactive germinal; center; cell help ... See more keywords