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   Articles with "cell help" as a keyword



Distinct Requirements for CD4+ T Cell Help for Immune Responses Induced by mRNA and Adenovirus‐Vector SARS‐CoV‐2 Vaccines

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recommendations! Published in 2024 at "European Journal of Immunology"

DOI: 10.1002/eji.202451142

Abstract: CD4+ T cells have been established as central orchestrators of cellular and humoral immune responses to infection or vaccination. However, the need for CD4+ T cell help to generate primary CD8+ T cell responses is… read more here.

Keywords: cd4 cell; cell; cell help; vaccine ... See more keywords

Environmental peer pressure: CD4+ T cell help in tolerance and transplantation

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recommendations! Published in 2018 at "Liver Transplantation"

DOI: 10.1002/lt.24873

Abstract: The liver participates in a multitude of metabolic functions that are critical for sustaining human life. Despite constant encounters with antigenic‐rich intestinal blood, oxidative stress, and metabolic intermediates, there is no appreciable immune response. Interestingly,… read more here.

Keywords: cell help; cd4 cell; transplantation; cd4 ... See more keywords
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CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.109696

Abstract: SUMMARY CD4 T cells are essential for immunity to tuberculosis because they produce cytokines, including interferon-γ. Whether CD4 T cells act as “helper” cells to promote optimal CD8 T cell responses during Mycobacterium tuberculosis is… read more here.

Keywords: cd8 cell; cell help; tuberculosis; cd4 cell ... See more keywords

Transiently antigen-primed B cells return to naive-like state in absence of T-cell help

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/ncomms15072

Abstract: The perspective that naive B-cell recognition of antigen in the absence of T-cell help causes cell death or anergy is supported by in vivo studies of B cells that are continuously exposed to self-antigens. However,… read more here.

Keywords: cell help; cell; transiently antigen; absence cell ... See more keywords

T-cell help in the germinal center: homing in on the role of IL-21

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recommendations! Published in 2024 at "International Immunology"

DOI: 10.1093/intimm/dxad056

Abstract: Abstract Interleukin 21 (IL-21) is a pleiotropic cytokine that is overproduced in multiple autoimmune settings. Provision of IL-21 from follicular helper T cells is an important component of T-cell help within germinal centers (GC), and… read more here.

Keywords: role; cell; help germinal; germinal center ... See more keywords

T cell help in the autoreactive germinal center

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recommendations! Published in 2022 at "Scandinavian Journal of Immunology"

DOI: 10.1111/sji.13192

Abstract: The germinal center serves as a site of B cell selection and affinity maturation, critical processes for productive adaptive immunity. In autoimmune disease tolerance is broken in the germinal center reaction, leading to production of… read more here.

Keywords: follicular cells; autoreactive germinal; center; cell help ... See more keywords

Abstract 889: T cell help enhances anti-CD38-mediated NK cell ADCC of multiple myeloma despite expression of CD38 by NK cells

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-889

Abstract: Anti-CD38 monoclonal antibodies such as daratumumab and isatuximab are effective therapeutic agents for some patients with multiple myeloma (MM) even though CD38 is expressed by B cells, monocytes and a significant subset of NK cells… read more here.

Keywords: cd38; cell; cd38 cells; anti cd38 ... See more keywords

Failed Downregulation of PI3K Signaling Makes Autoreactive B Cells Receptive to Bystander T Cell Help.

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recommendations! Published in 2024 at "Journal of immunology"

DOI: 10.4049/jimmunol.2300108

Abstract: The role of T cell help in autoantibody responses is not well understood. Because tolerance mechanisms govern both T and B cell responses, one might predict that both T cell tolerance and B cell tolerance… read more here.

Keywords: cell; autoantibody responses; autoreactive cells; cell help ... See more keywords