The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Current Diabetes Reports"
DOI: 10.1007/s11892-018-1085-2
Abstract: Purpose of ReviewTo discuss advances in our understanding of beta-cell heterogeneity and the ramifications of this for type 1 diabetes (T1D) and its therapy.Recent FindingsA number of studies have challenged the long-standing dogma that the… read more here.
Keywords: beta; type diabetes; beta cell; cell ... See more keywords
Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity.
Sign Up to like & getrecommendations! Published in 2022 at "Cell metabolism"
DOI: 10.1016/j.cmet.2022.03.012
Abstract: Single-cell RNA sequencing (scRNA-seq) has revealed that adult white adipose tissue (WAT) harbors functionally diverse subpopulations of mesenchymal stromal cells that differentially impact tissue plasticity. To date, the molecular basis of this cellular heterogeneity has… read more here.
Keywords: cell heterogeneity; adipose progenitor; cell; heterogeneity ... See more keywords
Recent advances in predictive microbiology: theory and application of conversion from population dynamics to individual cell heterogeneity during inactivation process
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in food science"
DOI: 10.1016/j.cofs.2020.12.019
Abstract: Stochastic approaches for describing microbial growth and/or death responses in foods have gained increased attention in the field of predictive microbiology and quantitative microbial risk assessment. Particularly, recent studies have focused on describing variability and… read more here.
Keywords: microbiology; cell heterogeneity; process; individual cell ... See more keywords
Quantifying Cell Heterogeneity and Subpopulations Using Single Cell Metabolomics.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c05245
Abstract: Mass spectrometry (MS) has become an indispensable tool for metabolomics studies. However, due to the lack of applicable experimental platforms, suitable algorithm, software, and quantitative analyses of cell heterogeneity and subpopulations, investigating global metabolomics profiling… read more here.
Keywords: cell; heterogeneity; heterogeneity subpopulations; quantifying cell ... See more keywords
The physiological role of β-cell heterogeneity in pancreatic islet function
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-021-00568-0
Abstract: Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of transcriptional profile, protein expression and the regulation of hormone release. Even though this heterogeneity has long been appreciated, only within the past… read more here.
Keywords: functional subpopulations; islet; cell; cell heterogeneity ... See more keywords
Volumetric compression develops noise-driven single-cell heterogeneity.
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2110550118
Abstract: Recent studies have revealed that extensive heterogeneity of biological systems arises through various routes ranging from intracellular chromosome segregation to spatiotemporally varying biochemical stimulations. However, the contribution of physical microenvironments to single-cell heterogeneity remains largely… read more here.
Keywords: cell heterogeneity; cell; single cell; volumetric compression ... See more keywords
Single-Cell Heterogeneity of the Liver-Infiltrating Lymphocytes in Individuals with Chronic Echinococcus multilocularis Infection
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00177-22
Abstract: Human alveolar echinococcosis (AE) is a tumor-like disease predominantly located in the liver. The cellular composition and heterogeneity of the lesion-infiltrating lymphocytes which produce an “immunosuppressive” microenvironment are poorly understood. ABSTRACT Human alveolar echinococcosis (AE)… read more here.
Keywords: cell; infiltrating lymphocytes; single cell; heterogeneity liver ... See more keywords
Cell Heterogeneity Analysis in Single-Cell RNA-seq Data Using Mixture Exponential Graph and Markov Random Field Model
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/9919080
Abstract: Advanced single-cell profiling technologies promote exploration of cell heterogeneity, and clustering of single-cell RNA (scRNA-seq) data enables discovery of coexpression genes and network relationships between genes. In particular, single-cell profiling of circulating tumor cells (CTCs)… read more here.
Keywords: single cell; cell rna; seq data; cell ... See more keywords
Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms.
Sign Up to like & getrecommendations! Published in 2022 at "Arteriosclerosis, thrombosis, and vascular biology"
DOI: 10.1161/atvbaha.121.316237
Abstract: Smooth muscle cells and endothelial cells have a remarkable level of plasticity in vascular pathologies. In thoracic and abdominal aortic aneurysms, smooth muscle cells have been suggested to undergo phenotypic switching and to contribute to… read more here.
Keywords: aortic aneurysms; cell; plasticity; smooth muscle ... See more keywords
Single-cell heterogeneity in Sézary syndrome.
Sign Up to like & getrecommendations! Published in 2018 at "Blood advances"
DOI: 10.1182/bloodadvances.2018022608
Abstract: Sézary syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphoma (CTCL) with a median life expectancy of less than 4 years. Although initial treatment responses are often good, the vast majority of patients… read more here.
Keywords: single cell; zary syndrome; malignant cells; cell ... See more keywords
Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing
Sign Up to like & getrecommendations! Published in 2019 at "Military Medical Research"
DOI: 10.1186/s40779-019-0222-9
Abstract: The lung plays a vital role in maintaining homeostasis, as it is responsible for the exchange of oxygen and carbon dioxide. Pulmonary homeostasis is maintained by a network of tissue-resident cells, including epithelial cells, endothelial… read more here.
Keywords: heterogeneity lung; next generation; generation sequencing; cell heterogeneity ... See more keywords