Cell Identity and Spatial Distribution of PD‐1/PD‐L1 Blockade Responders
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202400702
Abstract: The programmed death 1 (PD‐1)/programmed death ligand 1 (PD‐L1) axis inhibits T cell activity, impairing anti‐tumor immunity. Blocking this axis with therapeutic antibodies is one of the most promising anti‐tumor immunotherapies. It has long been… read more here.
Keywords: blockade; spatial distribution; cell identity; identity spatial ... See more keywords
Restoration of pancreatic beta cell identity and autophagy in KATP-induced diabetes by intermittent fasting
Sign Up to like & getrecommendations! Published in 2025 at "Diabetologia"
DOI: 10.1007/s00125-025-06545-w
Abstract: The loss of pancreatic beta cell mass and identity is a hallmark of diabetes. While factors such as beta cell overwork (insulin hypersecretion) and elevated intracellular calcium have been implicated, beta cell identity loss also… read more here.
Keywords: katp; cell; beta cell; cell identity ... See more keywords
Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.08.017
Abstract: Summary Macrophages are strongly adapted to their tissue of residence. Yet, little is known about the cell-cell interactions that imprint the tissue-specific identities of macrophages in their respective niches. Using conditional depletion of liver Kupffer… read more here.
Keywords: cell identity; endothelial cells; kupffer cell; cell ... See more keywords
"Eyeing" corneal stem cell identity, dynamics, and compartmentalization.
Sign Up to like & getrecommendations! Published in 2021 at "Cell stem cell"
DOI: 10.1016/j.stem.2021.06.001
Abstract: The mammalian cornea is maintained by the lifelong self-replenishing activity of its stem cells. In this issue of Cell Stem Cell, Altshuler et al. (2021) and Farrelly et al. (2021) identify two stem cell populations with diverse… read more here.
Keywords: eyeing corneal; corneal stem; stem cell; cell identity ... See more keywords
Capybara: A computational tool to measure cell identity and fate transitions.
Sign Up to like & getrecommendations! Published in 2022 at "Cell stem cell"
DOI: 10.1016/j.stem.2022.03.001
Abstract: Measuring cell identity in development, disease, and reprogramming is challenging as cell types and states are in continual transition. Here, we present Capybara, a computational tool to classify discrete cell identity and intermediate "hybrid" cell… read more here.
Keywords: cell identity; fate; capybara computational; cell ... See more keywords
A decade of questions about the fluidity of cell identity
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/d41586-020-00479-6
Abstract: A method for directly converting connective-tissue cells into neurons opened up a new branch of research into cell-based therapies and called into question long-held beliefs about how development affects a cell’s identity. An historic breakthrough… read more here.
Keywords: questions fluidity; fluidity cell; cell identity; decade questions ... See more keywords
Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15935-0
Abstract: Compromised β-cell identity is emerging as an important contributor to β-cell failure in diabetes; however, the precise mechanism independent of hyperglycemia is under investigation. We have previously reported that mTORC1/Raptor regulates functional maturation in β-cells.… read more here.
Keywords: cell; cell identity; independent hyperglycemia; identity ... See more keywords
MyoD is a 3D genome structure organizer for muscle cell identity
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27865-6
Abstract: The genome exists as an organized, three-dimensional (3D) dynamic architecture, and each cell type has a unique 3D genome organization that determines its cell identity. An unresolved question is how cell type-specific 3D genome structures… read more here.
Keywords: cell identity; muscle cell; muscle; myod ... See more keywords
Gene expression and cell identity controlled by anaphase-promoting complex
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2034-1
Abstract: Metazoan development requires the robust proliferation of progenitor cells, the identities of which are established by tightly controlled transcriptional networks 1 . As gene expression is globally inhibited during mitosis, the transcriptional programs that define… read more here.
Keywords: cell identity; cell; gene expression;
Transcription-factor-mediated supervision of global genome architecture maintains B cell identity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Immunology"
DOI: 10.1038/s41590-018-0234-8
Abstract: Recent studies have elucidated cell-lineage-specific three-dimensional genome organization; however, how such specific architecture is established or maintained is unclear. We hypothesized that lineage-defining transcription factors maintain cell identity via global control of genome organization. These… read more here.
Keywords: architecture; cell identity; transcription factor; genome ... See more keywords
Cell Identity Codes: Understanding Cell Identity from Gene Expression Profiles using Deep Neural Networks
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-38798-y
Abstract: Understanding cell identity is an important task in many biomedical areas. Expression patterns of specific marker genes have been used to characterize some limited cell types, but exclusive markers are not available for many cell… read more here.
Keywords: understanding cell; cell types; cell identity; expression ... See more keywords