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   Articles with "cell immunoglobulin" as a keyword



T‐cell immunoglobulin mucin 3 blockade drives an antitumor immune response in head and neck cancer

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recommendations! Published in 2017 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12029

Abstract: T‐cell immunoglobulin mucin 3 (TIM3) contributes to immune suppression during progression of many cancers, but the precise role of TIM3 in head and neck squamous cell carcinoma (HNSCC) is not clearly understood. In this study,… read more here.

Keywords: immunoglobulin mucin; tim3; expression; cell immunoglobulin ... See more keywords

Killer cell immunoglobulin-like receptor genotypes in a Chilean population from Talca.

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recommendations! Published in 2018 at "Human immunology"

DOI: 10.1016/j.humimm.2018.06.007

Abstract: Ninety healthy and unrelated volunteers were randomly selected to study the gene frequencies of Killer-cell immunoglobulin-like receptors (KIRs) in a Chilean (Talca) population. KIR typing was resolved by PCR-single specific primer (SSP), and their gene… read more here.

Keywords: population; cell immunoglobulin; killer cell; immunoglobulin like ... See more keywords
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Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3).

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recommendations! Published in 2021 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.1c01336

Abstract: T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3; HAVCR2) has emerged as an attractive immune checkpoint target for cancer immunotherapy. TIM-3 is a negative regulator of the systemic immune response to cancer and is expressed… read more here.

Keywords: domain containing; molecule; immunoglobulin mucin; tim ... See more keywords

Genotype B of Killer Cell Immunoglobulin-Like Receptor is Related with Gastric Cancer Lesions

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-24464-2

Abstract: NK cells are important in innate immunity for their capacity to kill infected or cancer cells. The killer cell immunoglobulin-like receptors (KIR) are a family of polymorphic genes with inhibitory and activating functions. The main… read more here.

Keywords: killer cell; gastric cancer; cancer; cell immunoglobulin ... See more keywords
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Distribution of killer cell immunoglobulin-like receptor (KIR) genes in a large, multi-centre cohort of Chinese donors

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recommendations! Published in 2021 at "Annals of Human Biology"

DOI: 10.1080/03014460.2021.1913223

Abstract: Abstract Background The killer cell immunoglobulin-like receptor (KIR), which mediates the killing function of NK cells, is an attractive candidate for adoptive cellular therapy. The ethnic distribution for China provides a unique opportunity to investigate… read more here.

Keywords: kir; kir genes; killer cell; cell immunoglobulin ... See more keywords

Successful Retransplantation With Killer Cell Immunoglobulin-like Receptor Ligand-mismatched Cord Blood in Infant Acute Lymphoblastic Leukemia That Relapsed After Transplantation.

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recommendations! Published in 2023 at "Journal of pediatric hematology/oncology"

DOI: 10.1097/mph.0000000000002614

Abstract: The prognosis of children with KMT2A-rearranged (KMT2A-r) acute lymphoblastic leukemia (ALL) remains dismal. This report describes the successful retransplantation of a patient with infant ALL who relapsed both bone marrow and central nervous system. The… read more here.

Keywords: receptor ligand; like receptor; ligand mismatched; killer cell ... See more keywords

Association between killer cell immunoglobulin‐like receptor 2DS5 gene with essential hypertension in the Chinese Han patients

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recommendations! Published in 2017 at "International Journal of Immunogenetics"

DOI: 10.1111/iji.12342

Abstract: Hypertension has been suggested to be mediated by immunity and inflammation. As immune system genes, killer cell immunoglobulin‐like receptors (KIRs) genes play an important role in the pathogenesis of autoimmune diseases. We conducted a community… read more here.

Keywords: killer cell; immunoglobulin like; hypertension; gene ... See more keywords

Killer cell immunoglobulin‐like receptor three domains long cytoplasmic tail 1 gene *007 may modulate disease progression of human immunodeficiency virus‐1 infection in the Japanese population

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recommendations! Published in 2023 at "International Journal of Immunogenetics"

DOI: 10.1111/iji.12617

Abstract: One of the KIR allele, KIR3DL1*007, was associated with the progression to acquired immunodeficiency syndrome and not with the susceptibility to HIV‐1 infection in the Japanese and Indian populations, implying that KIR3DL1*007‐positive NK cells might… read more here.

Keywords: progression; killer cell; cell immunoglobulin; infection japanese ... See more keywords
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T cell immunoglobulin and mucin domain protein 3 inhibits glycolysis in RAW 264.7 macrophages through Hexokinase 2

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recommendations! Published in 2020 at "Scandinavian Journal of Immunology"

DOI: 10.1111/sji.12981

Abstract: T cell immunoglobulin and mucin domain‐3 (Tim‐3), an immune checkpoint molecule, plays critical roles in maintaining innate immune homeostasis; however, the mechanisms underlying these roles remain to be determined. Here, we determined that Tim‐3 controls… read more here.

Keywords: glycolysis; immunoglobulin mucin; cell immunoglobulin; tim ... See more keywords

Analysis of Killer Cell Immunoglobulin-Like Receptor Genes and Their HLA Ligands in Inflammatory Bowel Diseases

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recommendations! Published in 2020 at "Journal of Immunology Research"

DOI: 10.1155/2020/4873648

Abstract: Genetic studies have illustrated that killer cell immunoglobulin-like receptor (KIR) genes could participate in various autoimmune disorders. We aimed to clarify the role of KIR genes, HLA ligands, HLA-KIR interactions, and their genotypes in inflammatory… read more here.

Keywords: kir; killer cell; immunoglobulin like; like receptor ... See more keywords

Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1

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recommendations! Published in 2018 at "Journal of Clinical Investigation"

DOI: 10.1172/jci98463

Abstract: HLA-B*57 control of HIV involves enhanced CD8+ T cell responses against infected cells, but extensive heterogeneity exists in the level of HIV control among B*57+ individuals. Using whole-genome sequencing of untreated B*57+ HIV-1–infected controllers and… read more here.

Keywords: protection; killer cell; hiv; cell immunoglobulin ... See more keywords