Caspase-1 from Human Myeloid-Derived Suppressor Cells Can Promote T Cell–Independent Tumor Proliferation
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-17-0543
Abstract: MDSCs from HNSCC patients exhibited upregulated caspase-1, a member of the inflammasome complex, and directly promoted tumor cell proliferation. Silencing caspase-1 activity in a mouse model reduced tumor growth, suggesting that targeting caspase-1 could have… read more here.
Keywords: caspase; cell independent; proliferation; mdscs ... See more keywords
Protein kinase Cδ is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.72116
Abstract: Antigens (Ags) with multivalent and repetitive structure elicit IgG production in a T-cell-independent manner. However, the mechanisms by which such T-cell-independent type-2 (TI-2) Ags induce IgG responses remain obscure. Here, we report that B-cell receptor… read more here.
Keywords: independent type; commensal bacteria; protein kinase; cell ... See more keywords