3D full-field quantification of cell-induced large deformations in fibrillar biomaterials by combining non-rigid image registration with label-free second harmonic generation.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.05.015
Abstract: To advance our current understanding of cell-matrix mechanics and its importance for biomaterials development, advanced three-dimensional (3D) measurement techniques are necessary. Cell-induced deformations of the surrounding matrix are commonly derived from the displacement of embedded… read more here.
Keywords: fibrillar biomaterials; cell induced; field quantification; full field ... See more keywords
Nppb Neurons Are Sensors of Mast Cell-Induced Itch
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.02.089
Abstract: SUMMARY Itch is an unpleasant skin sensation that can be triggered by exposure to many chemicals, including those released by mast cells. The natriuretic polypep-tide b (Nppb)-expressing class of sensory neurons, when activated, elicits scratching… read more here.
Keywords: itch; cell induced; nppb neurons; induced itch ... See more keywords
Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T Cell-Induced, and Infectious Colitis in Mice.
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology"
DOI: 10.1053/j.gastro.2020.06.049
Abstract: BACKGROUND & AIMS Intestinal epithelial cells (IECs) provide a barrier that separates the mucosal immune system from the luminal microbiota. IECs constitutively express low levels of major histocompatibility complex (MHC) class II proteins, which are… read more here.
Keywords: mhcii; cell induced; iec mice; colitis ... See more keywords
Immunotherapy with IL12 and PD1/CTLA4 inhibition is effective in advanced ovarian cancer and associates with reversal of myeloid cell-induced immunosuppression
Sign Up to like & getrecommendations! Published in 2023 at "Oncoimmunology"
DOI: 10.1080/2162402x.2023.2198185
Abstract: ABSTRACT The tumor microenvironment (TME) in ovarian cancer (OC) is characterized by immune suppression, due to an abundance of suppressive immune cells populations. To effectively enhance the activity of immune checkpoint inhibition (ICI), there is… read more here.
Keywords: cell; il12; cell induced; ovarian cancer ... See more keywords
Heterogeneity and nonaffinity of cell-induced matrix displacements.
Sign Up to like & getrecommendations! Published in 2018 at "Physical Review E"
DOI: 10.1103/physreve.98.052410
Abstract: Cell contractile forces deform and reorganize the surrounding matrix, but the relationship between the forces and the resulting displacements is complicated by the fact that the fibrous structure brings about a complex set of mechanical… read more here.
Keywords: cell induced; heterogeneity; nonaffinity cell; heterogeneity nonaffinity ... See more keywords
JAK inhibitors disrupt T cell-induced proinflammatory macrophage activation
Sign Up to like & getrecommendations! Published in 2023 at "RMD Open"
DOI: 10.1136/rmdopen-2022-002671
Abstract: Objectives Macrophage subsets, activated by T cells, are increasingly recognised to play a central role in rheumatoid arthritis (RA) pathogenesis. Janus kinase (JAK) inhibitors have proven beneficial clinical effects in RA. In this study, we… read more here.
Keywords: jak inhibitors; cell induced; jak; macrophage ... See more keywords