How Tubular Epithelial Cell Injury Contributes to Renal Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8871-2_11
Abstract: The renal tubules are the major component of the kidney and are vulnerable to a variety of injuries including ischemia, proteinuria, toxins, and metabolic disorders. It has long been believed that tubules are the victim… read more here.
Keywords: epithelial cell; cell injury; fibrosis; cell ... See more keywords
Overexpression of Sirtuin2 prevents high glucose-induced vascular endothelial cell injury by regulating the p53 and NF-κB signaling pathways
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Letters"
DOI: 10.1007/s10529-017-2487-y
Abstract: ObjectivesTo investigate the potential role and underlying mechanism of Sirtuin2 (SIRT2) in regulating high glucose (HG)-induced vascular endothelial cell injury by using human umbilical vein endothelial cells (HUVECs).ResultsSIRT2 mRNA and protein expression levels were decreased… read more here.
Keywords: cell injury; endothelial cell; induced vascular; vascular endothelial ... See more keywords
MicroRNA-141 protects PC12 cells against hypoxia/reoxygenation-induced injury via regulating Keap1-Nrf2 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-019-09804-9
Abstract: To understand the role of microRNA-141 (miR-141) in hypoxia/reoxygenation (H/R)-induced PC12 cell injury via modulation of Keap1/Nrf2 signaling pathway. PC12 cells were divided into Control, H/R, H/R + miR-141 mimics, H/R + NC, H/R + miR-141 inhibitor, H/R + siKeap1 and H/R + miR-141 inhibitors+siKeap1… read more here.
Keywords: cell injury; keap1 nrf2; pc12 cells; mir 141 ... See more keywords
LncRNA TTTY15 knockdown alleviates H2O2-stimulated myocardial cell injury by regulating the miR-98-5p/CRP pathway
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03887-4
Abstract: Acute myocardial infarction (AMI) can lead to myocardial injury, and long non-coding RNA (lncRNA) has been found to play an important regulatory role in the process of myocardial injury. However, the role and potential mechanisms… read more here.
Keywords: cell injury; cell; stimulated myocardial; myocardial cell ... See more keywords
LINC00943 acts as miR-338-3p sponge to promote MPP+-induced SK-N-SH cell injury by directly targeting SP1 in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Brain Research"
DOI: 10.1016/j.brainres.2022.147814
Abstract: BACKGROUND Abnormal expression of long non-coding RNA (lncRNA) is associated with the progression of Parkinson's disease (PD). LINC00943 has been proved to play an important role in the development of PD, so its role and… read more here.
Keywords: cell injury; sp1; mpp; mir 338 ... See more keywords
Farrerol alleviates high glucose-induced renal mesangial cell injury through the ROS/Nox4/ERK1/2 pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108921
Abstract: Hyperproliferation and oxidative stress induced by hyperglycemia in mesangial cells plays crucial roles in the pathological process of diabetic nephropathy. Farrerol, isolated from rhododendron leaves, possesses broad anti-oxidative and anti-inflammatory properties towards several diseases, but… read more here.
Keywords: high glucose; cell injury; mesangial cell; glucose induced ... See more keywords
Mechanistic Insights into PFOS-Mediated Sertoli Cell Injury.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2018.07.001
Abstract: Studies have proven that per- and polyfluoroalkyl substances are harmful to humans, most notably perfluorooctanesulfonate (PFOS). PFOS induces rapid disorganization of actin- and microtubule (MT)-based cytoskeletons in primary cultures of rodent and human Sertoli cells,… read more here.
Keywords: cell injury; sertoli cell; pfos; cell ... See more keywords
Cell injury and receptor expression in the epileptic human amygdala
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.12.017
Abstract: Neuropathological findings in the amygdala obtained from patients with mesial temporal lobe epilepsy (MTLE) indicate varying degrees of histopathological alterations, such as neuronal loss and gliosis. The mechanisms underlying cellular damage in the amygdala of… read more here.
Keywords: cell injury; receptor expression; receptor subunits; expression ... See more keywords
Regulation of Na+‐K+‐ATPase effected high glucose‐induced myocardial cell injury through c‐Src dependent NADPH oxidase/ROS pathway
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.05.023
Abstract: &NA; Depressed Na+/K+‐ATPase activity has long been reported to be involved in diabetic‐related cardiomyocyte death and cardiac dysfunction. However, the nature of directly regulating Na+‐K+‐ATPase in diabetic‐related myocardial diseases remains unknown. Hyperglycemia is believed as… read more here.
Keywords: cell injury; atpase; high glucose; cell ... See more keywords
Perfluorooctanesulfonate (PFOS)-induced Sertoli cell injury through a disruption of F-actin and microtubule organization is mediated by Akt1/2
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01016-8
Abstract: PFOS (perfluorooctanesulfonate, or perfluorooctane sulfonic acid) is an anthropogenic fluorosurfactant widely used in consumer products. While its use in Europe, Canada and the U.S. has been banned due to its human toxicity, it continues to… read more here.
Keywords: pfos induced; cell injury; actin; sertoli cell ... See more keywords
Alkaloid Enantiomers from Isatis tinctoria with Neuroprotective Effects against H2O2-Induced SH-SY5Y Cell Injury.
Sign Up to like & getrecommendations! Published in 2019 at "Planta medica"
DOI: 10.1055/a-1023-8940
Abstract: Six pairs of alkaloid enantiomers including 11 new alkaloids (1A: /1B: -5A: /5B, 6A: ) were isolated from the leaves of Isatis tinctoria. Their structures were established by extensive spectroscopic analyses. Enantiomers were separated successfully… read more here.
Keywords: alkaloid enantiomers; isatis tinctoria; cell injury; h2o2 induced ... See more keywords