Tumor Cell‐Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.06.006
Abstract: Summary The biological and functional heterogeneity between tumors—both across and within cancer types—poses a challenge for immunotherapy. To understand the factors underlying tumor immune heterogeneity and immunotherapy sensitivity, we established a library of congenic tumor… read more here.
Keywords: cell intrinsic; cell infiltration; tumor cell; cell ... See more keywords
TARGETING CELL-INTRINSIC METABOLISM FOR ANTI-FIBROGENIC THERAPY.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2021.02.012
Abstract: In recent years, major advances have been made regarding our understanding on the mechanisms underlying fibrosis progression and regression, and on how coordinated dialog between parenchymal and non-parenchymal cells impacts on the fibrogenic process. Recent… read more here.
Keywords: anti fibrogenic; targeting cell; cell intrinsic; intrinsic metabolism ... See more keywords
βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28933-1
Abstract: Defective angiogenesis underlies over 50 malignant, ischemic and inflammatory disorders yet long-term therapeutic applications inevitably fail, thus highlighting the need for greater understanding of the vast crosstalk and compensatory mechanisms. Based on proteomic profiling of… read more here.
Keywords: regulator; stalk cell; spectrin stalk; cell ... See more keywords
FXR mediates T cell-intrinsic responses to reduced feeding during infection
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2020619117
Abstract: Significance Anorexia or decreased appetite is a common feature of infection. The effects of acute nutritional stress on effector T cells, which are required for pathogen-specific responses and protective immunological memory, are not fully understood.… read more here.
Keywords: fxr; effector cells; infection; cell intrinsic ... See more keywords
LncRNAs as tumor cell intrinsic factors that affect cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "RNA Biology"
DOI: 10.1080/15476286.2020.1767455
Abstract: ABSTRACT Long noncoding RNAs (lncRNAs) have been found to associate with all major types of malignancies and play important roles in regulating several hallmarks of cancer by interacting with proteins, DNA, and RNA. The possible… read more here.
Keywords: lncrnas tumor; cell intrinsic; tumor cell; cancer immunotherapy ... See more keywords
Multicompartment cell-based modeling of confined migration: regulation by cell intrinsic and extrinsic factors
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-05-0313
Abstract: Though cell and nuclear deformability are expected to influence efficiency of confined migration, their individual and collective influence on migration efficiency remains incompletely understood. In addition to cell intrinsic properties, the relevance of cell extrinsic… read more here.
Keywords: confined migration; cell intrinsic; modeling; migration ... See more keywords
Cell-intrinsic and -extrinsic roles of miRNAs in regulating T cell immunity.
Sign Up to like & getrecommendations! Published in 2021 at "Immunological reviews"
DOI: 10.1111/imr.13029
Abstract: T cells are crucial to generate an effective response against numerous invading microbial pathogens and play a pivotal role in tumor surveillance and elimination. However, unwanted T cell activation can also lead to deleterious immune-mediated… read more here.
Keywords: cell intrinsic; cell immunity; intrinsic extrinsic; mirnas regulating ... See more keywords
T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2021-003065
Abstract: Toll-like receptors (TLRs) are evolutionarily conserved molecules that specifically recognize common microbial patterns, and have a critical role in innate and adaptive immunity. Although TLRs are highly expressed by innate immune cells, particularly antigen-presenting cells,… read more here.
Keywords: cell intrinsic; receptor; cancer; car cells ... See more keywords
T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005151
Abstract: Background Stimulator of interferon genes (STING) is an innate immune sensor of cytoplasmic double-stranded DNA originating from microorganisms and host cells. The activation of cytosolic DNA-STING pathway in tumor microenvironments is usually linked to more… read more here.
Keywords: cell; cell intrinsic; sting signaling; intrinsic sting ... See more keywords
Abstract 5861: Tumor cell-intrinsic factors promoting fibrotic tumor microenvironment in gastric cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5861
Abstract: Background: Gastric cancer (GC) is one of the leading causes of death in the world. Evidence has shown over the past decade that cancer-associated fibroblasts (CAFs) play essential roles in various types of cancers, including… read more here.
Keywords: microenvironment; cell intrinsic; tumor cell; tumor ... See more keywords
Tumor Cell–Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-19-0661
Abstract: USP22, a deubiquitinating enzyme, is a tumor-intrinsic factor that can modulate the immune tumor microenvironment in pancreatic cancer. Loss of USP22 sensitizes therapy-resistant tumors, thus, representing a potential target to boost responses of pancreatic tumors… read more here.
Keywords: cell intrinsic; tumor cell; cancer; tumor ... See more keywords