Bubble Forming Films for Spatial Selective Cell Killing.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202008379
Abstract: Photodynamic and photothermal cell killing at the surface of tissues finds applications in medicine. However, a lack of control over heat dissipation following a treatment with light might damage surrounding tissues. A new strategy to… read more here.
Keywords: forming films; bubble films; cell killing; bubble forming ... See more keywords
In vitro study of enhanced photodynamic cancer cell killing effect by nanometer-thick gold nanosheets
Sign Up to like & getrecommendations! Published in 2020 at "Nano Research"
DOI: 10.1007/s12274-020-2990-7
Abstract: Photodynamic therapy (PDT) by near-infrared (NIR) irradiation is a promising technique for treating various cancers. Here, we reported the development of free-standing wafer-scale Au nanosheets (NSs) that exhibited an impressive PDT effect. The Au NSs… read more here.
Keywords: cell killing; study; effect; pdt ... See more keywords
O25 A novel synthetic ω-3 fatty acid epoxide analogue activates breast cancer cell killing in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.06.090
Abstract: Triple-negative breast cancer (TNBC) has a poor prognosis and new drugs are urgently needed. The CYP-derived ω-3 epoxyeicosapentaenoic acid and its saturated analogues were found to activate apoptosis in MDA-MB-231 TNBC cells [1] , [2]… read more here.
Keywords: vitro vivo; vivo; cell killing; breast cancer ... See more keywords
Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine
Sign Up to like & getrecommendations! Published in 2021 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2020.11.016
Abstract: Combining chemo-therapeutics with immune checkpoint inhibitors facilitates killing cancer cells and activating the immune system through inhibiting immune escape. However, their treatment effects remain limited due to the compromised accumulation of both drugs and inhibitors… read more here.
Keywords: immunogenic cell; cell killing; cancer cells; immunosuppression ... See more keywords
Cationic liposome-mediated delivery of reovirus enhances the tumor cell-killing efficiencies of reovirus in reovirus-resistant tumor cells.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.04.006
Abstract: Reovirus induces tumor cell death efficiently and specifically, and thus is currently undergoing clinical testing as an anticancer agent. In the intracellular trafficking of reovirus, proteolytic disassembly of reovirus capsid-proteins and subsequent penetration of viral… read more here.
Keywords: cell killing; reovirus; tumor cells; tumor cell ... See more keywords
Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00576
Abstract: The valine-citrulline (Val-Cit) dipeptide and p-aminobenzyl (PAB) spacer have been commonly used as a cleavable self-immolating linker in ADC design including in the clinically approved ADC, brentuximab vedotin (Adcetris). When the same linker was used… read more here.
Keywords: potency; cell killing; immolation; killing activity ... See more keywords
Electroporation and cell killing by milli- to nanosecond pulses and avoiding neuromuscular stimulation in cancer ablation
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-04868-x
Abstract: Ablation therapies aim at eradication of tumors with minimal impact on surrounding healthy tissues. Conventional pulsed electric field (PEF) treatments cause pain and muscle contractions far beyond the ablation area. The ongoing quest is to… read more here.
Keywords: pef; electroporation cell; cell killing; ablation ... See more keywords
Photoactivated cell-killing involving a low molecular weight, donor–acceptor diphenylacetylene† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00199a
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c9sc00199a
Abstract: Drug-like, donor–acceptor diphenylacetylenes cause efficient cell death upon photoactivation and hence have potential phototherapeutic applications. read more here.
Keywords: donor; photoactivated cell; cell killing; donor acceptor ... See more keywords
Glutamate blunts cell‐killing effects of neutrophils in tumor microenvironment
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DOI: 10.1111/cas.15355
Abstract: Neutrophils are the first defenders of the innate system for injury and infection. They have gradually been recognized as important participants in tumor initiation and development due to their heterogeneity and plasticity. In the tumor… read more here.
Keywords: killing effects; glutamate; tumor cells; tumor microenvironment ... See more keywords
Abstract 2788: VB6-845d tumor cell killing elicits biologic features of immunogenic cell death
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2788
Abstract: VB6-845d is a Targeted Protein Therapeutic, TPT, that comprises a Fab fragment specific for the Epithelial Cell Adhesion Molecule (EpCAM) genetically fused to deBouganin via a furin protease sensitive linker. DeBouganin (deB) is a de-immunized… read more here.
Keywords: vb6 845d; cell killing; tumor cell; cell death ... See more keywords
Abstract 1822: IFN-γ and TRAIL involvement in androgen signaling-mediated NK cell killing of prostate cancer cells and further enhancement by NKG2A checkpoint inhibition with monalizumab
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1822
Abstract: Although blocking the androgen receptor (AR) pathway is a core treatment strategy in early prostate cancer, most patients progress to metastatic castration-resistant prostate cancer(mCRPC). Immunotherapy with PD-1/PD-L1 inhibition has limited activity in mCRPC. AR signaling… read more here.
Keywords: trail; prostate cancer; checkpoint; cell killing ... See more keywords