Construction of a human cell landscape at single-cell level
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2157-4
Abstract: Single-cell analysis is a valuable tool for dissecting cellular heterogeneity in complex systems 1 . However, a comprehensive single-cell atlas has not been achieved for humans. Here we use single-cell mRNA sequencing to determine the… read more here.
Keywords: single cell; construction human; human cell; cell ... See more keywords
Deep learning using bulk RNA-seq data expands cell landscape identification in tumor microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2043662
Abstract: ABSTRACT The tumor microenvironment (TME) profoundly influences tumor progression and affects immunotherapy responses and resistance. Understanding its heterogeneity is the key for developing immunotherapy. However, the available methods can only partially portray the TME heterogeneity… read more here.
Keywords: rna seq; cell; tumor; cell landscape ... See more keywords
Construction of a cross-species cell landscape at single-cell level
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac633
Abstract: Abstract Individual cells are basic units of life. Despite extensive efforts to characterize the cellular heterogeneity of different organisms, cross-species comparisons of landscape dynamics have not been achieved. Here, we applied single-cell RNA sequencing (scRNA-seq)… read more here.
Keywords: species cell; cross species; cell landscape;
Abstract A026: Single-cell landscape deciphering cancer Single-cell landscape deciphering cancer cell-of-origin and cellular heterogeneity in malignant transformation of 13 major tissues
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1538-8514.synthleth24-a026
Abstract: Deciphering disease progression and the sophisticated tumor ecosystems is imperative for exploring tumorigenesis mechanisms and developing novel prevention strategies. Here, we dissected heterogeneous tissue microenvironments during malignant transitions by leveraging data from 4,972,145 single cells… read more here.
Keywords: deciphering cancer; cancer; single cell; landscape deciphering ... See more keywords
Single-cell landscape of mouse lungs exposed to intermittent hypoxia
Sign Up to like & getrecommendations! Published in 2025 at "Respiratory Research"
DOI: 10.1186/s12931-025-03370-y
Abstract: Obstructive sleep apnea–hypopnea syndrome (OSAHS) is a prevalent respiratory disorder characterized by intermittent hypoxia (IH), which promotes pulmonary complications. However, the cellular and molecular mechanisms underlying IH-induced lung remodeling remain poorly understood. We performed comprehensive… read more here.
Keywords: single cell; hypoxia; cell; cell landscape ... See more keywords
Age- and Microbiota-Dependent Cell Stemness Plasticity Revealed by Cattle Cell Landscape
Sign Up to like & getrecommendations! Published in 2023 at "Research"
DOI: 10.34133/research.0025
Abstract: Newborn ruminants are considered functionally monogastric animals. The poor understanding of cellular differences between newborn and mature ruminants prevents the improvement of health and performance of domestic ruminants. Here, we performed the single-cell RNA sequencing… read more here.
Keywords: cell; age microbiota; microbiota dependent; plasticity ... See more keywords