Carcinocythemia—Cancer cell leukemia
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DOI: 10.1002/ajh.25902
Abstract: A 60-year-old man presented with a one-week history of fatigue and bilateral lower extremity pain. Physical examination was normal. Work up revealed anemia (hemoglobin 8.4 g/dL), WBC 4.2 K/uL, platelets 55 K/uL, MCV 83 fL… read more here.
Keywords: cancer; cell leukemia; carcinocythemia cancer; atypical cells ... See more keywords
New treatment options in hairy cell leukemia with focus on BRAF inhibitors
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DOI: 10.1002/hon.2594
Abstract: Hairy cell leukemia (HCL) responds initially very well to chemotherapy with purine analogues. However, up to 50% of patients relapse, often multiple times, and become progressively less sensitive to these myelotoxic and immune‐suppressive drugs. At… read more here.
Keywords: treatment; cell leukemia; hairy cell; braf ... See more keywords
Purine nucleoside analogs plus rituximab are an effective treatment choice for hairy cell leukemia-variant
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DOI: 10.1007/s00277-022-04795-x
Abstract: Both characteristics and optimal treatment strategy for hairy cell leukemia-variant (HCL-v) remain elusive due to its rarity. We retrospectively analyzed the clinical features of HCL-v and the efficacy of first-line treatment options in a large… read more here.
Keywords: leukemia variant; purine nucleoside; treatment; cell leukemia ... See more keywords
Long-term outcomes of elderly hairy cell leukemia patients treated with cladribine
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DOI: 10.1007/s00277-022-04800-3
Abstract: Hairy cell leukemia (HCL) is a rare hematologic disorder characterized by pancytopenia and splenomegaly for which a single course of cladribine is highly effective in inducing complete remissions. However, there is limited real-world data on… read more here.
Keywords: cladribine; hairy cell; treated cladribine; cell leukemia ... See more keywords
Hairy Cell Leukemia (HCL) and HCL Variant: Updates and Spotlights on Therapeutic Advances
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DOI: 10.1007/s11912-022-01285-1
Abstract: This article aims to bring an update on the recent discoveries in hairy cell leukemia (HCL), especially findings in pathophysiology and therapeutic advances. Major discoveries have been made in genetics and epigenetics of HCL. Moreover,… read more here.
Keywords: therapeutic advances; cell leukemia; hairy cell; hcl ... See more keywords
Association of high levels of plasma OX40 with acute adult T-cell leukemia
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DOI: 10.1007/s12185-018-02580-z
Abstract: OX40, a member of the tumor necrosis factor receptor (TNFR) superfamily, co-stimulates activated T cells following interaction with its own ligand OX40L. Human T-cell leukemia virus type-1 (HTLV-1) is an etiological agent of adult T-cell… read more here.
Keywords: acute atl; cell leukemia; adult cell; atl patients ... See more keywords
A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo
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DOI: 10.1007/s12185-020-02935-5
Abstract: Approximately 10–20 million of Human T-cell leukemia virus type-1 (HTLV-1)-infected carriers have been previously reported, and approximately 5% of these carriers develop adult T-cell leukemia/lymphoma (ATL) with a characteristic poor prognosis. In Japan, Southern blotting… read more here.
Keywords: cell leukemia; clonality; method; infected cells ... See more keywords
Myelopathy due to human T-cell leukemia virus type-1 from the donor after ABO-incompatible liver transplantation.
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DOI: 10.1016/j.aohep.2018.06.002
Abstract: We report the case of a 53-year-old-man who developed human T-cell leukemia virus type-1-associated myelopathy (HAM) after ABO-incompatible liver transplantation for alcoholic liver cirrhosis. The living donor was seropositive for human T-cell leukemia virus type-1… read more here.
Keywords: leukemia virus; virus type; cell leukemia; transplantation ... See more keywords
Activation of Notch1 signaling by HTLV-1 Tax promotes proliferation of adult T-cell leukemia cells.
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DOI: 10.1016/j.bbrc.2019.03.094
Abstract: Human T-cell leukemia virus 1 (HTLV-1), an oncogenic retrovirus, and Notch1 signaling, implicated in tumor formation and progression, are both associated with the development of adult T-cell leukemia (ATL). Here we explored the possibility of… read more here.
Keywords: tax; cell leukemia; notch1 signaling; nicd ... See more keywords
High expression of NAMPT in adult T-cell leukemia/lymphoma and anti-tumor activity of a NAMPT inhibitor.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172738
Abstract: Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature T lymphocytes induced by human T-cell leukemia virus-1 and has a poor outcome. New molecular targets for the prevention and treatment of ATL are needed urgently.… read more here.
Keywords: cell leukemia; atl; expression; cell ... See more keywords
Evaluation of artesunate for the treatment of adult T-cell leukemia/lymphoma.
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DOI: 10.1016/j.ejphar.2020.172953
Abstract: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive disease caused by infection with human T-cell leukemia virus type 1 (HTLV-1). Successful treatment is limited by resistance to chemotherapies. Therefore, there is an urgent need to develop… read more here.
Keywords: treatment; cell leukemia; expression; art ... See more keywords