Functional role of glycosphingolipids in contact inhibition of growth in a human mammary epithelial cell line
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12709
Abstract: We have demonstrated previously the involvement of certain glycosphingolipids (GSLs) in ‘contact inhibition’ (dependent on cell‐to‐cell contact) of cell growth. Here, we examined the roles of specific GSLs in contact inhibition of the human epithelial… read more here.
Keywords: epithelial cell; cell line; inhibition; growth ... See more keywords
Dynamic methylation and expression of alternative promoters for oestrogen receptor alpha in cell line models of fulvestrant resistance
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13713
Abstract: Oestrogen receptor alpha (ER; gene symbol ESR1) is the most important prognostic and treatment‐predictive biomarker in breast cancer. Drugs targeting oestrogen and ER for endocrine therapy of breast cancer include aromatase inhibitors, the selective ER… read more here.
Keywords: methylation; resistance; cell line; oestrogen receptor ... See more keywords
Investigation on Cytotoxicity Against Lung Carcinoma Cell Line at New Metallacyclic Complexes of Titanium(IV) Incorporated With β‐Diketone and 4‐(1,4,5‐Triphenyl‐1H‐Imidazol‐2‐Yl) Benzene‐1,2‐Diol Derivatives
Sign Up to like & getrecommendations! Published in 2025 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.70234
Abstract: A series of eight heteroleptic derivatives of titanium(IV) has been synthesized and characterized systematically employing physico‐chemical methods. Derivatives Ti1 [(C37H32N2O6)Ti], Ti2 [(C38H34N2O6)Ti], Ti3 [(C37H31FN2O6)Ti], Ti4 [(C37H31ClN2O6)Ti], Ti5 [(C37H31BrN2O6)Ti], Ti6 [(C37H31N3O8)Ti], Ti7 [(C38H34N2O7)Ti], and Ti8 [(C38H31F3N2O6)Ti]… read more here.
Keywords: cell line; carcinoma cell; cell; lung carcinoma ... See more keywords
Selective Metal‐Coordinated Nanodrugs Based on Thiazine Moiety for Anticancer Therapeutics: Spectroscopic, Theoretical, and Molecular Docking Studies
Sign Up to like & getrecommendations! Published in 2024 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.7840
Abstract: The current study involved production, comprehensive structural analysis, and physicochemical characterizing of two distinctive complexes namely, Cu(TBH) and Zn(TBH); TBH donor ligand: N′‐(1‐(3,6‐dihydro‐4‐hydroxy‐2,6‐dioxo‐2H‐1,3‐thiazin‐5‐yl)ethylidene)‐2‐hydroxybenzohydrazide) using a wide range of analytical methods, including elemental analysis, UV–Vis, FT‐IR,… read more here.
Keywords: docking studies; anticancer; cell line; geometry ... See more keywords
Facile synthesis of C6‐substituted benz[4,5]imidazo[1,2‐a]quinoxaline derivatives and their anticancer evaluation
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000393
Abstract: Cancer remains a leading cause of death worldwide, resulting in continuous efforts to discover and develop highly efficacious anticancer drugs. High‐throughput screening of heterocyclic compound libraries is one of the promising approaches that provided several… read more here.
Keywords: quinoxaline derivatives; cell; cell line; cancer cell ... See more keywords
Upregulation of BAX and caspase‐3, as well as downregulation of Bcl‐2 during treatment with indeno[1,2‐b]quinoxalin derivatives, mediated apoptosis in human cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100454
Abstract: Cancer is the world's foremost cause of death. There are over 100 different forms of cancer. Cancers are frequently named after the organs or tissues in which they develop. As a part of our aim… read more here.
Keywords: cell; cell line; human cancer; downregulation bcl ... See more keywords
2‐Propyl‐3‐Aminoquinazoline‐4(3H)‐one Derivatives as Potential Androgen Receptor Inhibitors: Synthesis and Cytotoxicity Against PC3 Cell Line via In Vitro and In Silico Studies
Sign Up to like & getrecommendations! Published in 2025 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.70048
Abstract: Twenty‐one novel quinazolin‐4(3H)‐one derivatives were synthesized and evaluated for their cytotoxic effects against the PC3 prostate cancer cell line. Structural characterization was performed using FTIR, NMR, and HRMS spectroscopy. Cytotoxicity assays revealed that compound 1… read more here.
Keywords: receptor; androgen receptor; cell line; one derivatives ... See more keywords
Cell line development and bioreactor process optimization for an atezolizumab biosimilar
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2704
Abstract: Checkpoint inhibitors are widely recognized immunotherapeutic drugs, known for their effectiveness in treating various cancers. Atezolizumab, targeting the immune checkpoint programmed death‐ligand 1, is successfully used to treat several types of cancers. Atezolizumab is a… read more here.
Keywords: bioreactor; process; cell line; development ... See more keywords
CRISPR/Cas12a‐mediated CHO genome engineering can be effectively integrated at multiple stages of the cell line generation process for bioproduction
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Journal"
DOI: 10.1002/biot.202000308
Abstract: Most biopharmaceuticals produced today are generated using Chinese hamster ovary (CHO) cells, therefore significant attention is focused on methods to improve CHO cell productivity and product quality. The discovery of gene‐editing tools, such as CRISPR/Cas9,… read more here.
Keywords: crispr cas12a; cho; cell; cell line ... See more keywords
A study of the THP‐1 cell line as the potential biologics production platform with the emphasis on serum‐free media substitution for economic expediency
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202200154
Abstract: Cell cultures are frequently preferred in the industrial production of high value‐added biopharmaceuticals on a large scale. In the production of biopharmaceuticals, the selection of the appropriate cell line, the cell culture medium, and the… read more here.
Keywords: cell; cell line; thp; serum free ... See more keywords
Development and Characterization of the NISTCHO Reference Cell Line
Sign Up to like & getrecommendations! Published in 2025 at "Biotechnology Journal"
DOI: 10.1002/biot.70012
Abstract: Well‐characterized reference materials enable successful collaborations within the scientific community by establishing common reagents for benchmarking studies and reducing the barriers to sharing materials and information. Here, we report the development of NISTCHO, a recombinant… read more here.
Keywords: cell; cell line; nistcho reference; development ... See more keywords