Cell lineage tracing in the retina: Could material transfer distort conclusions?
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24535
Abstract: Recent studies reported the transfer of fluorescent labels between grafted and host cells after transplantation of photoreceptor precursor cells in the mouse retina. While clearly impacting the interpretation of transplantation studies in the retina, the… read more here.
Keywords: tracing retina; cell lineage; retina could; lineage tracing ... See more keywords
Application of Cell Lineage Tracing Combined with Immunofluorescence in the Study of Dentinogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9012-2_5
Abstract: The cell lineage tracing system has been used predominantly in developmental biology studies. The Cre recombinase allows for the activation of the reporter in a specific cell line and all progeny. In this protocol, we… read more here.
Keywords: cell lineage; lineage tracing; immunofluorescence; biology ... See more keywords
Control of cell fraction and population recovery during tissue regeneration in stem cell lineages.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2018.02.017
Abstract: Multicellular tissues are continually turning over, and homeostasis is maintained through regulated proliferation and differentiation of stem cells and progenitors. Following tissue injury, a dramatic increase in cell proliferation is commonly observed, resulting in rapid… read more here.
Keywords: cell lineage; tissue; stem cell; stem ... See more keywords
Lkb1 maintains Treg cell lineage identity
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15876
Abstract: Regulatory T (Treg) cells are a distinct T-cell lineage characterized by sustained Foxp3 expression and potent suppressor function, but the upstream dominant factors that preserve Treg lineage-specific features are mostly unknown. Here, we show that… read more here.
Keywords: lineage; cell lineage; expression; lkb1 ... See more keywords
Tracing cell-lineage histories
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Genetics"
DOI: 10.1038/s41576-018-0015-0
Abstract: Three new studies in Nature and Nature Biotechnology report methods for dissecting transcriptomic cell phenotypes and lineage history simultaneously by combining single-cell RNA sequencing (scRNA-seq) with CRISPR-based lineage tracing. read more here.
Keywords: lineage; cell lineage; lineage histories; tracing cell ... See more keywords
Tumor progression is independent of tumor-associated macrophages in cell lineage-based mouse models of glioblastoma.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2222084120
Abstract: Macrophage targeting therapies have had limited clinical success in glioblastoma (GBM). Further understanding the GBM immune microenvironment is critical for refining immunotherapeutic approaches. Here, we use genetically engineered mouse models and orthotopic transplantation-based GBM models… read more here.
Keywords: cell lineage; tam depletion; tumor; gbm ... See more keywords
Accurate and efficient cell lineage tree inference from noisy single cell data: the maximum likelihood perfect phylogeny approach
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz676
Abstract: MOTIVATION Cells in an organism share a common evolutionary history, called cell lineage tree. Cell lineage tree can be inferred from single cell genotypes at genomic variation sites. Cell lineage tree inference from noisy single… read more here.
Keywords: single cell; tree inference; cell lineage; cell ... See more keywords
Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac041
Abstract: BACKGROUND Pediatric diffuse midline gliomas (DMGs) are incurable childhood cancers. The imipridone ONC201 has shown early clinical efficacy in a subset of DMGs. However, the anticancer mechanisms of ONC201 and its derivative ONC206 have not… read more here.
Keywords: cell; diffuse midline; cell lineage; midline gliomas ... See more keywords
Meningioma transcription factors link cell lineage with systemic metabolic cues
Sign Up to like & getrecommendations! Published in 2018 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noy057
Abstract: Background Tumor cells recapitulate cell-lineage transcriptional programs that are characteristic of normal tissues from which they arise. It is unclear why such lineage programs are fatefully maintained in tumors and if they contribute to cell… read more here.
Keywords: transcription; cell lineage; meningioma; expression ... See more keywords
Comparing phylogenetic approaches to reconstructing cell lineage from microsatellites with missing data.
Sign Up to like & getrecommendations! Published in 2020 at "IEEE/ACM transactions on computational biology and bioinformatics"
DOI: 10.1109/tcbb.2020.2992813
Abstract: Due to the imperfect fidelity of DNA replication, somatic cells acquire DNA mutations at each division which record their lineage history. Microsatellites, tandem repeats of DNA nucleotide motifs, mutate more frequently than other genomic regions… read more here.
Keywords: cell; lineage; cell lineage; comparing phylogenetic ... See more keywords
LineageD: An Interactive Visual System for Plant Cell Lineage Assignments based on Correctable Machine Learning
Sign Up to like & getrecommendations! Published in 2022 at "Computer Graphics Forum"
DOI: 10.1111/cgf.14533
Abstract: We describe LineageD—a hybrid web‐based system to predict, visualize, and interactively adjust plant embryo cell lineages. Currently, plant biologists explore the development of an embryo and its hierarchical cell lineage manually, based on a 3D… read more here.
Keywords: system; cell; machine learning; cell lineage ... See more keywords