A group of tissue‐specific microRNAs contribute to the silencing of CUX1 in different cell lineages during development
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26852
Abstract: Cut‐like homeobox 1 (CUX1) is a highly conserved homeoprotein that functions as a transcriptional repressor of genes specifying terminal differentiation. We previously showed that liver‐specific microRNA‐122 (miR‐122) regulates the timing of liver development by silencing… read more here.
Keywords: cell lineages; tissue specific; cux1; different cell ... See more keywords
Stability of Control Networks in Autonomous Homeostatic Regulation of Stem Cell Lineages
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Mathematical Biology"
DOI: 10.1007/s11538-017-0283-4
Abstract: Design principles of biological networks have been studied extensively in the context of protein–protein interaction networks, metabolic networks, and regulatory (transcriptional) networks. Here we consider regulation networks that occur on larger scales, namely the cell-to-cell… read more here.
Keywords: cell lineages; one cycle; stem cell; cell ... See more keywords
Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Mathematical Biology"
DOI: 10.1007/s11538-017-0333-y
Abstract: This paper investigates cell proliferation dynamics in small tumor cell aggregates using an individual-based model (IBM). The simulation model is designed to study the morphology of the cell population and of the cell lineages as… read more here.
Keywords: cell lineages; lineages solely; model; tumor cell ... See more keywords
Determining the control networks regulating stem cell lineages in colonic crypts.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2017.06.033
Abstract: The question of stem cell control is at the center of our understanding of tissue functioning, both in healthy and cancerous conditions. It is well accepted that cellular fate decisions (such as divisions, differentiation, apoptosis)… read more here.
Keywords: stem cell; cell lineages; cell; control networks ... See more keywords
Direct Reprogramming of Different Cell Lineages into Pancreatic β-Like Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular reprogramming"
DOI: 10.1089/cell.2022.0048
Abstract: One major goal of regenerative medicine is the production of pancreatic endocrine islets to treat insulin-dependent diabetic patients. Among the different methods developed to achieve this goal, a particularly promising approach is direct lineage reprogramming,… read more here.
Keywords: reprogramming different; different cell; direct reprogramming; like cells ... See more keywords
Abstract 4701: Spatial resolution of tumor and immune cell lineages in the hypoxic microenvironment of pancreatic ductal adenocarcinoma (PDAC)
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4701
Abstract: Understanding how the tumor microenvironment (TME) evolves during tumorigenesis and therapeutic response is crucial to developing personalized treatments with the goal of improving cancer therapy. With robust and comprehensive multiplexed imaging technologies, immune biomarker antibodies… read more here.
Keywords: cell lineages; cell; immune cell; pancreatic ductal ... See more keywords
Aging, mortality, and the fast growth trade-off of Schizosaccharomyces pombe
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Biology"
DOI: 10.1371/journal.pbio.2001109
Abstract: Replicative aging has been demonstrated in asymmetrically dividing unicellular organisms, seemingly caused by unequal damage partitioning. Although asymmetric segregation and inheritance of potential aging factors also occur in symmetrically dividing species, it nevertheless remains controversial… read more here.
Keywords: cell lineages; cell; old pole; protein aggregates ... See more keywords
Tracing of Human Tumor Cell Lineages by Mitochondrial Mutations
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.523860
Abstract: Background Previous studies have shown the value in studying lineage tracing in slices of human tumors. However, a tumor is not a two-dimensional structure and to better understand how a tumor, and its corresponding metastasis… read more here.
Keywords: cell lineages; mitochondrial mutations; tracing human; human tumor ... See more keywords
Modulation of Stem Cell Progeny by Probiotics during Regeneration of Gastric Mucosal Erosions
Sign Up to like & getrecommendations! Published in 2021 at "Biology"
DOI: 10.3390/biology10070596
Abstract: Simple Summary The wall of the stomach is easily damaged by different factors leading to serious diseases such as ulcers and cancer. In this study, the effects of a mixture of different types of beneficial… read more here.
Keywords: cell lineages; gastric mucosal; mucosal erosions; stem cell ... See more keywords
HERV-Derived Ervpb1 Is Conserved in Simiiformes, Exhibiting Expression in Hematopoietic Cell Lineages Including Macrophages
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22094504
Abstract: (1) Background: The ERVPb1 gene in humans is derived from an envelope (Env) gene of a human endogenous retrovirus group, HERV-P(b). The ERVPb1 gene reportedly has a conserved open reading frame (ORF) in Old World… read more here.
Keywords: cell lineages; lineages including; hematopoietic cell; expression ... See more keywords
Overgrowth of Squamocolumnar Junction and Dysregulation of Stem Cell Lineages in the Stomach of Vitamin A-Deficient Mice
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14163334
Abstract: Junctional epithelia are common sites for pathological transformations. In mice, the stratified epithelium of the forestomach joins the simple glandular epithelium of the cardia at the limiting ridge. We previously demonstrated the expression of vitamin… read more here.
Keywords: cell; stem cell; overgrowth squamocolumnar; vitamin deficient ... See more keywords