Role of L1CAM in retinoblastoma tumorigenesis: identification of novel therapeutic targets.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13054
Abstract: The study presented focuses on the role of the neuronal cell adhesion molecule L1CAM in retinoblastoma (RB), the most common malignant intraocular childhood tumor. L1CAM is differentially expressed in a variety of human cancers and… read more here.
Keywords: cell lines; l1cam; role; l1cam retinoblastoma ... See more keywords
Prostaglandin A2 induces apoptosis in three cell lines derived from the fall armyworm, Spodoptera frugiperda.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21844
Abstract: Animals maintain homeostasis of cell numbers, constantly creating new cells and eliminating others. Programmed cell death, apoptosis, is a mechanism of cell elimination and it acts in many aspects of animal biology. Drawing on the biomedical… read more here.
Keywords: apoptosis; cell lines; spodoptera frugiperda; biology ... See more keywords
Design, synthesis, biological evaluations, molecular docking, and in vivo studies of novel phthalimide analogs
Sign Up to like & getrecommendations! Published in 2018 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201700363
Abstract: A series of novel phthalimide analogs containing an indole or brominated indole moiety were synthesized and their antimicrobial activity was evaluated. Compound 8 showed a broad spectrum activity, revealing 53–67% of erythromycin activity on the… read more here.
Keywords: design synthesis; novel phthalimide; cell lines; compound ... See more keywords
Synthesis of 5H‐indeno[1,2‐b]pyridine derivatives: Antiproliferative and antimetastatic activities against two human prostate cancer cell lines
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100092
Abstract: This study describes the direct synthesis of 2‐amino‐4‐(phenylsubstituted)‐5H‐indeno[1,2‐b]pyridine‐3‐carbonitrile derivatives 5–21, through sequential multicomponent reaction of aromatic aldehydes, malononitrile, and 1‐indanone in the presence of ammonium acetate and acetic acid (catalytic). The biological study showed that… read more here.
Keywords: pyridine; antimetastatic activities; cell lines; indeno pyridine ... See more keywords
Changes in Chromosome Counts and Patterns in CHO Cell Lines upon Generation of Recombinant Cell Lines and Subcloning.
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology journal"
DOI: 10.1002/biot.201700495
Abstract: Chinese hamster ovary (CHO) cells are the number one production system for therapeutic proteins. A pre-requirement for their use in industrial production of biopharmaceuticals is to be clonal, thus originating from a single cell in… read more here.
Keywords: cell lines; chromosome counts; generation recombinant; recombinant cell ... See more keywords
φC31 -Mediated Cassette Exchange in Sf9 Insect Cells for Stable Expression.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology journal"
DOI: 10.1002/biot.202200557
Abstract: Insect cells, especially Sf9 cells, are commonly used in biomanufacturing due to their advantages in high expression levels and post-translational modification. However, the development of stable expression cell lines via random integration tended to be… read more here.
Keywords: cell; expression; c31; cassette exchange ... See more keywords
Optimizing VLP-production in Gene therapy: Opportunities and challenges for in silico modeling.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology journal"
DOI: 10.1002/biot.202200636
Abstract: Over the past decades, virus-like particle (VLP)-based gene therapy (GT) evolved as a promising approach to cure inherited diseases or cancer. Tremendous costs due to inefficient production processes remain one of the key challenges despite… read more here.
Keywords: vlp production; production; gene therapy; cell lines ... See more keywords
Karyotype variation of CHO host cell lines over time in culture characterized by chromosome counting and chromosome painting
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26453
Abstract: Genomic rearrangements are a common phenomenon in rapidly growing cell lines such as Chinese hamster ovary (CHO) cells, a feature that in the context of production of biologics may lead to cell line and product… read more here.
Keywords: cell lines; time; cho; cell ... See more keywords
Butyrated ManNAc analog improves protein expression in Chinese hamster ovary cells
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26560
Abstract: The chemical additive sodium butyrate (NaBu) has been applied in cell culture media as a direct and convenient method to increase the protein expression in Chinese hamster ovary (CHO) and other mammalian cells. In this… read more here.
Keywords: protein expression; cell lines; treatment; expression ... See more keywords
Apoptosis detection via automated algorithms to analyze biomarker translocation in reporter cells
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DOI: 10.1002/bit.27280
Abstract: Rapid, efficient, and robust quantitative analyses of dynamic apoptotic events are essential in a high‐throughput screening workflow. Currently used methods have several bottlenecks, specifically, limitations in available fluorophores for downstream assays and misinterpretation of statistical… read more here.
Keywords: reporter; cell lines; reporter cells; apoptotic events ... See more keywords
A new nodavirus‐negative Trichoplusia ni cell line for baculovirus‐mediated protein production
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27494
Abstract: Cell lines derived from Trichoplusia ni (Tn) are widely used as hosts in the baculovirus‐insect cell system (BICS). One advantage of Tn cell lines is they can produce recombinant proteins at higher levels than cell… read more here.
Keywords: cell line; cell lines; nodavirus negative; trichoplusia ... See more keywords