Role of L1CAM in retinoblastoma tumorigenesis: identification of novel therapeutic targets.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13054
Abstract: The study presented focuses on the role of the neuronal cell adhesion molecule L1CAM in retinoblastoma (RB), the most common malignant intraocular childhood tumor. L1CAM is differentially expressed in a variety of human cancers and… read more here.
Keywords: cell lines; l1cam; role; l1cam retinoblastoma ... See more keywords
Binuclear Ruthenium (II) Complexes Featuring Arylthiourea Ligands: Synthesis, Crystal Structure and Anticancer Assessment
Sign Up to like & getrecommendations! Published in 2025 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.70146
Abstract: A new set of arene binuclear Ru (II)complexes of the type [RuCl2(η6‐p‐cymene)(η2‐N^S‐aroylthiourea)] has been synthesised to examine the effect on the cytotoxicity against human cancer cell lines. The formation of all the complexes (TC1–TC3) has… read more here.
Keywords: ruthenium; cancer; cell lines; structure ... See more keywords
Prostaglandin A2 induces apoptosis in three cell lines derived from the fall armyworm, Spodoptera frugiperda.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21844
Abstract: Animals maintain homeostasis of cell numbers, constantly creating new cells and eliminating others. Programmed cell death, apoptosis, is a mechanism of cell elimination and it acts in many aspects of animal biology. Drawing on the biomedical… read more here.
Keywords: apoptosis; cell lines; spodoptera frugiperda; biology ... See more keywords
Design, synthesis, biological evaluations, molecular docking, and in vivo studies of novel phthalimide analogs
Sign Up to like & getrecommendations! Published in 2018 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201700363
Abstract: A series of novel phthalimide analogs containing an indole or brominated indole moiety were synthesized and their antimicrobial activity was evaluated. Compound 8 showed a broad spectrum activity, revealing 53–67% of erythromycin activity on the… read more here.
Keywords: design synthesis; novel phthalimide; cell lines; compound ... See more keywords
Synthesis of 5H‐indeno[1,2‐b]pyridine derivatives: Antiproliferative and antimetastatic activities against two human prostate cancer cell lines
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100092
Abstract: This study describes the direct synthesis of 2‐amino‐4‐(phenylsubstituted)‐5H‐indeno[1,2‐b]pyridine‐3‐carbonitrile derivatives 5–21, through sequential multicomponent reaction of aromatic aldehydes, malononitrile, and 1‐indanone in the presence of ammonium acetate and acetic acid (catalytic). The biological study showed that… read more here.
Keywords: pyridine; antimetastatic activities; cell lines; indeno pyridine ... See more keywords
Methyl Gallate: A Potent Bioactive Compound Promoting Osteogenic Differentiation by Regulating Runx2 and Cbfa1 in Osteoblastic Cell Lines.
Sign Up to like & getrecommendations! Published in 2025 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2784
Abstract: Osteoporosis is a widespread condition, particularly affecting women and high‐aged groups, with limited allopathic treatment options leading to adverse effects. The interest in natural remedies for osteoporosis is growing, and plant‐based compounds are being explored… read more here.
Keywords: differentiation; cell lines; methyl gallate; compound ... See more keywords
Changes in Chromosome Counts and Patterns in CHO Cell Lines upon Generation of Recombinant Cell Lines and Subcloning.
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology journal"
DOI: 10.1002/biot.201700495
Abstract: Chinese hamster ovary (CHO) cells are the number one production system for therapeutic proteins. A pre-requirement for their use in industrial production of biopharmaceuticals is to be clonal, thus originating from a single cell in… read more here.
Keywords: cell lines; chromosome counts; generation recombinant; recombinant cell ... See more keywords
φC31 -Mediated Cassette Exchange in Sf9 Insect Cells for Stable Expression.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology journal"
DOI: 10.1002/biot.202200557
Abstract: Insect cells, especially Sf9 cells, are commonly used in biomanufacturing due to their advantages in high expression levels and post-translational modification. However, the development of stable expression cell lines via random integration tended to be… read more here.
Keywords: cell; expression; c31; cassette exchange ... See more keywords
Optimizing VLP-production in Gene therapy: Opportunities and challenges for in silico modeling.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology journal"
DOI: 10.1002/biot.202200636
Abstract: Over the past decades, virus-like particle (VLP)-based gene therapy (GT) evolved as a promising approach to cure inherited diseases or cancer. Tremendous costs due to inefficient production processes remain one of the key challenges despite… read more here.
Keywords: vlp production; production; gene therapy; cell lines ... See more keywords
Duplication of a chromosome 2 segment in production CHO cell lines correlates with age‐related growth improvement
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202300407
Abstract: Monitoring the stability of recombinant Chinese Hamster Ovary (CHO) cell lines is essential to ensure the selection of production cell lines suitable for biomanufacturing. It has been frequently observed that recombinant CHO cell lines develop… read more here.
Keywords: cell lines; duplication; cell; age correlated ... See more keywords
Generation of stable suspension producer cell lines for serum‐free lentivirus production
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202400090
Abstract: The production of lentiviral vectors (LVs) pseudotyped with the vesicular stomatitis virus envelope glycoprotein (VSV‐G) is limited by the associated cytotoxicity of the envelope and by the production methods used, such as transient transfection of… read more here.
Keywords: producer cell; cell lines; stable suspension; cell ... See more keywords