CAR‐T cell therapy targeting B cell maturation antigen is effective for relapsed/refractory multiple myeloma, including cases with poor performance status
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26583
Abstract: In this open‐label, single‐arm, phase I/II clinical trial, we evaluated the efficacy of anti‐B cell maturation antigen (BCMA) chimeric antigen receptor (CAR)‐T cell (HDS269B) therapy in 49 relapsed/refractory multiple myeloma (RRMM) patients, including 20 with… read more here.
Keywords: cell; therapy; car; maturation antigen ... See more keywords
B‐cell maturation antigen‐specific chimeric antigen receptor T cells for multiple myeloma: Clinical experience and future perspectives
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.33002
Abstract: Despite major advances in the treatment of multiple myeloma (MM), it remains a largely incurable disease with long‐term control often dependent on continuous therapy. More effective, better tolerated treatments are therefore required to achieve durable… read more here.
Keywords: maturation antigen; multiple myeloma; antigen; cell maturation ... See more keywords
The Role of B-Cell Maturation Antigen in the Biology and Management of, and as a Potential Therapeutic Target in, Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2017 at "Targeted Oncology"
DOI: 10.1007/s11523-017-0538-x
Abstract: B-cell maturation antigen (BCMA) was originally identified as a cell membrane receptor, expressed exclusively on late stage B-cells and plasma cells (PCs). Investigations of BCMA as a target for therapeutic intervention in multiple myeloma (MM)… read more here.
Keywords: bcma; target; biology; antigen ... See more keywords
Mitf is required for T cell maturation by regulating dendritic cell homing to the thymus.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.01.091
Abstract: Thymic dendritic cells (DCs) promote immune tolerance by regulating negative selection of autoreactive T cells in the thymus. How DC homing to the thymus is transcriptionally regulated is still unclear. Microphthalmia-associated transcription factor (Mitf) is… read more here.
Keywords: homing thymus; cell maturation; mitf required; required cell ... See more keywords
Targeted MIP-3β plasmid nanoparticles induce dendritic cell maturation and inhibit M2 macrophage polarisation to suppress cancer growth.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120046
Abstract: In recent decades, cancer immunotherapy has demonstrated considerable clinical advantages in cancer therapy. Particularly, the use of immunological gene therapy continues to grow in this field. Macrophage Inflammatory Protein 3 Beta (MIP-3β) has emerged as… read more here.
Keywords: mip plasmid; cell maturation; macrophage; cancer ... See more keywords
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.
Sign Up to like & getrecommendations! Published in 2022 at "Cell metabolism"
DOI: 10.1016/j.cmet.2021.12.021
Abstract: In diabetes, glucagon secretion from pancreatic α cells is dysregulated. The underlying mechanisms, and whether dysfunction occurs uniformly among cells, remain unclear. We examined α cells from human donors and mice using electrophysiological, transcriptomic, and… read more here.
Keywords: type diabetes; cell maturation; maturation state; cell ... See more keywords
Synaptotagmins Tweak Functional β Cell Maturation.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.04.018
Abstract: Immature β cells secrete insulin at a lower glucose threshold compared to mature β cells. In this issue of Developmental Cell, Huang et al. (2018) show that the increase in glucose threshold during β cell maturation… read more here.
Keywords: synaptotagmins tweak; cell maturation; tweak functional; cell ... See more keywords
An update on B-cell maturation antigen-targeted therapies in Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2021.1872540
Abstract: ABSTRACT Introduction: B-cell maturation antigen (BCMA) targeted therapy (BCMA-TT) has emerged as a promising treatment for Multiple Myeloma (MM). the three most common treatment modalities for targeting BCMA are antibody-drug conjugates (ADCs), bispecific antibody constructs,… read more here.
Keywords: maturation antigen; antibody; multiple myeloma; antigen ... See more keywords
Multiomics Approach to Profiling Sertoli Cell Maturation during Development of the Spermatogonial Stem Cell Niche.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaad004
Abstract: Spermatogonial stem cells (SSCs) are the basis of spermatogenesis, a complex process supported by a specialized microenvironment, called the SSC niche. Postnatal development of SSCs is characterized by distinct metabolic transitions from prepubertal to adult… read more here.
Keywords: cell; maturation; niche; cell maturation ... See more keywords
Impaired B-Cell Maturation Contributes to Reduced B Cell Numbers and Poor Prognosis in Sepsis.
Sign Up to like & getrecommendations! Published in 2019 at "Shock"
DOI: 10.1097/shk.0000000000001478
Abstract: BACKGROUND Reduced B cell numbers plays a critical role in sepsis immunosuppression. The role of B-cell maturation regulated by T follicular helper (Tfh) cells in reduced B cell numbers during sepsis remains unclear. We tested… read more here.
Keywords: reduced cell; sepsis; cell numbers; cell maturation ... See more keywords
Normalization of serum B‐cell maturation antigen levels predicts overall survival among multiple myeloma patients starting treatment
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.16752
Abstract: Serum B‐cell maturation antigen (sBCMA) is a novel biomarker for B‐cell malignancies. A normal reference range ( read more here.
Keywords: maturation antigen; serum cell; treatment; cell maturation ... See more keywords