How Polycomb‐Mediated Cell Memory Deals With a Changing Environment
Sign Up to like & getrecommendations! Published in 2018 at "BioEssays"
DOI: 10.1002/bies.201700137
Abstract: Cells and tissues are continuously exposed to a changing microenvironment, hence the necessity of a flexible modulation of gene expression that in complex organism have been achieved through specialized chromatin mechanisms. Chromatin‐based cell memory enables… read more here.
Keywords: polycomb mediated; cell memory; mediated cell; cell ... See more keywords
Regulatory T‐cell‐derived interleukin‐15 shapes cytotoxic T cell memory
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202250238
Abstract: It is well known that regulatory T‐cells (Tregs) are required to prevent autoimmunity, but they may also have some less‐well understood immune‐stimulatory effects. In particular, in CD8+ T‐cell responses Tregs select high‐affinity clones upon priming… read more here.
Keywords: cell; regulatory cell; cell memory; memory ... See more keywords
In Vitro Generation of Stem Cell Memory-Like T Cells from Activated T Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0266-9_11
Abstract: Adoptive T-cell therapy is an attractive strategy for cancer immunotherapy. The transfer of in vitro expanded tumor-associated antigen (TAA)-specific T cells from patients may effectively fight against the original tumor cells. The chimeric antigen receptor-engineered… read more here.
Keywords: stem cell; like cells; cell memory; activated cells ... See more keywords
T Cell Memory: Understanding COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.12.009
Abstract: As the SARS-CoV-2 pandemic has progressed, increasing attention has focused on establishing natural and vaccine-induced immunity against this coronavirus and the disease, COVID-19, that it causes. In this Primer, we explain the fundamental features of… read more here.
Keywords: immunity; memory understanding; cell memory; covid ... See more keywords
B cell memory: understanding COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.01.014
Abstract: Immunological memory is a mechanism to protect us against reinfection. Antibodies produced by B cells are integral to this defence strategy and underlie virtually all vaccine success. Here we explain how B cells memory is… read more here.
Keywords: cell memory; memory understanding; memory; understanding covid ... See more keywords
Homeostatic Cytokines Drive Epigenetic Reprogramming of Activated T Cells into a “Naive-Memory” Phenotype
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.100989
Abstract: Summary Primary stimulation of T cells is believed to trigger unidirectional differentiation from naive to effector and memory subsets. Here we demonstrate that IL-7 can drive the phenotypic reversion of recently differentiated human central and… read more here.
Keywords: cell memory; cells naive; differentiation; homeostatic cytokines ... See more keywords
Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22036-z
Abstract: T-cell immunity is important for recovery from COVID-19 and provides heightened immunity for re-infection. However, little is known about the SARS-CoV-2-specific T-cell immunity in virus-exposed individuals. Here we report virus-specific CD4+ and CD8+ T-cell memory… read more here.
Keywords: close contacts; infection; cell memory; sars cov ... See more keywords
OCA-B/Pou2af1 is sufficient to promote CD4+ T cell memory and prospectively identifies memory precursors
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2309153121
Abstract: Significance The molecular mechanisms leading to functional CD4+ T cell memory are incompletely defined and memory progenitors difficult to identify. Here, we show that expression of the Oct coactivator from B cells (OCA-B) transcription coactivator… read more here.
Keywords: cd4 cell; memory; cell memory; sufficient promote ... See more keywords
Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8+ T cells for adoptive immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Oncoimmunology"
DOI: 10.1080/2162402x.2018.1488565
Abstract: ABSTRACT Adoptive T cell therapy has shown clinical potential for patients with cancer, though effective treatment is dependent on longevity and potency of the exploited tumor-reactive T cells. Previously, we showed that ex vivo inhibition… read more here.
Keywords: stem cell; cd8 cells; cd8; cell memory ... See more keywords
Optimal CD8+ T‐cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses
Sign Up to like & getrecommendations! Published in 2021 at "Immunology"
DOI: 10.1111/imm.13368
Abstract: Cytomegalovirus (CMV) induction of large frequencies of highly functional memory T cells has attracted much interest in the utility of CMV‐based vaccine vectors, with exciting preclinical data obtained in models of infectious diseases and cancer.… read more here.
Keywords: memory formation; cell memory; cell; memory ... See more keywords
Fatty acid metabolism in CD8+ T cell memory: Challenging current concepts
Sign Up to like & getrecommendations! Published in 2018 at "Immunological Reviews"
DOI: 10.1111/imr.12655
Abstract: CD8+ T cells are key members of the adaptive immune response against infections and cancer. As we discuss in this review, these cells can present diverse metabolic requirements, which have been intensely studied during the… read more here.
Keywords: cd8 cell; cd8; metabolism; cell memory ... See more keywords